CD1d: Difference between revisions
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CD1d is a [[glycoprotein]] expressed on some cells containing [[antigen]]s, such as in the case of intracellular infection. They activate [[natural killer cell]]s. | CD1d is a [[glycoprotein]] expressed on some cells containing [[antigen]]s, such as in the case of intracellular infection. They activate [[natural killer cell]]s. | ||
The gamma [[herpesvirus]]es [[Epstein-Barr virus]] and [[Kaposi's sarcoma-associated herpesvirus]] evade [[immune system]] detection and persist in [[B cell]]s by down regulating the expression of CD1d, enabling them to avoid immune recognition by natural killer cells.<ref>{{Cite journal | last = Sanchez| first = David Jesse | last2 = Gumperz| first2=Jenny E. | last3 = Ganem| first3=Don|date=2005-05-02|title=Regulation of CD1d expression and function by a herpesvirus infection | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087176/|journal=Journal of Clinical Investigation|volume=115|issue=5|pages=1369–1378|doi=10.1172/JCI200524041|issn=0021-9738|pmc=1087176|pmid=15864354|quote=|via=}}</ref><ref>{{Cite journal | last = Chung| first = Brian K. | last2 = Tsai| first2=Kevin | last3 = Allan| first3=Lenka L. | last4 = Zheng| first4=Dong Jun | last5 = Nie| first5=Johnny C. | last6 = Biggs| first6=Catherine M. | last7 = Hasan| first7=Mohammad R. | last8 = Kozak| first8=Frederick K. | last9 = van den Elzen| first9=Peter|date=2013-10-10|title=Innate immune control of EBV-infected B cells by invariant natural killer T cells |url =https://www.ncbi.nlm.nih.gov/pubmed/23974196|journal=Blood|volume=122|issue=15|pages=2600–2608|doi=10.1182/blood-2013-01-480665|issn=1528-0020|pmid=23974196}}</ref><ref>{{Cite journal | last = Priatel| first = John J | last2 = Chung| first2=Brian K | last3 = Tsai| first3=Kevin | last4 = Tan| first4=Rusung|date=2014-04-09|title=Natural killer T cell strategies to combat Epstein–Barr virus infection | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063158/|journal=Oncoimmunology|volume=3|doi=10.4161/onci.28329|issn=2162-4011|pmc=4063158|pmid=25050206|issue=|pages=|quote=|via=}}</ref> | The gamma [[herpesvirus]]es [[Epstein-Barr virus]] and [[Kaposi's sarcoma-associated herpesvirus]] evade [[immune system]] detection and persist in [[B cell]]s by down regulating the expression of CD1d, enabling them to avoid immune recognition by natural killer cells.<ref>{{Cite journal | last = Sanchez| first = David Jesse | last2 = Gumperz| first2=Jenny E. | last3 = Ganem| first3=Don|date=2005-05-02|title=Regulation of CD1d expression and function by a herpesvirus infection | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087176/|journal=Journal of Clinical Investigation|volume=115|issue=5|pages=1369–1378|doi=10.1172/JCI200524041|issn=0021-9738|pmc=1087176|pmid=15864354|quote=|via=}}</ref><ref>{{Cite journal | last = Chung| first = Brian K. | last2 = Tsai| first2=Kevin | last3 = Allan| first3=Lenka L. | last4 = Zheng| first4=Dong Jun | last5 = Nie | first5=Johnny C. | last6 = Biggs| first6=Catherine M. | last7 = Hasan| first7=Mohammad R. | last8 = Kozak| first8=Frederick K. | last9 = van den Elzen| first9=Peter|date=2013-10-10|title=Innate immune control of EBV-infected B cells by invariant natural killer T cells |url =https://www.ncbi.nlm.nih.gov/pubmed/23974196|journal=Blood|volume=122|issue=15|pages=2600–2608|doi=10.1182/blood-2013-01-480665|issn=1528-0020|pmid=23974196}}</ref><ref>{{Cite journal | last = Priatel| first = John J | last2 = Chung| first2=Brian K | last3 = Tsai| first3=Kevin | last4 = Tan| first4=Rusung|date=2014-04-09|title=Natural killer T cell strategies to combat Epstein–Barr virus infection | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063158/|journal=Oncoimmunology|volume=3|doi=10.4161/onci.28329|issn=2162-4011|pmc=4063158|pmid=25050206|issue=|pages=|quote=|via=}}</ref> | ||
==Learn more == | ==Learn more == | ||
Revision as of 01:04, October 12, 2022
 | This article is a stub. |
CD1d is a glycoprotein expressed on some cells containing antigens, such as in the case of intracellular infection. They activate natural killer cells.
The gamma herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus evade immune system detection and persist in B cells by down regulating the expression of CD1d, enabling them to avoid immune recognition by natural killer cells.[1][2][3]
Learn more
See also
References
- ↑ Sanchez, David Jesse; Gumperz, Jenny E.; Ganem, Don (May 2, 2005). "Regulation of CD1d expression and function by a herpesvirus infection". Journal of Clinical Investigation. 115 (5): 1369–1378. doi:10.1172/JCI200524041. ISSN 0021-9738. PMC 1087176. PMID 15864354.
- ↑ Chung, Brian K.; Tsai, Kevin; Allan, Lenka L.; Zheng, Dong Jun; Nie, Johnny C.; Biggs, Catherine M.; Hasan, Mohammad R.; Kozak, Frederick K.; van den Elzen, Peter (October 10, 2013). "Innate immune control of EBV-infected B cells by invariant natural killer T cells". Blood. 122 (15): 2600–2608. doi:10.1182/blood-2013-01-480665. ISSN 1528-0020. PMID 23974196.
- ↑ Priatel, John J; Chung, Brian K; Tsai, Kevin; Tan, Rusung (April 9, 2014). "Natural killer T cell strategies to combat Epstein–Barr virus infection". Oncoimmunology. 3. doi:10.4161/onci.28329. ISSN 2162-4011. PMC 4063158. PMID 25050206.
