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Aciclovir
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==Aciclovir as a treatment for ME/CFS== In 1988, [[Stephen Straus|Straus]] et al. conducted a double-blind, placebo-controlled study of the efficacy of aciclovir in patients with [[chronic fatigue syndrome|CFS]]. One group was given a course of IV aciclovir followed by oral aciclovir. The other group received a placebo. Patients with and without antibodies to [[Epstein-Barr virus]] early antigens were included in the study. The researchers concluded that aciclovir, as used in this study, did not ameliorate the symptoms of [[chronic fatigue syndrome]]: "Of the 24 patients who completed the trial, similar numbers improved with acyclovir therapy and with placebo (11 and 10, respectively). Neither acyclovir treatment nor clinical improvement correlated with alterations in laboratory findings, including titers of antibody to Epstein-Barr virus."<ref name="Straus1988">{{Cite journal | last = Straus | first = Stephen E. | author-link = Stephen Straus | last2 = Dale | first2 = Janet K. | author-link2 = | last3 = Tobi | first3 = Martin | author-link3 = | last4 = Lawley | first4 = Thomas | author-link4 = | last5 = Preble | first5 = Olivia | author-link5 = | last6 = Blaese | first6 = R. Michael | last7 = Hallahan | first7 = Claire | last8 = Henle | first8 = Werner | date = 1988-12-29 | title = Acyclovir Treatment of the Chronic Fatigue Syndrome | url =https://doi.org/10.1056/NEJM198812293192602 | journal = New England Journal of Medicine | volume = 319 | issue = 26 | pages = 1692β1698|doi=10.1056/NEJM198812293192602|issn=0028-4793|pmid=2849717|quote=|via=}}</ref>
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