Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder - New York Times: Well (2014)

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Top scans: Healthy control patient; Bottom scans: chronic fatigue syndrome (CFS) patient

Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder - New York Times: Well (2014) is one of many ME/CFS articles by David Tuller.[1]

The images document neuroinflammation which causes many neurological symptoms experienced by patients.

Plainly seen is the result of neuroinflammation's impact on the brain.

Brain imaging studies mentioned in article[edit | edit source]

  • 2014, A Japanese PET study looked at neuroinflammation in 9 patients with ME/CFS and 10 controls. They measured a protein expressed by activated microglia, and found that values in the cingulate cortex, hippocampus, amygdala, thalamus, midbrain, and pons were 45%–199% higher in ME/CFS patients than in healthy controls. The values in the amygdala, thalamus, and midbrain positively correlated with cognitive impairment score, the values in the cingulate cortex and thalamus positively correlated with pain score, and the value in the hippocampus positively correlated with depression score.[5][4]

Myalgic encephalomyelitis[edit | edit source]

Myalgic encephalomyelitis (ME) was the original name for chronic fatigue syndrome (CFS); the names are used interchangeably or with the acronym ME/CFS.[6] The name ME[7] was coined by Dr. Melvin Ramsay following the 1955 Royal Free Hospital outbreak[8] and is a portmanteau of several of the key signs and symptoms of the disease: myalgic (muscle pain), encephalo (brain), myel (spinal cord), itis (inflammation).[9] The central nervous system (brain and spinal cord) are inflamed.[6]

Criterion defining ME, CFS, and ME/CFS[edit | edit source]

Patients that meet the International Consensus Criteria (ICC) defining ME are usually more severely impaired than patients that meet the Canadian Consensus Criteria (CCC) defining ME/CFS, or the minimum core symptoms needed to diagnose patients with Systemic Exertion Intolerance Disease (SEID); also an ME/CFS criterion. Researchers believe all patients meeting these criterion, including Fukuda criteria (with post-exertional malaise "option") defining CFS, are experiencing brain inflammation.[citation needed]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Tuller, David (November 14, 2014). "Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder". The New York Times - Well. Retrieved November 28, 2018. Cite has empty unknown parameter: |dead-url= (help)
  2. Zeineh, Michael M.; Kang, James; Atlas, Scott W.; Raman, Mira M.; Reiss, Allan L.; Norris, Jane L.; Valencia, Ian; Montoya, Jose G. (February 2015). "Right Arcuate Fasciculus Abnormality in Chronic Fatigue Syndrome". Radiology. 274 (2): 517–526. doi:10.1148/radiol.14141079. ISSN 0033-8419.
  3. Goldman, Bruce (October 28, 2014). "Study finds brain abnormalities in chronic fatigue patients". Standford University News Center. Retrieved January 10, 2020. Cite has empty unknown parameter: |dead-url= (help)
  4. 4.0 4.1 Tuller, David (November 24, 2014), "Brains of People With Chronic Fatigue Syndrome Offer Clues About Disorder", NY Times
  5. Nakatomi, Yasuhito; Mizuno, Kei; Ishii, Akira; et al. (March 24, 2014), "Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An ¹¹C-(R)-PK11195 PET Study", Journal of Nuclear Medicine, 2014 Jun, 55(6): 945-50, doi:10.2967/jnumed.113.131045, PMID 24665088
  6. 6.0 6.1 Dellwo, Adrienne (November 24, 2018). "Myalgic Encephalomyelitis or Chronic Fatigue Syndrome". Verywell Health. Retrieved November 28, 2018. Cite has empty unknown parameter: |dead-url= (help)
  7. Dellwo, Adrienne (July 23, 2018). "Myalgic Encephalomyelitis: Chronic Fatigue Syndrome's Other Name". Verywell Health. Retrieved August 12, 2018. Cite has empty unknown parameter: |dead-url= (help)
  8. "An Outbreak of Encephalomyelitis in the Royal Free Hospital Group, London, in 1955". British Medical Journal. 2 (5050): 895–904. October 19, 1957. ISSN 0007-1447. PMID 13472002.
  9. The Terminology of ME & CFS By Professor Malcolm Hooper
  10. "myalgic". TheFreeDictionary.com. Retrieved August 12, 2018.
  11. "encephalo-". TheFreeDictionary.com. Retrieved August 12, 2018.
  12. "myel-". TheFreeDictionary.com. Retrieved August 12, 2018.
  13. "Itis". TheFreeDictionary.com. Retrieved August 12, 2018. Cite has empty unknown parameter: |dead-url= (help)