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Collagen
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==As a supplement== When hydrolyzed, collagen is reduced to small peptides, which can be ingested in the form of dietary [[:Category:Supplements|supplement]] or [[:Category:Medicinal foods|functional food]]s and beverages with the intent to aid joint and bone health and enhance skin health.<ref>{{Cite journal | last = Guillerminet | first = Fanny | last2 = Beaupied | first2 = Hélène | last3 = Fabien-Soulé | first3 = Véronique | last4 = Tomé | first4 = Daniel | last5 = Benhamou | first5 = Claude-Laurent | last6 = Roux | first6 = Christian | last7 = Blais | first7 = Anne | date = 2010-03-01 | title = Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: An in vitro and in vivo study | url = http://www.thebonejournal.com/article/S8756-3282(09)02003-1/abstract | journal = Bone|language=English|volume=46 | issue = 3 | pages = 827–834|doi=10.1016/j.bone.2009.10.035|issn=8756-3282}}</ref><ref>{{Cite journal | last = Guillerminet | first = F. | last2 = Fabien-Soulé | first2 = V. | last3 = Even | first3 = P.C. | last4 = Tomé | first4 = D. | last5 = Benhamou | first5 = C.-L. | last6 = Roux | first6 = C. | last7 = Blais | first7 = A. | date = 2012-07-01 | title = Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice | url =https://link.springer.com/article/10.1007/s00198-011-1788-6 | journal = Osteoporosis International|language=en|volume=23 | issue = 7 | pages = 1909–1919|doi=10.1007/s00198-011-1788-6|issn=0937-941X}}</ref><ref>{{Cite journal | last = Daneault | first = A. | date = 2014-04-01 | title = Hydrolyzed collagen contributes to osteoblast differentiation in vitro and subsequent bone health in vivo | url = http://www.oarsijournal.com/article/S1063-4584(14)00280-5/fulltext | journal = Osteoarthritis and Cartilage|language=English|volume=22| pages=S131|doi=10.1016/j.joca.2014.02.240|issn=1063-4584}}</ref><ref>{{Cite journal | last = Daneault | first = Audrey | last2 = Prawitt | first2 = Janne | last3 = Fabien Soulé | first3 = Véronique | last4 = Coxam | first4 = Véronique | last5 = Wittrant | first5 = Yohann | date = 2017-06-13 | title = Biological effect of hydrolyzed collagen on bone metabolism | journal = Critical Reviews in Food Science and Nutrition|volume=57 | issue = 9 | pages = 1922–1937|doi=10.1080/10408398.2015.1038377|issn=1549-7852|pmid=25976422 | url = https://zenodo.org/record/889529|url-status=live|archive-url=https://web.archive.org/web/20170913183348/https://zenodo.org/record/889529|archive-date=2017-09-13|df=}}</ref><ref>{{Cite journal | last = Jiang|first = J.X.| date = 2014 | title = Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double-blind, placebo-controlled study | url = http://old.teknoscienze.com//articles/agro-food-industry-hi-tech-collagen-peptides-improve-knee-osteoarthritis-in-elderly-women-a.aspx#.WXCW-oSGNtR | journal = Agro FOOD Industry Hi Tech|volume=25 | pages = 19–23|via=|url-status=live|archive-url=https://web.archive.org/web/20170913183401/http://old.teknoscienze.com//articles/agro-food-industry-hi-tech-collagen-peptides-improve-knee-osteoarthritis-in-elderly-women-a.aspx#.WXCW-oSGNtR|archive-date=2017-09-13}}</ref><ref>{{Cite journal | last = Dar | first = Qurratul-Ain | last2 = Schott | first2 = Eric M. | last3 = Catheline | first3 = Sarah E. | last4 = Maynard | first4 = Robert D. | last5 = Liu | first5 = Zhaoyang | last6 = Kamal | first6 = Fadia | last7 = Farnsworth | first7 = Christopher W. | last8 = Ketz | first8 = John P. | last9 = Mooney | first9 = Robert A. | date = 2017-04-06 | title = Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis |url =http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174705 | journal = PLOS ONE|volume=12 | issue = 4| pages = e0174705|doi=10.1371/journal.pone.0174705|issn=1932-6203|pmc=5383229|pmid=28384173|url-status=live|archive-url=https://web.archive.org/web/20170913184032/http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0174705|archive-date=2017-09-13|df=|bibcode=2017PLoSO..1274705D}}</ref><ref>{{Cite journal | last = Asserin | first = Jérome | last2 = Lati | first2 = Elian | last3 = Shioya | first3 = Toshiaki | last4 = Prawitt | first4 = Janne | date = 2015-12-01 | title = The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo‐controlled clinical trials |url =http://onlinelibrary.wiley.com/doi/10.1111/jocd.12174/full | journal = Journal of Cosmetic Dermatology|language=en|volume=14 | issue = 4 | pages = 291–301|doi=10.1111/jocd.12174|issn=1473-2165|url-status=live|archive-url=https://web.archive.org/web/20170910193750/http://onlinelibrary.wiley.com/doi/10.1111/jocd.12174/full|archive-date=2017-09-10}}</ref> These [[hydroxyproline]]-containing peptides are transported into the target tissues (e.g., skin, bones, and cartilage), where they act as building blocks for local cells and help boost the production of new collagen fibers.<ref>{{Cite journal | last = Ichikawa | first = Satomi | last2 = Morifuji | first2 = Masashi | last3 = Ohara | first3 = Hiroki | last4 = Matsumoto | first4 = Hitoshi | last5 = Takeuchi | first5 = Yasuo | last6 = Sato | first6 = Kenji | date = 2010-02-01 | title = Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate | url =https://dx.doi.org/10.3109/09637480903257711 | journal = International Journal of Food Sciences and Nutrition|volume=61 | issue = 1 | pages = 52–60|doi=10.3109/09637480903257711|issn=0963-7486|pmid=19961355}}</ref><ref>{{Cite journal | last = Shigemura | first = Yasutaka | last2 = Kubomura | first2 = Daiki | last3 = Sato | first3 = Yoshio | last4 = Sato | first4 = Kenji | date = 2014-09-15 | title = Dose-dependent changes in the levels of free and peptide forms of hydroxyproline in human plasma after collagen hydrolysate ingestion | url =http://www.sciencedirect.com/science/article/pii/S0308814614002763 | journal = Food Chemistry|volume=159 | pages = 328–332|doi=10.1016/j.foodchem.2014.02.091}}</ref><ref>{{Cite journal | last = Watanabe-Kamiyama | first = Mari | last2 = Shimizu | first2 = Muneshige | last3 = Kamiyama | first3 = Shin | last4 = Taguchi | first4 = Yasuki | last5 = Sone | first5 = Hideyuki | last6 = Morimatsu | first6 = Fumiki | last7 = Shirakawa | first7 = Hitoshi | last8 = Furukawa | first8 = Yuji | last9 = Komai | first9 = Michio | date = 2010-01-27 | title = Absorption and Effectiveness of Orally Administered Low Molecular Weight Collagen Hydrolysate in Rats |url =https://dx.doi.org/10.1021/jf9031487 | journal = Journal of Agricultural and Food Chemistry|volume=58 | issue = 2 | pages = 835–841|doi=10.1021/jf9031487|issn=0021-8561}}</ref>
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