CD1d: Difference between revisions
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CD1d is a [[glycoprotein]] expressed on some cells containing [[antigen]]s, such as in the case of intracellular infection. They activate [[natural killer cell]]s. | CD1d is a [[glycoprotein]] expressed on some cells containing [[antigen]]s, such as in the case of intracellular infection. They activate [[natural killer cell]]s. | ||
The gamma [[herpesvirus]]es [[Epstein-Barr virus]] and [[Kaposi's sarcoma-associated herpesvirus]] evade [[immune system]] detection and persist in [[B cell]]s by down regulating the expression of CD1d, enabling them to avoid immune recognition by natural killer cells.<ref>{{Cite journal | last = Sanchez | first = David Jesse | last2 = Gumperz | first2 = Jenny E. | last3 = Ganem| first3 = Don | date = 2005-05-02 | title = Regulation of CD1d expression and function by a herpesvirus infection | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087176/|journal=Journal of Clinical Investigation|volume=115|issue=5 | pages = 1369–1378|doi=10.1172/JCI200524041|issn=0021-9738|pmc=1087176|pmid=15864354|quote=|via=}}</ref><ref>{{Cite journal | last = Chung | first = Brian K. | last2 = Tsai | first2 = Kevin | last3 = Allan | first3 = Lenka L. | last4 = Zheng | first4 = Dong Jun | last5 = Nie | first5 = Johnny C. | last6 = Biggs | first6 = Catherine M. | last7 = Hasan | first7 = Mohammad R. | last8 = Kozak | first8 = Frederick K. | last9 = van den Elzen | first9 = Peter | date = 2013-10-10 | title = Innate immune control of EBV-infected B cells by invariant natural killer T cells |url =https://www.ncbi.nlm.nih.gov/pubmed/23974196|journal=Blood|volume=122|issue=15 | pages = 2600–2608|doi=10.1182/blood-2013-01-480665|issn=1528-0020|pmid=23974196}}</ref><ref>{{Cite journal | last = Priatel | first = John J | last2 = Chung | first2 = Brian K | last3 = Tsai | first3 = Kevin | last4 = Tan | first4 = Rusung | date = 2014-04-09 | title = Natural killer T cell strategies to combat Epstein–Barr virus infection | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063158/|journal=Oncoimmunology|volume=3|doi=10.4161/onci.28329|issn=2162-4011|pmc=4063158|pmid=25050206|issue=|pages=|quote=|via=}}</ref> | The gamma [[herpesvirus]]es [[Epstein-Barr virus]] and [[Kaposi's sarcoma-associated herpesvirus]] evade [[immune system]] detection and persist in [[B cell]]s by down regulating the expression of CD1d, enabling them to avoid immune recognition by natural killer cells.<ref>{{Cite journal | last = Sanchez | first = David Jesse | last2 = Gumperz | first2 = Jenny E. | last3 = Ganem | first3 = Don | date = 2005-05-02 | title = Regulation of CD1d expression and function by a herpesvirus infection | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087176/ | journal = Journal of Clinical Investigation | volume = 115 | issue = 5 | pages = 1369–1378|doi=10.1172/JCI200524041|issn=0021-9738|pmc=1087176|pmid=15864354|quote=|via=}}</ref><ref>{{Cite journal | last = Chung | first = Brian K. | last2 = Tsai | first2 = Kevin | last3 = Allan | first3 = Lenka L. | last4 = Zheng | first4 = Dong Jun | last5 = Nie | first5 = Johnny C. | last6 = Biggs | first6 = Catherine M. | last7 = Hasan | first7 = Mohammad R. | last8 = Kozak | first8 = Frederick K. | last9 = van den Elzen | first9 = Peter | date = 2013-10-10 | title = Innate immune control of EBV-infected B cells by invariant natural killer T cells |url =https://www.ncbi.nlm.nih.gov/pubmed/23974196 | journal = Blood | volume = 122 | issue = 15 | pages = 2600–2608|doi=10.1182/blood-2013-01-480665|issn=1528-0020|pmid=23974196}}</ref><ref>{{Cite journal | last = Priatel | first = John J | last2 = Chung | first2 = Brian K | last3 = Tsai | first3 = Kevin | last4 = Tan | first4 = Rusung | date = 2014-04-09 | title = Natural killer T cell strategies to combat Epstein–Barr virus infection | url =https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063158/ | journal = Oncoimmunology | volume = 3|doi=10.4161/onci.28329|issn=2162-4011|pmc=4063158|pmid=25050206 | issue = | pages = |quote=|via=}}</ref> | ||
==Learn more == | ==Learn more == | ||
Latest revision as of 16:05, April 3, 2023
 | This article is a stub. |
CD1d is a glycoprotein expressed on some cells containing antigens, such as in the case of intracellular infection. They activate natural killer cells.
The gamma herpesviruses Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus evade immune system detection and persist in B cells by down regulating the expression of CD1d, enabling them to avoid immune recognition by natural killer cells.[1][2][3]
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- ↑ Sanchez, David Jesse; Gumperz, Jenny E.; Ganem, Don (May 2, 2005). "Regulation of CD1d expression and function by a herpesvirus infection". Journal of Clinical Investigation. 115 (5): 1369–1378. doi:10.1172/JCI200524041. ISSN 0021-9738. PMC 1087176. PMID 15864354.
- ↑ Chung, Brian K.; Tsai, Kevin; Allan, Lenka L.; Zheng, Dong Jun; Nie, Johnny C.; Biggs, Catherine M.; Hasan, Mohammad R.; Kozak, Frederick K.; van den Elzen, Peter (October 10, 2013). "Innate immune control of EBV-infected B cells by invariant natural killer T cells". Blood. 122 (15): 2600–2608. doi:10.1182/blood-2013-01-480665. ISSN 1528-0020. PMID 23974196.
- ↑ Priatel, John J; Chung, Brian K; Tsai, Kevin; Tan, Rusung (April 9, 2014). "Natural killer T cell strategies to combat Epstein–Barr virus infection". Oncoimmunology. 3. doi:10.4161/onci.28329. ISSN 2162-4011. PMC 4063158. PMID 25050206.
