Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Butyrate
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
'''Butyrate''' is a [[short chain fatty acid]] produced in the [[large intestine]] by the [[fermentation]] of dietary [[fiber]] by commensal bacteria and is an important source of energy for colon cells. It has been studied for its possible benefits in [[inflammatory bowel disease]]s (IBDs), such as [[ulcerative colitis]] (UC) and [[Crohn's disease|Crohn’s disease]] (CD), the [[mucosal immune system]], [[intestinal motility]], hemoglobinopathies, genetic metabolic diseases, [[hypercholesterolemia]], [[obesity]] and [[insulin]] resistance, and ischemic [[stroke]].<ref name="potential2011" /> Studies [[In vitro studies|in vitro]] and in animal models have found that it decreases [[intestinal permeability]], although a 2020 study found that it did not have this effect in human tissue.<ref>{{Cite journal | title = Acute Effects of Butyrate on Induced Hyperpermeability and Tight Junction Protein Expression in Human Colonic Tissues | date = 2020-05-14 | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277647/ | journal = Biomolecules | volume = 10 | issue = 5 | pages = 766 | last = Tabat | first = Mathias W. | last2 = Marques | first2 = Tatiana M. | last3 = Markgren | first3 = Malin | last4 = Löfvendahl | first4 = Liza | last5 = Brummer | first5 = Robert J. | last6 = Wall | first6 = Rebecca|doi=10.3390/biom10050766|pmc=7277647|pmid=32422994|issn=2218-273X}}</ref> [[Sodium phenylbutyrate]] may increase [[peroxisome]] proliferation and the [[Beta-oxidation |β-oxidation]] of [[very long chain fatty acid]]s in X-linked [[Adrenoleukodystrophy]]<ref name="redundancy1998" /> Butyrate may down regulate the expression of nine genes involved in the biosynthesis of cholesterol in the [[intestine]].<ref name="expression2008" /> ==Learn more== *2016, [https://selfhacked.com/2016/05/07/health-benefits-butyrate-derivatives-sodium-butyrate-phenylbutyrate-trybutyrine-butyric-acid-butyrate-prodrugs-butyrate-producing-bacteria/ Top 21 Science-Based Health Benefits Of Butyrate And Its Derivatives] ==References== <references> <ref name="potential2011">{{Citation| doi = 10.3748/wjg.v17.i12.1519| issn = 1007-9327| volume = 17 | issue = 12| pages = 1519–1528| last1 = Canani | first1 = Roberto Berni | last2 = Costanzo | first2 = Margherita Di | last3 = Leone | first3 = Ludovica | last4 = Pedata | first4 = Monica | last5 = Meli | first5 = Rosaria | last6 = Calignano | first6 = Antonio| title = Potential beneficial effects of butyrate in intestinal and extraintestinal diseases| journal = World Journal of Gastroenterology : WJG| access-date = 2016-11-09| date = 2011-03-28| url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070119/| pmid = 21472114| pmc = 3070119}}</ref> <ref name="redundancy1998">{{Citation| doi = 10.1038/3242| issn = 1078-8956| volume = 4 | issue = 11| pages = 1261–1268| last1 = Kemp | first1 = S. | last2 = Wei | first2 = H.M. | last3 = Lu | first3 = J.F. | last4 = Braiterman | first4 = L.T. | last5 = McGuinness | first5 = M.C. | last6 = Moser | first6 = A.B. |last7 = Watkins | first7 = P.A. |last8 = Smith | first8 = K.D. | title = Gene redundancy and pharmacological gene therapy: implications for X-linked adrenoleukodystrophy| journal = Nature Medicine | date = November 1998 | pmid = 9809549}}</ref> <ref name="expression2008">{{Citation| doi = 10.1002/iub.110| issn = 1521-6551| volume = 60 | issue = 11| pages = 757–764| last1 = Alvaro | first1 = Adriana | last2 = Solà| first2 = Rosa | last3 = Rosales | first3 = Roser | last4 = Ribalta | first4 = Josep | last5 = Anguera | first5 = Anna | last6 = Masana | first6 = Lluís | last7 = Vallvé| first7 = Joan Carles| title = Gene expression analysis of a human enterocyte cell line reveals downregulation of cholesterol biosynthesis in response to short-chain fatty acids| journal = IUBMB life | date = November 2008 | pmid = 18642346}}</ref> </references> [[Category:Potential treatments]] [[Category:Fatty acids]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Citation
(
edit
)
Template:Cite journal
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:No globals
(
edit
)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs