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==Notable studies== *2011, Immunological abnormalities as potential [[biomarker]]s in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref>{{Cite journal | last1 = Brenu | first1 = EW | author-link1 = Ekua Brenu | last2 = van Driel | first2 = ML | authorlink2 = | last3 = Staines | first3 = DR | authorlink3 = Donald Staines | last4 = Ashton | first4 = KJ | authorlink4 = | last5 = Ramos | first5 = SB | authorlink5 = Sandra Ramos | last6 = Keane | first6 = J | author-link6 = | last7 = Klimas | first7 = NG | author-link8 = Nancy Klimas | last8 =Marshall-Gradisnik | first8 = SM | author-link8 = Sonya Marshall-Gradisnik | title = Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis|journal = Journal of Translational Medicine|volume =9|issue = 81| page =| date = 2011| doi= 10.1186/1479-5876-9-81}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120691/ (Full Text)] *2012, The Effects of [[Influenza vaccine|Influenza Vaccination]] on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref>{{cite journal | last = Brenu | first1 = Ekua W | author-link1 = Ekua Brenu | last2 = van Driel | first2 = Mieke L | authorlink2 = | last3 = Staines | first3 = Donald R | authorlink3 = Donald Staines | last4 = Kreijkamp-Kaspers | first4 = Sanne | authorlink4 = | last5 = Hardcastle | first5 = Sharni L | authorlink5 = Sharni Hardcastle | last6 = Marshall-Gradisnik | first6 = Sonya M | author-link6 = Sonya Marshall-Gradisnik | title = The Effects of Influenza Vaccination on Immune Function in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis | journal = International Journal of Clinical Medicine|volume=3|issue=6 | page = 544-551| date = 2012 | doi = 10.4236/ijcm.2012.36098 | url = https://file.scirp.org/pdf/IJCM20120600017_29918208.pdf}}</ref> - [https://file.scirp.org/pdf/IJCM20120600017_29918208.pdf (Full Text)] *2014, Characterization of [[Natural killer cell|Natural Killer Cell]] Phenotypes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref name="Huth, 2014">{{Cite journal | last = Huth | first1 = Teilah K. | author-link1 = Teilah Huth | last2 = Brenu | first2 = Ekua | authorlink2 = Ekua Brenu | last3 =Nguyen | first3 = Thao | authorlink3 = | last4 = Hardcastle | first4 = Sharni L. | authorlink4 = Sharni Hardcastle | last5 = Johnston | first5 = Samantha| authorlink5 = Samantha Johnston | last6 = Ramos | first6 = Sandra | author-link6 = Sandra Ramos | last7 =Staines | first7 = Donald R. | author-link8 = Donald Staines | last8 =Marshall-Gradisnik | first8 = Sonya M. | author-link8 = Sonya Marshall-Gradisnik | title = Characterization of Natural Killer Cell Phenotypes in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis| journal = Journal of Clinical & Cellular Immunology | volume = 5 | issue = 3 | pages = | date = 2014 | pmid = | doi = 10.4172/2155-9899.1000223}}</ref> - [https://www.omicsonline.org/open-access/characterization-of-natural-killer-cell-phenotypes-in-chronic-fatigue-syndrome-2155-9899.1000223.pdf (Full Text)] *2014, The Role of Adaptive and Innate Immune Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref name="BrenuEW2014">{{cite journal | last1 = Brenu | first1 = EW | author-link1 = Ekua Brenu | last2 = Huth | first2 = TK | authorlink2 = Teilah Huth | last3 =Hardcastle | first3 = SL | authorlink3 = Sharni Hardcastle | last4 = Fuller | first4 = K | authorlink4 = | last5 = Kaur | first5 = M | authorlink5 = | last6 = Johnston | first6 = S | author-link6 = Samantha Johnston | last7 =Ramos | first7 = S | author-link8 = Sandra Ramos | last8 =Staines | first8 = D | author-link8 = Donald Staines | last9 =Marshall-Gradisnik | first9 = S | author-link9 = Sonya Marshall-Gradisnik | title = The Role of adaptive and innate immune cells in chronic fatigue syndrome/myalgic encephalomyelitis | journal = International Immunology | year = 2014 | volume = 26 | issue = 4 | pages = 233-42 | pmid = 24343819 | doi = 10.1093/intimm/dxt068}}</ref> - [https://www.researchgate.net/publication/259350347_The_Role_of_Adaptive_and_Innate_Immune_Cells_in_Chronic_Fatigue_Syndrome_Myalgic_Encephalomyelitis (Full Text)] *2014, The role of clinical guidelines for chronic fatigue syndrome/myalgic encephalomyelitis in research settings<ref>{{Cite journal | last = Johnston | first = S.C. | authorlink = Samantha Johnston | last2 = Brenu | first2 = E.W. | authorlink2 = Ekua Brenu | last3 = Staines | first3 =D.R. | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = S.M. | authorlink4 = Sonya Marshall-Gradisnik | date = 2014-01-02 | title = The role of clinical guidelines for chronic fatigue syndrome/myalgic encephalomyelitis in research settings |url =http://www.tandfonline.com/doi/abs/10.1080/21641846.2013.860779|journal = Fatigue: Biomedicine, Health & Behavior |language=en|volume=2|issue=1 | pages = 28–39|doi=10.1080/21641846.2013.860779|issn=2164-1846|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [http://www.tandfonline.com/doi/full/10.1080/21641846.2013.860779 (Abstract)] *2014, Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis ([[CFS/ME]])<ref <ref name="Hardcastle, 2014">{{Cite journal | last1 = Hardcastle | first1 = Sharni L. | author-link1 = Sharni Hardcastle | last2 = Brenu | first2 = Ekua W. | authorlink2 = Ekua Brenu | last3 =Johnston | first3 = Samantha | authorlink3 = Samantha Johnston | last4 = Nguyen | first4 = Thao | authorlink4 = | last5 = Huth | first5 = Teilah K. | authorlink5 = Teilah Huth | last6 = Kaur | first6 = Manprit| author-link6 = | last7 =Ramos | first7 = Sandra | author-link8 = Sandra Ramos | last8 =Salajegheh | first8 = Ali | author-link8 = | last9 =Staines | first9 = Donald R. | author-link9 = Donald Staines | last10 = Marshall-Gradisnik | first10 = Sonya | author-link10 = Sonya Marshall-Gradisnik | title = Analysis of the Relationship between Immune Dysfunction and Symptom Severity in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) | journal = Journal of Clinical & Cellular Immunology | volume = 5 | issue = 190 | pages = | date = 2014 | pmid = | doi = 10.4172/2155-9899.1000190}}</ref> - [https://www.omicsonline.org/open-access/analysis-relationship-immune-dysfunction-symptom-severity-patients-chronic-fatigue-2155-9899.1000190.php?aid=22894 (Full Text)] *2015, A Comparison of [[Cytokine]] Profiles of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and [[Multiple Sclerosis]] Patients<ref name="Wong, 2015">{{Cite journal | last = Wong | first1 = Naomi | author-link1 = | last2 = Nguyen | first2 = Thao | authorlink2 = | last3 =Brenu | first3 = Ekua Weba | authorlink3 = Ekua Brenu | last4 = Broadley | first4 = Simon | authorlink4 = | last5 = Staines | first5 = Donald | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik | title = A Comparison of Cytokine Profiles of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis Patients| journal = International Journal of Clinical Medicine | volume = 6 | issue = 10 | pages = 769-783 | date = 2015 | pmid = | doi = 10.4236/ijcm.2015.610103 }}</ref> *2015, [[Metabolic]] profiling reveals anomalous [[Portal:Energy metabolism|energy metabolism]] and [[Neuroinflammation|oxidative stress]] pathways in chronic fatigue syndrome patients<ref>{{Cite journal | last1 = Armstrong | first1 = Christopher W. | authorlink = Christopher Armstrong | last2 = McGregor | first2 = Neil R. | authorlink2 = Neil McGregor | last3 = Lewis | first3 = Donald P. | authorlink3 = Donald Lewis | last4 = Butt | first4 = Henry L. | authorlink4 = Henry Butt | last5 = Gooley | first5 = Paul R. | authorlink5 = Paul Gooley | title = Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients|journal=Metabolomics|volume=11|issue=6 | page = 1626–1639 | date = 2015 | doi=10.1007/s11306-015-0816-5}}</ref> - [https://link.springer.com/article/10.1007%2Fs11306-015-0816-5 (Abstract)] *2015, Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients<ref name="Hardcastle, 09052015">{{Cite journal | last1 = Hardcastle | first1 = SL | author-link1 = Sharni Hardcastle | last2 = Brenu | first2 = EW | authorlink2 = Ekua Brenu | last3 =Johnston | first3 = S | authorlink3 = Samantha Johnston | last4 = Nguyen | first4 = T | authorlink4 = | last5 = Huth | first5 = T | authorlink5 = Teilah Huth | last6 = Wong | first6 = N | author-link6 = | last7 =Ramos | first7 = S | author-link8 = Sandra Ramos | last8 =Staines | first8 = DR | author-link8 = Donald Staines | last9 =Marshall-Gradisnik | first9 = SM | author-link9 = Sonya Marshall-Gradisnik | title = Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients | journal = International Journal of Medical Sciences | volume = 12 | issue = 10 | pages = 764-772 | date = 2015 | doi = 10.7150/ijms.12399}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615236/ (Full Text)] *2015, Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients<ref name="Marshall-Gradisnik, 2015">{{Cite journal | last1 = Marshall-Gradisnik | first1 = Sonya M. | author-link1 = Sonya Marshall-Gradisnik | last2 = Smith | first2 = Peter | authorlink2 = | last3 =Brenu | first3 = Ekua W. | authorlink3 = Ekua Brenu | last4 = Nilius | first4 = Bernd | authorlink4 = | last5 = Ramos | first5 = Sandra B. | authorlink5 = | last6 = Staines | first6 = Donald R. | author-link6 = Donald Staines | title = Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients | journal = Immunology and Immunogenetics Insights | volume = 2015 | issue = 7 | pages = 1-6 | date = 2015 | pmid = | doi = 10.4137/III.S25147| url = http://insights.sagepub.com/examination-of-single-nucleotide-polymorphisms-snps-in-transient-recep-article-a4824}}</ref> - [http://journals.sagepub.com/doi/full/10.4137/III.S25147 (Full Text)] *2015, Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)<ref name="Hardcastle, 2015">{{Cite journal | last1 = Hardcastle | first1 = SL | author-link1 = Sharni Hardcastle | last2 = Brenu | first2 = EW | authorlink2 = Ekua Brenu | last3 =Johnston | first3 = S | authorlink3 = Samantha Johnston | last4 = Nguyen | first4 = T | authorlink4 = | last5 = Huth | first5 = T | authorlink5 = Teilah Huth | last6 = Wong | first6 = N | author-link6 = | last7 =Ramos | first7 = S | author-link8 = Sandra Ramos | last8 =Staines | first8 = DR | author-link8 = Donald Staines | last9 =Marshall-Gradisnik | first9 = SM | author-link9 = Sonya Marshall-Gradisnik | title = Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)| journal = BMC Immunology | volume = 16 | issue = 35 | pages = | date = 2015 | doi = 10.1186/s12865-015-0101-4}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450981/ (Full Text)] *2015, Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref name="Hardcastle, 092015">{{Cite journal | last1 = Hardcastle | first1 = Sharni Lee | author-link1 = Sharni Hardcastle | last2 = Brenu | first2 = Ekua Weba | authorlink2 = Ekua Brenu | last3 =Johnston | first3 = Samantha| authorlink3 = Samantha Johnston | last4 = Nguyen | first4 = Thao | authorlink4 = | last5 = Huth | first5 = Teilah | authorlink5 = Teilah Huth | last6 = Ramos | first6 = Sandra | author-link6 = Sandra Ramos | last7 =Staines | first7 = Donald | author-link8 = Donald Staines | last8 =Marshall-Gradisnik | first8 = Sonya | author-link8 = Sonya Marshall-Gradisnik | title = Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients| journal = Journal of Translational Medicine | volume = 13 | issue = 299 | pages = | date = 2015 | doi = 10.1186/s12967-015-0653-3}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568602/ (Full Text)] *2015, Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref name="Peterson, 2015">{{Cite journal | last1 = Peterson | first1 = D | author-link1 = Daniel Peterson | last2 = Brenu | first2 = EW | authorlink2 = Ekua Brenu | last3 = Gottschalk | first3 = G | authorlink3 = Gunnar Gottschalk | last4 = Ramos | first4 = Sandra B | authorlink4 = Sandra Ramos | last5 = Nguyen | first5 = T | authorlink5 = | last6 = Staines | first6 = D | author-link6 = Donald Staines | last7 =Marshall-Gradisnik | first7 = S | author-link8 = Sonya Marshall-Gradisnik | title = Cytokines in the Cerebrospinal Fluids of Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis| journal = Mediators of Inflammation | volume = 2015 | issue = | pages = | date = 2015 | doi = 10.1155/2015/929720}}</ref> *2016, Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients<ref name="Huth,TK, 2016">{{Cite journal | last1 = Huth | first1 = T.K. | author-link1 = Teilah Huth | last2 = Brenu | first2 = E.W. | authorlink2 = Ekua Brenu | last3 = Staines | first3 =D.R. | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = S.M. | authorlink4 = Sonya Marshall-Gradisnik | title = Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients | journal = Gene Regulation and Systems Biology | volume = 10 | issue = | pages = 43–49| date = 2016 | pmid = | doi = 10.4137/GRSB.S39861}}</ref> - [http://www.la-press.com/redirect_fi...enotype-and-Haplotype-Invest.pdf&fileType=pdf (Full Text)] *2016, A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref name="Collatz, 2016">{{Cite journal | last1 = Collatz | first1 = Ansel | author-link1 = | last2 = Johnston | first2 = Samantha C. | authorlink2 =Samantha Johnston | last3 = Staines | first3 = Donald R. | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya M. | authorlink4 = Sonya Marshall-Gradisnik | title = A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis |journal = Clinical Therapeutics | volume =38 | issue = 6 | pages = 1263-1271.e9 | date = 2016 | pmid = 27229907 | doi = 10.1016/j.clinthera.2016.04.038}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/27229907 (Abstract)] *2016, Progressive [[brain]] changes in patients with chronic fatigue syndrome: A longitudinal MRI study<ref name="Shan, 2016">{{Cite journal | last1 = Shan | first1 = Zack Y. | author-link1 =Zack Shan | last2 = Kwiatek | first2 = Richard | authorlink2 = Richard Kwiatek | last3 =Burnet | first3 = Richard | authorlink3 =Richard Burnet | last4 = Del Fante | first4 = Peter | authorlink4 =Peter Del Fante | last5 = Staines | first5 = Donald R. | authorlink5 = Donald Staines | last6 = Marshall‐Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik | last7 =Barnden | first7 = Leighton R. | author-link8 =Leighton Barnden | title = Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study | journal = Journal of Magnetic Resonance Imaging | volume = 44 | issue = | pages = 1301–1311 | date = 2016 | pmid = | doi = 10.1002/jmri.25283}}</ref> - [https://www.scienceopen.com/document/read?vid=ac2948b6-48d1-4ebd-8f96-3a3c5a57f770 (Full Text)] *2016, [[Regulatory T cell|Regulatory T]], [[Natural killer T cell|natural killer T]] and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison<ref name="Ramos, 2016">{{Cite journal | last = Ramos | first1 = S | author-link1 = Sandra Ramos | last2 = Brenu | first2 = E | authorlink2 = Ekua Brenu | last3 =Broadley | first3 = S | authorlink3 = | last4 = Kwiatek | first4 = R | authorlink4 = Richard Kwiatek | last5 = Ng | first5 = J | authorlink5 = | last6 = Nguyen | first6 = T | author-link6 = | last7 =Freeman | first7 = S | author-link7 = | last8 =Staines | first8 = D | author-link8 = Donald Staines | last9 =Marshall-Gradisnik | first9 = S | author-link9 = Sonya Marshall-Gradisnik | title = Regulatory T, natural killer T and γδ T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison | journal = Asian Pac J Allergy Immunol | volume = | issue = | pages = | date = March 20, 2016 | doi = 10.12932/AP0733}}</ref> - [http://apjai-journal.org/wp-content/uploads/2016/12/8RegulatoryTnaturalkillerAPJAIVol34No4December2016P300.pdf (Full Text)] *2016, ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref name="Huth, 2016">{{Cite journal | last = Huth | first1 = Teilah K. | author-link1 = Teilah Huth | last2 = Staines | first2 = Donald | authorlink2 = Donald Staines | last3 =Marshall-Gradisnik | first3 = Sonya | authorlink3 = Sonya Marshall-Gradisnik| title = ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients| journal = Journal of Translational Medicine | volume = 14 | issue = 97 | pages = | date = 2016 | pmid = | doi = 10.1186/s12967-016-0859-z}}</ref> - [http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0859-z (Full Text)] *2016, [[Natural killer cell]]s and single nucleotide polymorphisms of specific [[Ion transportation|ion channels]] and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome<ref name="Marshall-Gradisnik,SM 2016">{{Cite journal | last1 = Marshall-Gradisnik | first1 = Sonya M. | author-link1 =Sonya Marshall-Gradisnik | last2 = Huth | first2 = Teilah | authorlink2 = Teilah Huth | last3 =Chacko | first3 = Anu | authorlink3 = Ekua Brenu | last4 = Johnston | first4 = Samantha | authorlink4 = Samantha Johnston | last5 = Smith | first5 = Peter | authorlink5 = | last6 = Staines | first6 = Donald R. | author-link6 = Donald Staines | title = Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome| journal = The Application of Clinical Genetics | volume = 9 | issue = | pages = 39—47 | date = 2016 | pmid = | doi = 10.2147/TACG.S99405}}</ref> - [https://www.dovepress.com/natural-killer-cells-and-single-nucleotide-polymorphisms-of-specific-i-peer-reviewed-fulltext-article-TACG (Full Text)] *2017, Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review<ref>{{Cite journal | last = Campagnolo | first = N. | last2 = Johnston | first2 = S. | authorlink2 = Samantha Johnston | last3 = Collatz | first3 = A. | last4 = Staines | first4 =D. | authorlink4 = Donald Staines | last5 = Marshall-Gradisnik | first5 = S. | authorlink5 = Sonya Marshall-Gradisnik | date = 22 Jan 2017 | title = Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review | url =http://doi.wiley.com/10.1111/jhn.12435|journal=Journal of Human Nutrition and Dietetics|language=en|volume=30|issue=3 | pages = 247–259|doi=10.1111/jhn.12435|issn=0952-3871|pmc=|pmid=28111818|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434800/ (Full Text)] *2017, Impaired [[calcium]] mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels<ref name="Nguyen, 2017">{{Cite journal | last1 = Nguyen | first1 = T. | author-link1 = | last2 = Hardcastle | first2 = S. | authorlink2 = Sharni Hardcastle | last3 =Clarke | first3 = L. | authorlink3 = | last4 = Smith | first4 = P. | authorlink4 = | last5 = Staines | first5 =D. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = S. | author-link6 = Sonya Marshall-Gradisnik | title = Impaired calcium mobilization in natural killer cells from chronic fatigue syndrome/myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels | journal = Clinical and Experimental Immunology | volume = 187 | issue = 2 | pages = 284–293 | date = 2017| doi = 10.1111/cei.12882}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217865/ (Full Text)] *2017, Novel characterisation of [[mast cell]] phenotypes from [[Peripheral blood mononuclear cell|peripheral blood mononuclear cells]] in chronic fatigue syndrome/myalgic encephalomyelitis patients<ref name="Nguyen, et al, 2017">{{Cite journal | last1 = Nguyen | first1 = T. | authorlink = | last2 = Johnston | first2 = S. | authorlink2 = Samantha Johnston | last3 = Chacko | first3 = A. | authorlink3 = | last4 = Gibson | first4 =D. | authorlink4 = | last5 = Cepon | first5 = J. | authorlink5 = | last6 = Smith | first6 =D. | author-link6 = | last7 = Staines | first7 =D. | author-link8 = Donald Staines | last8 = Marshall-Gradisnik | first8 = S. | author-link8 = Sonya Marshall-Gradisnik | title = Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients|journal=Asian Pac J Allergy Immunol|volume=35|issue=2 | page = 75-81 | date = 2017 | doi=10.12932/AP0771}}</ref> - [http://apjai-journal.org/wp-content/uploads/2017/07/75-81-AP0771.pdf (Full Text)] *2018, Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis<ref>{{Cite journal | last = Marshall-Gradisnik | first = Sonya | authorlink = Sonya Marshall-Gradisnik | last2 = Fretel | first2 = Marshall | last3 = Eaton | first3 = Natalie | authorlink3 = Natalie Eaton-Fitch | last4 = Cabanas | first4 = Helene | authorlink4 = Hélène Cabanas | last5 = Balinas | first5 = Cassandra | last6 = Gopalan | first6 = Vinod | last7 = Petersen | first7 = Daniel | author-link8 = Daniel Peterson | last8 = Passmore | first8 = Rachel | last9 = Tang | first9 = Kevin | last10 = Haque | first10 = Mazhar | author-link10 = | last11 = Lam | first11 = Alfred | author-link11 = | last12 = Staines | first12 = Donald | author-link12 = Donald Staines | date = 2018-05-31 | title = Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis |url =http://www.scirp.org/journal/PaperInformation.aspx?PaperID=85005&#abstract|journal=International Journal of Clinical Medicine|language=en|volume=09|issue=05 | pages = 467|doi=10.4236/ijcm.2018.95040|via=}}</ref> - [http://file.scirp.org/Html/11-2101759_85005.htm (Full text)] *2018, Brain function characteristics of chronic fatigue syndrome: A task [[Functional magnetic resonance imaging|fMRI]] study<ref name="Shan, 2018">{{Cite journal | last1 = Shan | first1 = Zack Y. | author-link1 = | last2 = Finegan | first2 = Kevin | authorlink2 = | last3 =Bhuta | first3 = Sandeep | authorlink3 = | last4 = Ireland | first4 = Timothy | authorlink4 = | last5 = Staines | first5 = Donald R. | authorlink5 = Donald Staines | last6 = Marshall‐Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik | last7 =Barnden | first7 = Leighton R. | author-link8 = | title = Brain function characteristics of [[chronic fatigue syndrome]]: A task fMRI study | journal = NeuroImage: Clinical | volume = 19 | issue = | pages = 279-286 | date = 2018 | pmid = | doi = 10.1016/j.nicl.2018.04.025}}</ref> - [https://www.sciencedirect.com/science/article/pii/S2213158218301347 (Full Text)] *2018, A Systematic Review of [[Probiotic]] Interventions for Gastrointestinal Symptoms and [[Irritable bowel syndrome|Irritable Bowel Syndrome]] in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)<ref name="Corbitt, 2018">{{Cite journal | last1 = Corbitt | first1 = M | author-link1 = | last2 = Campagnolo | first2 = N | authorlink2 = | last3 = Staines | first3 = D | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = S | authorlink4 = Sonya Marshall-Gradisnik | title = A Systematic Review of Probiotic Interventions for Gastrointestinal Symptoms and Irritable Bowel Syndrome in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)| journal = Probiotics Antimicrob Proteins | volume = | issue = | pages = | date = 2018 | pmid = | doi = 10.1007/s12602-018-9397-8}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/29464501 (Abstract)] *2018, A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis<ref>{{Cite journal | last = Du Preez | first = S. | authorlink = | last2 = Corbitt | first2 = M. | authorlink2 = | last3 = Cabanas | first3 = H. | authorlink3 = Hélène Cabanas | last4 = Eaton | first4 = N. | authorlink4 = Natalie Eaton-Fitch | last5 = Staines | first5 =D. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = S. | author-link6 = Sonya Marshall-Gradisnik | date = 2018-12-20 | title = A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis |url =https://doi.org/10.1186/s13643-018-0909-0|journal=Systematic Reviews|volume=7|issue=1 | pages = 241|doi=10.1186/s13643-018-0909-0|issn=2046-4053|pmc=|pmid=30572962|quote=|via=}}</ref> - [https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-018-0909-0 (Full text)] *2018, [[Rituximab]] impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation<ref name="Eaton, 2018">{{cite journal | last1 = Eaton | first1 = Natalie | author-link1 = Natalie Eaton-Fitch | last2 = Cabanas | first2 = Hélène | authorlink2 = Hélène Cabanas | last3 = Balinas | first3 = Cassandra | authorlink3 = | last4 = Klein | first4 = Anne | authorlink4 = | last5 = Staines | first5 = Donald R. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik| title = Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation| journal = BMC Pharmacology & Toxicology | year = 2018 | volume = 19 | issue = 12 | pages = | pmid = 29587879 | doi = 10.1186/s40360-018-0203-8}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870391/ (Full Text)] *2018, Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/chronic fatigue syndrome patients: A preliminary investigation<ref name="Nguyen, 2018">{{Cite journal | last1 = Nguyen | first1 = T. | authorlink = | last2 = Staines | first2 =D. | authorlink2 = Donald Staines | last3 = Johnston | first3 = S. | authorlink3 = Samantha Johnston | last4 = Marshall-Gradisnik | first4 = S. | authorlink4 = Sonya Marshall-Gradisnik| title =Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/chronic fatigue syndrome patients: A preliminary investigation| journal=Asian Pac J Allergy Immunol|volume=|issue=| page = | date = Jul 2018|doi=10.12932/AP-011117-0188}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/29981562 (Abstract)] *2018, Hyperintense sensorimotor T1 spin echo [[MRI]] is associated with [[brainstem]] abnormality in chronic fatigue syndrome<ref>{{Cite journal | last = Barnden | first = Leighton R. | last2 = Shan | first2 = Zack Y. | last3 = Staines | first3 = Donald R. | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya | authorlink4 = Sonya Marshall-Gradisnik | last5 = Finegan | first5 = Kevin | last6 = Ireland | first6 = Timothy | last7 = Bhuta | first7 = Sandeep | date = 2018 | title = Hyperintense sensorimotor T1 spin echo MRI is associated with brainstem abnormality in chronic fatigue syndrome | url =https://www.sciencedirect.com/science/article/pii/S2213158218302237|journal=NeuroImage: Clinical|volume=20 | pages = 102-109|doi=10.1016/j.nicl.2018.07.011|via=}}</ref> - [https://www.sciencedirect.com/science/article/pii/S2213158218302237 (Full Text)] *2018, Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref>{{Cite journal | last = Cabanas | first = Hélène | authorlink = Hélène Cabanas | last2 = Muraki | first2 = Katsuhiko | last3 = Eaton | first3 = Natalie | last4 = Balinas | first4 = Cassandra | last5 = Staines | first5 = Donald | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik | date = 2018-08-14 | title = Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients |url =https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0046-1|journal=Molecular Medicine|language=en|volume=24|issue=1 | pages = |doi=10.1186/s10020-018-0046-1|issn=1076-1551|via=}}</ref> - [https://molmed.biomedcentral.com/articles/10.1186/s10020-018-0046-1 (Full Text)] *2019, Prevalence and characteristics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in Poland: a cross-sectional study<ref>{{Cite journal | last = Słomko | first = Joanna | authorlink = | last2 = Newton | first2 = Julia L | authorlink2 = Julia Newton | last3 = Kujawski | first3 = Sławomir | authorlink3 = | last4 = Tafil-Klawe | first4 = Małgorzata | authorlink4 = | last5 = Klawe | first5 = Jacek | authorlink5 = | last6 = Staines | first6 = Donald | author-link6 = Donald Staines | last7 = Marshall-Gradisnik | first7 = Sonya | author-link8 = Sonya Marshall-Gradisnik | last8 = Zalewski | first8 = Pawel | date = Mar 2019 | title = Prevalence and characteristics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) in Poland: a cross-sectional study | url = http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-023955|journal=BMJ Open|language=en|volume=9|issue=3| pages = e023955|doi=10.1136/bmjopen-2018-023955|issn=2044-6055|pmc=|pmid=30850404|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429942/ (Full text)] *2019, Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients<ref>{{Cite journal | last = Cabanas | first = H. | authorlink = Hélène Cabanas | last2 = Muraki | first2 = K. | authorlink2 = | last3 = Balinas | first3 = C. | authorlink3 = | last4 = Eaton-Fitch | first4 = N. | authorlink4 = Natalie Eaton-Fitch | last5 = Staines | first5 =D. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = S. | author-link6 = Sonya Marshall-Gradisnik | date = Dec 2019 | title = Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients |url =https://molmed.biomedcentral.com/articles/10.1186/s10020-019-0083-4|journal=Molecular Medicine|language=en|volume=25|issue=1 | pages = |doi=10.1186/s10020-019-0083-4|issn=1076-1551|quote=|via=}}</ref> - [https://link.springer.com/article/10.1186/s10020-019-0083-4 (Full text)] *2019, A systematic review of [[cytokines]] in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID)<ref>{{Cite journal | last = Corbitt | first = Matthew | authorlink = | last2 = Eaton-Fitch | first2 = Natalie | authorlink2 = Natalie Eaton-Fitch | last3 = Staines | first3 = Donald | authorlink3 = Donald Staines | last4 = Cabanas | first4 = Hélène | authorlink4 = Hélène Cabanas | last5 = Marshall-Gradisnik | first5 = Sonya | authorlink5 = Sonya Marshall-Gradisnik | date = Dec 2019 | title = A systematic review of cytokines in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID) | url = https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1433-0|journal=BMC Neurology|language=en|volume=19|issue=1 | pages = |doi=10.1186/s12883-019-1433-0|issn=1471-2377|pmc=|pmid=31445522|access-date=|quote=|via=}}</ref> - [https://link.springer.com/article/10.1186/s12883-019-1433-0#citeas (Full text)] * 2019, [[Low dose naltrexone|Naltrexone]] restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients<ref>{{Cite journal | last = Cabanas | first = Helene | authorlink = Hélène Cabanas | last2 = Muraki | first2 = Katsuhiko | authorlink2 = | last3 = Staines | first3 = Donald | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya | authorlink4 = Sonya Marshall-Gradisnik | date = 14 Oct 2019 | title = Naltrexone restores impaired transient receptor potential melastatin 3 ion channel function in natural killer cells from myalgic encephalomyelitis/chronic fatigue syndrome patients |url =https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/abstract|journal=Frontiers in Immunology|volume=|issue= | pages = |doi=10.3389/fimmu.2019.02545|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/abstract (Abstract)] * 2019, Intra [[brainstem]] connectivity is impaired in chronic fatigue syndrome<ref>{{Cite journal | last = Barnden | first = Leighton R | authorlink = Leighton Barnden | last2 = Shan | first2 = Zack Y | authorlink2 = Zack Shan | last3 = Staines | first3 = Donald R | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya | authorlink4 = Sonya Marshall-Gradisnik | last5 = Finegan | first5 = Kevin | authorlink5 = | last6 = Ireland | first6 = Timothy | author-link6 = | last7 = Bhuta | first7 = Sandeep | date = 2019 | title=Intra brainstem connectivity is impaired in chronic fatigue syndrome | url =https://linkinghub.elsevier.com/retrieve/pii/S2213158219303924|journal=NeuroImage: Clinical|language=en|volume=24|issue= | pages = 102045|doi=10.1016/j.nicl.2019.102045|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.sciencedirect.com/science/article/pii/S2213158219303924 (Full text)] * 2019, [[Transient receptor potential melastatin 2]] channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients<ref name="Balinas2019">{{Cite journal | last = Balinas | first = Cassandra | authorlink = Cassandra Balinas | last2 = Cabanas | first2 = Hélène | authorlink2 = Hélène Cabanas | last3 = Staines | first3 = Donald | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya | authorlink4 = Sonya Marshall-Gradisnik | date = 2019-12-03 | title = Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients |url =https://doi.org/10.1186/s12967-019-02155-4|journal=Journal of Translational Medicine|volume=17|issue=1 | pages = 401|doi=10.1186/s12967-019-02155-4|issn=1479-5876|pmc = 6891975|pmid=31796045|access-date=|quote=|via=}}</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-019-02155-4 (Full text)] * 2020, Health-related quality of life in patients with myalgic encephalomyelitis/chronic fatigue syndrome: an Australian cross-sectional study<ref>{{Cite journal | last = Eaton-Fitch | first = N. | authorlink = Natalie Eaton-Fitch | last2 = Johnston | first2 = S. C. | authorlink2 = Samantha Johnston | last3 = Zalewski | first3 = P. | authorlink3 = | last4 = Staines | first4 =D. | authorlink4 = Donald Staines | last5 = Marshall-Gradisnik | first5 = S. | authorlink5 = Sonya Marshall-Gradisnik | date = 2020-01-22 | title = Health-related quality of life in patients with myalgic encephalomyelitis/chronic fatigue syndrome: an Australian cross-sectional study | url = http://link.springer.com/10.1007/s11136-019-02411-6|journal=Quality of Life Research|language=en|volume=|issue= | pages = |doi=10.1007/s11136-019-02411-6|issn=0962-9343|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://link.springer.com/article/10.1007%2Fs11136-019-02411-6 (Full text)] * 2020, Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans<ref>{{Cite journal | last = Thapaliya | first = Kiran | authorlink = | last2 = Marshall-Gradisnik | first2 = Sonya | authorlink2 = Sonya Marshall-Gradisnik | last3 = Staines | first3 = Don | authorlink3 = Donald Staines | last4 = Barnden | first4 = Leighton | authorlink4 = Leighton Barnden | date = 2020 | title=Mapping of pathological change in chronic fatigue syndrome using the ratio of T1- and T2-weighted MRI scans |url =https://linkinghub.elsevier.com/retrieve/pii/S2213158220302035|journal=NeuroImage: Clinical|language=en|volume=28|issue= | pages = 102366|doi=10.1016/j.nicl.2020.102366|pmc = 7417892|pmid=32777701|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417892/ (Full text)] *2021, Systematic Review of Sleep Characteristics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="Maksoud2021">{{Cite journal | last = Maksoud | first = Rebekah | authorlink = | last2 = Eaton-Fitch | first2 = Natalie | authorlink2 = Natalie Eaton-Fitch | last3 = Matula | first3 = Michael | authorlink3 = | last4 = Cabanas | first4 = Hélène | authorlink4 = Hélène Cabanas | last5 = Staines | first5 = Donald | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | author-link6 = Sonya Marshall-Gradisnik | date = May 2021 | title = Systematic Review of Sleep Characteristics in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | url =https://www.mdpi.com/2227-9032/9/5/568|journal=Healthcare|language=en|volume=9|issue=5 | pages = 568|doi=10.3390/healthcare9050568|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.mdpi.com/2227-9032/9/5/568/htm (Full text)] *2021, Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment<ref name="Cabanas2021">{{Cite journal | title = Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment | date = 2021 | url = https://www.frontiersin.org/articles/10.3389/fimmu.2021.687806|journal=Frontiers in Immunology|volume=12|issue= | pages = 687806 | last = Cabanas | first = Helene | authorlink = Hélène Cabanas | last2 = Muraki | first2 = Katsuhiko | authorlink2 = | last3 = Eaton-Fitch | first3 = Natalie | authorlink3 = Natalie Eaton-Fitch | last4 = Staines | first4 = Donald Ross | authorlink4 = Donald Staines | last5 = Marshall-Gradisnik | first5 = Sonya | authorlink5 = Sonya Marshall-Gradisnik|doi=10.3389/fimmu.2021.687806|pmc=PMC8313851|pmid=34326841|access-date=|issn=1664-3224|quote=|via=}}</ref> - [https://www.frontiersin.org/articles/10.3389/fimmu.2021.687806/full (Full text)]
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