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Craniocervical instability
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== Mechanical basis theory == Dozens of ME/CFS patients diagnosed with CCI (some also had EDS) reported to have experienced remarkable improvements and even remission of their ME/CFS symptoms following OCF-surgery.<ref>{{Cite web | url = https://www.mechanicalbasis.org/interviews.html | title = Craniocervical instability, Atlantoaxial Instability, Myalgic Encephalomyelitis, ME, CFS | website = MEchanical Basis|language=en|access-date=2019-06-06}}</ref><ref>{{Cite web | url = https://medium.com/@jenbrea/health-update-3-my-me-is-in-remission-dd575e650f71 | title = Health update #3: My ME is in remission | last = Brea | first = Jennifer | date = 2019-05-20 | website = Medium|access-date=2019-06-03}}</ref> They speculate that mechanical compression of the brainstem due to CCI, or other underlying structural conditions, have the potential to cause characteristic ME/CFS symptoms such as post-exertional malaise, although there have not been any studies regarding this particular theory. Some have raised concerns about CCI surgery in patients with ME/CFS given the lack of research on OCF in this patient population.<ref>{{Cite web | url = https://www.s4me.info/threads/concerns-about-craniocervical-instability-surgery-in-me-cfs.9638/ | title = Concerns about craniocervical instability surgery in ME/CFS | website = Science for ME|language=en-US|access-date=2019-06-03}}</ref>
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