Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Coenzyme Q10
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
'''Coenzyme Q10''' (CoQ10) or '''ubiquinone''' is found in the [[Mitochondrion|mitochondria]] and as a component of the electron transport chain plays an important role in [[citric acid cycle|aerobic respiration]]. ==Evidence== [[File:CoQ10-NADH-fatigue-ME-CFS.jpg|alt=Improvements in fatigue scores with CoQ10 and NADH. Souce: Castro-Marrero et al. (2016), Clinical Nutrition 35(4):826-834.|thumb]] A trial of 50 mg CoQ10 taken with 5mg NADH twice daily for eight weeks found improvements in exercise performance/less exercise intolerance and a less fatigue and improved cognitive function, but those in the placebo group had better sensory and affective pain scores.<ref name="Castro2016">{{Cite journal | last = Castro-Marrero|first = Jesus | authorlink = Jesús Castro-Marrero | last2 = Sáez-Francàs | first2 = Naia | author-link2 = | last3 = Segundo | first3 = María Jose | author-link3 = | last4 = Calvo | first4 = Natalia | author-link4 = | last5 = Faro | first5 = Mónica | author-link5 = | last6 = Aliste | first6 = Luisa | author-link6 = | last7 = Fernández de Sevilla | first7 = Tomás | author-link7 = | last8 = Alegre | first8 = José | author-link8 = José Alegre | date = Aug 2016 | title = Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial | url = https://doi.org/10.1016/j.clnu.2015.07.010 | journal = Clinical Nutrition|volume=35 | issue = 4 | pages = 826–834|doi=10.1016/j.clnu.2015.07.010|issn=0261-5614|pmc=|pmid=|access-date=|quote=|via=}}</ref> Plasma CoQ10 was found to be significantly lower in [[ME/CFS]] patients than in normal controls and correlated with symptom severity.<ref name="Maes2009" /> A literature review found that CoQ10 was marginally deficient in people with chronic fatigue syndrome.<ref name="altnutrition2000">{{Cite journal | date = May 2000 | url = https://www.researchgate.net/profile/Mel-Werbach/publication/12548254_Nutritional_strategies_for_treating_chronic_fatigue_syndrome/links/59ea9d3eaca272cddddb8318/Nutritional-strategies-for-treating-chronic-fatigue-syndrome.pdf | title=Nutritional Strategies for Treating Chronic Fatigue Syndrome | journal = Alternative Medicine Review|first = Melvyn R. | last = Werbach|language=en|volume=5 | issue = 2 | pages = 93-108|quote=|via=}}</ref> Ubiquinol-10 supplementation can improve autonomic nervous function and cognitive function in chronic fatigue syndrome.<ref name="Fukuda2016" /> == Notable studies == * 2000, Nutritional Strategies for Treating Chronic Fatigue Syndrome<ref name="altnutrition2000" /> [http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.531.6116&rep=rep1&type=pdf (Full text)] * 2009, Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder<ref name="Maes2009" /> [http://www.ncbi.nlm.nih.gov/pubmed/20010505 (Abstract)] * 2016, Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome<ref name="Fukuda2016" /> [http://www.ncbi.nlm.nih.gov/pubmed/27125909 (Abstract)] * 2016,Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome – A randomized, controlled, double-blind trial<ref name="Castro2016" /> - [https://doi.org/10.1016/j.clnu.2015.07.010 (Full text)] ==Learn more== *2016, [https://cfsremission.wordpress.com/2016/04/08/coq10-b-vitamins-and-cfs/ CoQ10, B-Vitamins and CFS] *[https://www.webmd.com/vitamins/ai/ingredientmono-938/coenzyme-q10 Coenzyme Q10 Uses, Side effects and Dosage] - WebMD == See also == * [[Dr Lapp's supplement recommendations]] * [[:Category:Supplements|Supplements]] ==References== <references> <ref name="Fukuda2016">{{citation | last1 = Fukuda | first1 = S | author-link1 = Sanae Fukuda | last2 = Nojima | first2 = J | author-link2 = Junzo Nojima | last3 = Kajimoto | first3 = O | author-link3 = Osami Kajimoto | last4 = Yamaguti | first4 = K | author-link4 = Kouzi Yamaguti | last5 = Nakatomi | first5 = Y | author-link5 = Yasuhito Nakatomi | last6 = Kuratsune | first6 = H | author-link6 = Hirohiko Kuratsune | last7 = Watanabe | first7 = Y | author-link8 = Yasuyoshi Watanabe | title = Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome | journal = BioFactors (Oxford, England) | date = 2016-04-29 | pmid = 27125909 | doi = 10.1002/biof.1293 | url = http://www.ncbi.nlm.nih.gov/pubmed/27125909 }}</ref> <ref name="Maes2009">{{citation | last1 = Maes | first1 = M | author-link1 = Michael Maes | last2 = Mihaylova | first2 = I | author-link2 = Ivanka Mihaylova | last3 = Kubera | first3 = M | author-link3 = Marta Kubera | last4 = Uytterhoeven | first4 = M | author-link4 = Marc Uytterhoeven | last5 = Vrydags | first5 = N | author-link5 = Nicolas Vrydags | last6 = Bosmans | first6 = E | author-link6 = Eugene Bosmans | title = Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder | journal = Neuro Endocrinology Letters | volume = 30 | issue = 4| pages = 470–476 | date = 2009 | pmid = 20010505 | url = http://www.ncbi.nlm.nih.gov/pubmed/20010505 }}</ref> </references> [[Category:Potential treatments]] [[Category:Supplements]] [[Category:Nutrients]] [[Category:Biochemistry and cell biology]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Citation
(
edit
)
Template:Cite journal
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:No globals
(
edit
)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs