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Blood-brain barrier
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{{Cleanup/Citations needed | date = 2021}} The '''blood-brain barrier''' or '''BBB''' is a selective permeable barrier composed of endothelium that separates [[central nervous system]] from circulating [[blood]]. ==Circumventricular organs == Some parts of the brain sit outside the blood brain barrier. Collectively, they are known as the [[circumventricular organs]] and include sensory and secretory organs important for [[neuroendocrine system |neuroendocrine]] function including the [[pineal gland]] and the posterior [[pituitary gland]]. The [[olfactory bulb]] also sits outside the blood brain barrier. ==Diseases== Several diseases have been associated with a weakened blood-brain barrier including [[epilepsy]] and [[multiple sclerosis]]. ==Drugs== Most drugs are unable to cross the Blood-Brain-Barrier, which restricts treatment for certain conditions.{{citation needed | date = 2021 | reason=eg brain cancer}} ==Notable research== * ==See also == *[[Blood]] *[[Neurology of ME/CFS]] *[[Neuroinflammation]] *[[Brain]] ==Notable Research== *[https://www.nature.com/articles/s41593-024-01576-9 Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment]<ref>{{Cite journal|title=Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment|date=2024-02-22|url=https://www.nature.com/articles/s41593-024-01576-9|journal=Nature Neuroscience|pages=1–12|last=Greene|first=Chris|last2=Connolly|first2=Ruairi|last3=Brennan|first3=Declan|last4=Laffan|first4=Aoife|last5=O’Keeffe|first5=Eoin|last6=Zaporojan|first6=Lilia|last7=O’Callaghan|first7=Jeffrey|last8=Thomson|first8=Bennett|last9=Connolly|first9=Emma|last10=Argue|first10=Ruth|last11=Martin-Loeches|first11=Ignacio|language=en|doi=10.1038/s41593-024-01576-9|issn=1546-1726}}</ref> ==Learn more == * [https://www.theguardian.com/society/2024/feb/22/long-covid-brain-fog-may-be-due-to-leaky-blood-brain-barrier-study?trk=public_post_comment-text Long Covid 'brain fog' may be due to leaky blood-brain barrier, study finds] The Guardian Feb 22, 2024 ==References == {{Reflist}} [[Category:Neurology]] [[Category:Anatomy]]
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