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Autoimmune hypothesis
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==Notable studies== *2020, Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts<ref name="Bynke2020">{{Cite journal | last = Bynke | first = Annie | author-link = | last2 = Julin | first2 = Per | author-link2 = | last3 = Gottfries | first3 = Carl-Gerhard | author-link3 = Carl-Gerhard Gottfries | last4 = Heidecke | first4 = Harald | author-link4 = | last5 = Scheibenbogen | first5 = Carmen | author-link5 = Carmen Scheibenbogen | last6 = Bergquist | first6 = Jonas | author-link6 = Jonas Bergquist | date = 2020-08-01 | title = Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts |url =http://www.sciencedirect.com/science/article/pii/S2666354620300727 | journal = Brain, Behavior, & Immunity - Health|language=en|volume=7 | issue = | pages = 100107|doi=10.1016/j.bbih.2020.100107|issn=2666-3546|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [http://www.sciencedirect.com/science/article/pii/S2666354620300727 (Full text)] *2020, Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref name="Asgeir2020">{{Cite journal | last = Lande | first = Asgeir | author-link = Asgeir Lande | last2 = Fluge | first2 = Øystein | author-link2 = Øystein Fluge | last3 = Strand | first3 = Elin B. | author-link3 = Elin Strand | last4 = Flåm | first4 = Siri T. | author-link4 = Siri Flåm | last5 = Sosa | first5 = Daysi D. | author-link5 = Daysi Sosa | last6 = Mella | first6 = Olav | author-link6 = Olav Mella | last7 = Egeland | first7 = Torstein | author-link7 = | last8 = Saugstad | first8 = Ola D. | author-link8 = | last9 = Lie | first9 = Benedicte A. | author-link9 = | date = 2020-03-24 | title = Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | url = https://www.nature.com/articles/s41598-020-62157-x | journal = Scientific Reports|language=en|volume=10 | issue = 1 | pages = 1–8|doi=10.1038/s41598-020-62157-x|issn=2045-2322|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.nature.com/articles/s41598-020-62157-x (Full text)] *2018, Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model<ref name="Blomberg2018">{{Cite journal | last = Blomberg | first = Jonas | author-link = Jonas Blomberg | last2 = Gottfries | first2 = Carl-Gerhard | author-link2 = Carl-Gerhard Gottfries | last3 = Elfaitouri | first3 = Amal | author-link3 = | last4 = Rizwan | first4 = Muhammad | author-link4 = | last5 = Rosén | first5 = Anders | author-link5 = | date = 2018-02-15 | title = Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818468/ | journal = Frontiers in Immunology|volume=9 | issue = | pages = |doi=10.3389/fimmu.2018.00229|issn=1664-3224|pmc=5818468|pmid=29497420|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818468/ (Full text)] *2018, [http://10.1016/j.autrev.2018.01.009 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease]<ref name="Sotzny, 2018">{{citation | last1 = Sotzny | first1 = Franziska | author-link1 = Franziska Sotzny | last2 = Blanco | first2 = Julià | author-link2 = Julià Blanco | last3 = Capelli | first3 = Enrica | author-link3 = Enrica Capelli | last4 = Castro-Marrero | first4 = Jesús | author-link4 = Jesús Castro-Marrero | last5 =Steiner | first5 = Sophie | author-link5 = Sophie Steiner | last6 = Murovska | first6 = Modra | author-link6 = Modra Murovska | last7 = Scheibenbogen | first7 = Carmen | author-link8 = Carmen Scheibenbogen | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease | journal =Autoimmunity Reviews | volume = 17 | issue = 6 | page = 601-609 | date = 2018 | doi = 10.1016/j.autrev.2018.01.009 }}</ref> *2017-2020, Defining Autoimmune Aspects of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref name="2017trial">{{Cite web | url = https://clinicaltrials.gov/ct2/show/NCT03254823 | title = Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - Full Text View | last = | first = | author-link = | date = | website = clinicaltrials.gov|language=en|archive-url=|archive-date=|url-status= | access-date = 2020-04-25}}</ref> - [https://clinicaltrials.gov/ct2/show/NCT03254823 Clinical Trial] *2014, [http://www.ncbi.nlm.nih.gov/m/pubmed/24068616/?i=3 The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)]<ref name="Morris2014">{{Cite journal | last = Morris | first = Gerwyn | author-link = Gerwyn Morris | last2 = Berk | first2 = Michael | author-link2 = Michael Berk | last3 = Galecki | first3 = Piotr | author-link3 = Piotr Galecki | last4 = Maes | first4 = Michael | author-link4 = Michael Maes | author-link5 = | author-link6 = | date = 2014-04-01 | title = The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/cfs) | url = https://doi.org/10.1007/s12035-013-8553-0 | journal = Molecular Neurobiology|language=en|volume=49 | issue = 2 | pages = 741–756|doi=10.1007/s12035-013-8553-0|issn=1559-1182|quote=|via=}}</ref> *2013, [http://www.ncbi.nlm.nih.gov/m/pubmed/23664637/ In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation]<ref name="Maes2013">{{Cite journal | last = Maes | first = Michael | author-link = Michael Maes | last2 = Ringel | first2 = Karl | author-link2 = Karl Ringel | last3 = Kubera | first3 = Marta | author-link3 = Marta Kubera | last4 = Anderson | first4 = George | author-link4 = George Anderson | last5 = Morris | first5 = Gerwyn | author-link5 = Gerwyn Morris | last6 = Galecki | first6 = Piotr | author-link6 = Piotr Galecki | last7 = Geffard | first7 = Michel | author-link8 = Michel Geffard | date = 2013-09-05 | title = In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation | url =http://www.sciencedirect.com/science/article/pii/S0165032713002541 | journal = Journal of Affective Disorders|volume=150 | issue = 2 | pages = 223–230|doi=10.1016/j.jad.2013.03.029|issn=0165-0327|quote=|via=}}</ref> *2012, [http://www.ncbi.nlm.nih.gov/m/pubmed/22166399/ Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression]<ref name="Maes2012">{{Cite journal | last = Maes | first = Michael | author-link = Michael Maes | last2 = Ringel | first2 = Karl | author-link2 = Karl Ringel | last3 = Kubera | first3 = Marta | author-link3 = Marta Kubera | last4 = Berk | first4 = Michael | author-link4 = Michael Berk | last5 = Rybakowski | first5 = Janusz Rybakowski | author-link5 = Janusz | author-link6 = | date = 2012-02-01 | title = Increased autoimmune activity against 5-HT : a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression | url =http://dro.deakin.edu.au/view/DU:30047500 | journal = Journal of affective disorders|volume=136 | issue = 3 | pages = 386–392|doi=10.1016/j.jad.2011.11.016|issn=0165-0327|quote=|via=}}</ref> *2004, [http://www.ncbi.nlm.nih.gov/m/pubmed/15082083 Is chronic fatigue syndrome an autoimmune disorder of endogenous neuropeptides, exogenous infection and molecular mimicry?]<ref name="Staines2004">{{Cite journal | last = Staines | first = Donald R | author-link = Donald Staines | author-link2 = | date = 2004-05-01 | title = Is chronic fatigue syndrome an autoimmune disorder of endogenous neuropeptides, exogenous infection and molecular mimicry? | url = http://www.sciencedirect.com/science/article/pii/S0306987704000659 | journal = Medical Hypotheses|volume=62 | issue = 5 | pages = 646–652|doi=10.1016/j.mehy.2004.01.012|issn=0306-9877|quote=|via=}}</ref> - [[Donald Staines]]
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