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Allergy
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An '''allergy''' is a long term condition in which the [[immune system]] mounts an abnormal reaction to an ordinarily harmless substance called an allergen.<ref name="aaaai-allergy">{{Cite web | url = https://www.aaaai.org/conditions-treatments/allergies/allergies-overview | title = Allergies Overview | last = | first = | author-link = | date = | website = American Academy of Allergy, Asthma & Immunology|archive-url=|archive-date=|url-status= | access-date = 2021-10-20}}</ref> Allergic reactions vary in severity from relatively minor symptoms to [[anaphylaxis|life-threatening anaphylactic shock]].<ref name="aaaai-allergy" /> == Allergic reaction == An allergic reaction occurs when the person's immune system produces [[Immunoglobulin E]] (IgE). When the person comes into contact with an allergen, the IgE travels to cells that release [[histamine]] and other chemicals; it is the histamine that causes the allergic reaction.<ref name="aaaai-allergy" /> A severe, systemic allergic reaction is called [[anaphylaxis]] or <span class="noglossary">anaphylactic shock</span>, and can be life-threatening.<ref name="Anaphylaxis-NHS">{{Cite web | url = https://www.nhs.uk/conditions/anaphylaxis/ | title = Anaphylaxis | last = | first = | author-link = | date = 2017-10-20 | website = [[National Health Service]]|language=en | access-date = 2021-02-18}}</ref><ref name="definition">{{Cite web | url = https://www.merriam-webster.com/dictionary/anaphylactic+shock | title = Definition of ANAPHYLACTIC SHOCK | website = Merriam-Webster Dictionary|language=en | access-date = 2021-02-18}}</ref> {{See also|Anaphylaxis}} ==Prevalence == ==Symptom recognition == The onset of new allergies is a potential symptom of [[Long COVID]] in the [[World Health Organization Long COVID diagnostic criteria|World Health Organization]]'s definition.<ref name="WHO-longcovid-criteria">{{citation | title = A clinical case definition of post COVID-19 condition by a Delphi consensus | date =Oct 6, 2021 | publisher = [[World Health Organization]] | others = World Health Organization (WHO) clinical case definition working group on post COVID-19 condition | first1 = Joan B. | last1 = Soriano | first2 = Maya | last2 = Allan | first3 = Carine | last3 = Alsokhn | first4 = Nisreen A. | last4 = Alwan | author-link4 = Nisreen Alwan | first5 = Lisa | last5 = Askie | first6 = Hannah E. | last6 = Davis | author-link6 = Hannah Davis | first7 = Janet V. | last7 = Diaz | first8 = Tarun | last8 = Dua | first9 = Wouter | last9 = de Groote | first10 = Robert | last10 = Jakob | first11 = Marta | last11 = Lado | first12 = John | last12 = Marshall | first13 = Srin | last13 = Murthy | first14 = Jacobus | last14 = Preller | first15 = Pryanka | last15 = Relan | first16 = Nicoline | last16 = Schiess | first17 = Archana | last17 = Seahwag | ref = WHO reference number: WHO/2019-nCoV/Post_COVID-19_condition/Clinical_case_definition/2021.1 | url = https://www.who.int/publications-detail-redirect/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1}}</ref> == Notable studies == * 1988, Allergy and the chronic fatigue syndrome<ref name="Straus1988">{{Cite journal | last = Straus | first = S.E. | author-link = Stephen Straus | last2 = Dale | first2 = J.K. | author-link2 = | last3 = Wright | first3 = R. | author-link3 = | last4 = Metcalfe | first4 = D.D. | author-link4 = | author-link5 = | date = May 1988 | title = Allergy and the chronic fatigue syndrome | url =https://www.ncbi.nlm.nih.gov/pubmed/2836490 | journal = The Journal of Allergy and Clinical Immunology | volume = 81 | issue = 5 Pt 1 | pages = 791β795|issn=0091-6749|pmid=2836490|quote=|via=}}</ref> * 1998, Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables<ref name="Borish1998">https://www.jacionline.org/article/S0091-6749(98)70090-9/fulltext</ref> [https://www.jacionline.org/article/S0091-6749(98)70090-9/fulltext (Full text)] * 2015, Increased Risk of Chronic Fatigue Syndrome Following Atopy: A Population-Based Study<ref>{{Cite journal | last = Yang | first = Tse-Yen | author-link = | last2 = Kuo | first2 = Haung-Tsung | author-link2 = | last3 = Chen | first3 = Hsuan-Ju | author-link3 = | last4 = Chen | first4 = Chih-Sheng | author-link4 = | last5 = Lin | first5 = Wei-Ming | author-link5 = | last6 = Tsai | first6 = Shin-Yi | last7 = Kuo | first7 = Chua-Nan | last8 = Kao | first8 = Chia-Hung | date = Jul 2015 | title = Increased Risk of Chronic Fatigue Syndrome Following Atopy: A Population-Based Study | url = https://www.ncbi.nlm.nih.gov/pubmed/26200644 | journal = Medicine | volume = 94 | issue = 29| pages = e1211|doi=10.1097/MD.0000000000001211|issn=1536-5964|pmc=4603016|pmid=26200644|quote=|via=}}</ref> == See also == * [[Food sensitivities]] * [[Medicine sensitivities]] * [[Mast cell activation syndrome]] * [[Multiple chemical sensitivity]] * [[Histamine]] == Learn more == * 1999, [https://www.sciencedaily.com/releases/1999/01/990119104557.htm Allergies To Foods, Plants May Predict Chronic Fatigue Syndrome] - ScienceDaily * 2019, [https://www.smithsonianmag.com/smart-news/allergy-season-getting-longer-and-nastier-each-year-180971922/ Allergy Season Is Getting Longer and Nastier Each Year] - Smithsonian Magazine ==References== {{reflist}} [[Category:Diagnoses]] [[Category:Immunology]] [[Category:Immune signs and symptoms]] [[Category:Potential comorbidities]] [[Category:Long COVID signs and symptoms]]
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