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Central sensitization
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=== Central sensitivity syndromes === The main rationale behind the expansion of the concept of central sensitivity came from clinical practice. Some researchers<ref>{{Cite journal | last = Yunus | first = Muhammad B. | date = Jun 2008 | title = Central Sensitivity Syndromes: A New Paradigm and Group Nosology for Fibromyalgia and Overlapping Conditions, and the Related Issue of Disease versus Illness |url =http://dx.doi.org/10.1016/j.semarthrit.2007.09.003 | journal = Seminars in Arthritis and Rheumatism | volume = 37 | issue = 6 | pages = 339β352|doi=10.1016/j.semarthrit.2007.09.003|issn=0049-0172|quote= | authorlink = Muhammad Yunus|via=}}</ref><ref>{{Cite journal | last = Toda | first = Katsuhiro | date = Jan 2012 | title = The Term of Functional Somatic Syndrome Should be Changed to the Term of Central Sensitivity Syndrome | url =http://dx.doi.org/10.1111/j.1533-2500.2011.00504.x | journal = Pain Practice | volume = 12 | issue = 1 | pages = 83β83|doi=10.1111/j.1533-2500.2011.00504.x|issn=1530-7085}}</ref> speculated that central sensitization might elucidate several of the so-called β[[Medically unexplained physical symptoms|medically unexplained syndromes]] (MUS)β.Β Not only is there a significant overlap between these syndromes, but patients who suffer from it usually have a wide array of symptoms related to chronic pain. This suggested a common, previously unrecognized mechanism involving lowered thresholds to noxious stimuli, to be behind the expression of [[Medically unexplained physical symptoms|MUS]].<ref>{{Cite journal | last = Adams | first = Leah | last2 = Turk | first2 = Dennis | date = 2015-07-02 | title = Psychosocial Factors and Central Sensitivity Syndromes |url =http://dx.doi.org/10.2174/1573397111666150619095330 | journal = Current Rheumatology Reviews | volume = 11 | issue = 2 | pages = 96β108|doi=10.2174/1573397111666150619095330|issn=1573-3971}}</ref> In 2000 Muhammad Yunus suggested to group these disorders under the unifying concept of central sensitivity syndromes (CSS).<ref name="Yunus2000JIRA">{{Cite journal | last = Yunus | first = Muhammad B. | authorlink = Muhammad Yunus | date = 2000 | url = https://www.researchgate.net/publication/284292175_Central_sensitivity_syndromes_A_unified_concept_for_fibromyalgia_and_other_similar_maladies | title = Central sensitivity syndromes: a unified concept for fibromyalgia and other similar maladies | journal = JIRA | volume = 8 | issue = | pages = 27-33}}</ref> In Yunusβ vision central sensitization could explain not only the widespread and lasting hyperalgesia these patients suffered, but also a hypersensitivity to other environmental stimuli such as [[Hyperacusis|sounds]], [[Chemical sensitivities|chemicals]] and [[Photophobia|light]]. Central sensitization was thus extended beyond the somatosensory system.<ref name=":11" />
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