Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Diagnostic biomarker
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
==Cerebrospinal fluid == ===Orosomucoid=== [[Orosomucoid]] (ORM) is a protein which has many biological activities including modulating immunity. In 2016, a study with Yang, et al, showed that the serum level of ORM in individuals with CFS was consistently elevated compared with that from healthy volunteers. The serum cortisol level in these same CFS patients was moderately decreased, indicating that "ORM increase is not a direct result of stress response."<ref name="Yang, 2016" /> Orosomucoid 2 is one of the proteins [[James Baraniuk |Baraniuk]], et al, found in a unique CFS β related [[proteome]] when studying pooled [[cerebrospinal fluid]] of CFS patients.<ref name="Baraniuk, 2005" /> Obstacles in use: Further testing needed for confirmation. ===Proteome in cerebrospinal fluid=== Analysis of the proteome (complement of proteins) in cerebrospinal fluid specimens by [[James Baraniuk | Baraniuk]], et al, in 2005, showed one, consistent CFS-related proteome compared to a group with Gulf War Illness and to controls. They found the presence of 10 proteins in cerebrospinal fluid that were shared by patients with CFS, but were not detected in control samples."<ref name="Baraniuk, 2005" /> A similar study of proteome analysis of cerebrospinal fluid was done in 2011 by [[Steven Schutzer]], et al. His group compared the pooled cerebrospinal fluid specimens of patients with CFS to patients with Neurologic [[Lyme disease|Post Treatment Lyme disease]] (nPTLS) and to healthy controls. The cerebrospinal fluid proteome of the three groups were markedly unique for each group. Although nPTLS and CFS have similar clinical presentations, the researchers were able to distinguish the two syndromes from each other via data analysis.<ref name="Schutzer, 2011" /> Obstacles in use: The specialized laboratory equipment needed for this test is usually only available in facilities engaged in research. The samples were pooled specimens. The presence of these proteins in one patient may be too small for average laboratory equipment to detect. Specific proteins to be used for a biomarker have not been identified. [[Cerebrospinal spinal fluid]] samples are obtained via spinal taps which are considered invasive and come with potential side effects.
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs