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Diagnostic biomarker
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===Proteome in cerebrospinal fluid=== Analysis of the proteome (complement of proteins) in cerebrospinal fluid specimens by [[James Baraniuk | Baraniuk]], et al, in 2005, showed one, consistent CFS-related proteome compared to a group with Gulf War Illness and to controls. They found the presence of 10 proteins in cerebrospinal fluid that were shared by patients with CFS, but were not detected in control samples."<ref name="Baraniuk, 2005" /> A similar study of proteome analysis of cerebrospinal fluid was done in 2011 by [[Steven Schutzer]], et al. His group compared the pooled cerebrospinal fluid specimens of patients with CFS to patients with Neurologic [[Lyme disease|Post Treatment Lyme disease]] (nPTLS) and to healthy controls. The cerebrospinal fluid proteome of the three groups were markedly unique for each group. Although nPTLS and CFS have similar clinical presentations, the researchers were able to distinguish the two syndromes from each other via data analysis.<ref name="Schutzer, 2011" /> Obstacles in use: The specialized laboratory equipment needed for this test is usually only available in facilities engaged in research. The samples were pooled specimens. The presence of these proteins in one patient may be too small for average laboratory equipment to detect. Specific proteins to be used for a biomarker have not been identified. [[Cerebrospinal spinal fluid]] samples are obtained via spinal taps which are considered invasive and come with potential side effects.
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