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Clivo-axial angle
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== Epidemiology == The average CXA in healthy or nonsymptomatic population is estimated to be approximately 150 degrees. Several studies have shown that a CXA lower than 135 degrees, a frequently used cutoff, is uncommon in the healthy population<ref name=":1">{{Cite journal | last = Botelho|first = Ricardo Vieira | last2 = Ferreira | first2 = Edson Dener Zandonadi | date = Oct 2013 | title = Angular craniometry in craniocervical junction malformation | url =https://www.ncbi.nlm.nih.gov/pubmed/23640096 | journal = Neurosurgical Review | volume = 36 | issue = 4 | pages = 603–610; discussion 610|doi=10.1007/s10143-013-0471-0|issn=1437-2320|pmc=3910287|pmid=23640096}}</ref><ref name=":2">{{Cite journal | last = Batista | first = Ulysses C. | last2 = Joaquim | first2 = Andrei F. | last3 = Fernandes | first3 = Yvens B. | last4 = Mathias | first4 = Roger N. | last5 = Ghizoni | first5 = Enrico | last6 = Tedeschi | first6 = Helder | date = Apr 2015 | title = Computed tomography evaluation of the normal craniocervical junction craniometry in 100 asymptomatic patients |url =https://www.ncbi.nlm.nih.gov/pubmed/25828499 | journal = Neurosurgical Focus | volume = 38 | issue = 4| pages = E5|doi=10.3171/2015.1.FOCUS14642|issn=1092-0684|pmid=25828499}}</ref><ref name=":3">{{Cite journal | last = Bundschuh|first = C | last2 = Modic | first2 = Mt | last3 = Kearney | first3 = F | last4 = Morris | first4 = R | last5 = Deal | first5 = C | date = 1988-07-01 | title = Rheumatoid arthritis of the cervical spine: surface-coil MR imaging | url =https://www.ajronline.org/doi/abs/10.2214/ajr.151.1.181 | journal = American Journal of Roentgenology | volume = 151 | issue = 1 | pages = 181–187|doi=10.2214/ajr.151.1.181|issn=0361-803X}}</ref> (see table below) and is associated with pathological conditions such as brainstem compression in patients with [[rheumatoid arthritis]].<ref name=":3" /> A consensus statement formed at the second International CSF Dynamics Symposium of the Chiari and Syringomyelia Foundation in 2013, proposed that a CXA lower than 135 degrees could be seen as “potentially pathological.”<ref name=":0" /> {| class="wikitable" !Study !Term !Definition !Number of healthy persons !Average CXA !standard deviation !Range |- |Bothelo & Ferreira (2013)<ref name=":1" /> |Clivo-canal angle (CCA) |The angle between the line extending from the top of the dorsum sellae to the basion and the line between the inferodorsal portions of C2 to the most superodorsal part of the dens.<ref name=":1" /> |33 |148° |± 9.8° |129°-175° |- |Batista et al. (2015)<ref name=":2" /> |Clivus-canal angle (CCA) |Measured as the angle at the intersection of a line extending from the inferior one-third of the clivus and a line extending from the inferodorsal portion of the C-2 vertebral body to the superodorsal part of the dens<ref name=":2" /> |100 |153.6° |± 7.6° |132.3°–173.9° |- |Bundschuh et al. (1987)<ref name=":3" /> |Cervicomedullary angle |Angle subtended by lines drawn parallel to the ventral surfaces of the medulla and upper cervical cord<ref name=":3" /> |50 |155.2° |± 8,7° |135°-175° |- |Asal and Hasan (2018)<ref name=":7" /> |Clivo-axial angle (CAA) |The angle between the line extending from dorsum sella to basion and the line drawn along the boundary superoposterior and inferoposterior corners of the C2 vertebrae.<ref name=":7" /> |65 |153.66° |±6.35° |139.5-169.5 |- |Nagashima and Kubota (1983)<ref name=":6">{{Cite journal | last = Nagashima | first = C. | last2 = Kubota | first2 = S. | date = 1983 | title = Craniocervical abnormalities. Modern diagnosis and a comprehensive surgical approach | url = https://www.ncbi.nlm.nih.gov/pubmed/6674836 | journal = Neurosurgical Review | volume = 6 | issue = 4 | pages = 187–197|issn=0344-5607|pmid=6674836}}</ref> |Clivo-axial angle (C-A angle) |The clivus line (line drawn along posterior surface of clivus) and the axis line (line drawn along posterior surface of axis) form the angle.<ref name=":6" /> |41 |158.2° |± 9.8° | |} === Gender === Women have increased range of motion (change in CXA from flexion to extension) than men.<ref name=":6" /> ===ME/CFS === A Swedish study of 234 ME/CFS patients meeting the [[Canadian Consensus Criteria]] found an average CXA of f 148 ±10 degrees<ref>{{Cite journal | last = Bragée | first = Björn | last2 = Michos | first2 = Anastasios | last3 = Drum | first3 = Brandon | last4 = Fahlgren | first4 = Mikael | last5 = Szulkin | first5 = Robert | last6 = Bertilson | first6 = Bo C. | date = 2020-08-28 | title = Signs of Intracranial Hypertension, Hypermobility, and Craniocervical Obstructions in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | url =https://www.frontiersin.org/article/10.3389/fneur.2020.00828/full | journal = Frontiers in Neurology | volume = 11 | pages = 828|doi=10.3389/fneur.2020.00828|issn=1664-2295}}</ref>, measured as:<blockquote>A straight line was drawn along the caudal edge of the clivus bone, and a second was drawn by extending a straight line along the posterior axial line from the base of the axis to the dens</blockquote> === Ehlers-Danlos Syndrome === A study of the CXA in patients with [[Ehlers-Danlos syndrome]] and a control group of patients with cervical spondolysis found that EDS patients had an average CXA of 139.7±10.4 degrees as compared to the control group 148.9±8.4. They also had a greater change in CXA between flexion and extension: 74.6±24.4 in the EDS group vs 39.4±11.3 in controls.<ref>{{Cite journal | last = Casey|first = A.T. | last2 = Smith | first2 = F. | last3 = Davagnanam | first3 = I. | last4 = Khan | first4 = F. | last5 = Prezerakos | first5 = G.K. | date = 2019-03-01 | title = FM1-7 Cranio-cervical instability in ehlers-danlos syndrome employing upright, dynamic MR imaging; a comparative study | url = https://jnnp.bmj.com/content/90/3/e22.2 | journal = Journal of Neurology, Neurosurgery & Psychiatry|language=en | volume = 90 | issue = 3| pages = e22–e22|doi=10.1136/jnnp-2019-ABN.69|issn=0022-3050}}</ref> === Migraine === The clivo-axial angle of 65 patients with [[migraine]] and 65 controls were compared. The mean CXA in the migraine group was 142.65 ± 8.73°, 153.66 ± 6.35° in controls.<ref name=":7">{{Cite journal | last = Şahan | first = Mehmet Hamdi | last2 = Asal | first2 = Neşe | date = 2018-12-01 | title = Is there a relationship between migraine disease and the skull base angles? | url = https://dergipark.org.tr/ortadogutipdergisi/issue/40670/411138 | journal = Ortadoğu Tıp Dergisi|language=en | volume = 10 | issue = 4 | pages = 456–470|doi=10.21601/ortadogutipdergisi.411138|quote=|via=}}</ref> === Basilar invagination === Bothelo & Ferreira (2013) documented 25 patients with [[basilar invagination]] and found a mean CXA of 120° (range 79°–145°).<ref name=":1" />
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