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Epidemiology of myalgic encephalomyelitis and chronic fatigue syndrome
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==Incidence and Prevalence== The prevalence rate is projected at 0.2%<ref name="Nacul2011" /><ref name="Reyes2003" />-0.4%<ref name="Jason, 1999" /><ref>{{Cite news |url =https://mecfsresearchreview.me/2018/06/11/analysis-of-data-from-500000-individuals-in-uk-biobank-demonstrates-an-inherited-component-to-me-cfs/ | title = Analysis of data from 500,000 individuals in UK Biobank demonstrates an inherited component to ME/CFS | date = 2018-06-11|work=ME/CFS Research Review|access-date=2018-08-11|language=en-US}}</ref> although estimates vary widely due to different definitions and sampling methods used.<ref>{{Cite journal | last = Johnston | first = Samantha | authorlink = Samantha Johnston | last2 = Brenu | first2 = Ekua W. | authorlink2=Ekua Brenu | last3 = Staines | first3 = Donald | authorlink3 = Donald Staines | last4 = Marshall-Gradisnik | first4 = Sonya | authorlink4 = Sonya Marshall-Gradisnik| date = 2013 | title = The prevalence of chronic fatigue syndrome/ myalgic encephalomyelitis: a meta-analysis |url =https://www.ncbi.nlm.nih.gov/pubmed/23576883|journal=Clinical Epidemiology|volume=5 | pages = 105β110|doi=10.2147/CLEP.S39876|issn=1179-1349|pmc=3616604|pmid=23576883}}</ref> Estimated incidence rates β generally, the number of new cases in a single year β vary from 0.025%<ref name="bakken2014" /> to 0.3% of the population. === Incidence and prevalence by country === {| class="wikitable" !Country !Incidence !Prevalence rate !Total number |- |Australia | | |242,000 people have CFS (of which 94,000 meet a narrower definition for ME).<ref>''Emerge Quarterly Journal'', AUTUMN 2016 - Vol 36 - No 1, page 14, Mar 2016</ref> |- |United Kingdom |0.015%<ref name="Nacul2011">{{Cite journal | last = Nacul | first = LC | date = July 2011 | title = Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care | url =https://www.ncbi.nlm.nih.gov/pubmed/21794183|journal=BMC Medicine|volume=9 | pages = 91|via=}}</ref> |0.03-0.19%<ref name="Nacul2011" /> |250,000<ref>{{Cite web | last = Working Group on CFS/ME | first = Department of Health | date = 2003-01-11 | title = Annex 1: Epidemiology of CFS/ME| url = https://webarchive.nationalarchives.gov.uk/20120106043826/http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/Browsable/DH_4879305}}</ref> |- |United States | | |836,000 to 2.5 million<ref name="SEID-IOM2015" /><ref name="Key" /> |- |The Netherlands | |0.11%<ref>Bazelmans E, Vercoulen J.H.M.M, Galama J.M.D, Van Weel, C, Van Der Meer J.W.M, Bleijenberg G. (1997). [https://www.ntvg.nl/system/files/publications/1997115200001a.pdf Prevalentie van het chronische-vermoeidheidssyndroom en het primaire-fibromyalgiesyndroom in Nederland.] Nederlands Tijdschrift voor Geneeskunde; 141: 1520-1523.Β </ref><ref>Versluis R.G.J.A, De Waal M.W.M, Opmeer C, Petri H, Springer M.P. (1997). [https://www.ntvg.nl/system/files/publications/1997115230001a.pdf Prevalentie van het chronische-vermoeidheidssyndroom in 4 huisartspraktijken in de regio Leiden.] Nederlands Tijdschrift voor Geneeskunde; 141(31): 1523-26.Β </ref> |30.000-40.000<ref>Health Council of the Netherlands. ME/CFS. The Hague: Health Council of the Netherlands, 2018; publication no. 2018/07.</ref> |} === Incidence and prevalence by definition === {| class="wikitable" !Method !12-month incidence !Prevalence rate |- |[[Postviral fatigue syndrome]] ([[ICD-10-CM]] G93.3 in a national health registry in Norway) |0.025%<ref>{{Cite journal | last = Magnus | first = P | date = November 17, 2015 | title = Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with pandemic influenza infection, but not with an adjuvanted pandemic influenza vaccine | url =https://www.ncbi.nlm.nih.gov/pubmed/26475444|journal=Vaccine|volume=33 | pages = 6173-7|via=}}</ref> (NO) |β |- |[[Fukuda criteria|Fukuda Criteria (CDC-1994 definition]]) | |0.19%<ref name="Nacul2011" /> (UK), 0.24%<ref name="Reyes2003">{{Cite journal | last = Reyes | first = Michele | date = July 14, 2003 | title = Prevalence and Incidence of Chronic Fatigue Syndrome in Wichita, Kansas |url =https://www.ncbi.nlm.nih.gov/pubmed/12860574|journal=JAMA Internal Medicine|volume=163 | pages = 1530-1536|via=}}</ref> (US. Kansas), 0.42%<ref name="Jason, 1999" /> (US, Chicago), |- |[[Canadian Consensus Criteria]] (CCC) | |0.11%<ref name="Nacul2011" /> (UK) |- |Empirical definition ([[Reeves criteria]]) | |2.54%<ref>{{Cite journal | last = Reeves | first = William C. | last2 = Jones | first2 = James F. | last3 = Maloney | first3 = Elizabeth | last4 = Heim | first4 = Christine | last5 = Hoaglin | first5 = David C. | last6 = Boneva | first6 = Roumiana S. | last7 = Morrissey | first7 = Marjorie | last8 = Devlin | first8 = Rebecca | date = 2007-06-08 | title = Prevalence of chronic fatigue syndrome in metropolitan, urban, and rural Georgia| url = https://www.ncbi.nlm.nih.gov/pubmed/17559660|journal=Population Health Metrics|volume=5 | pages = 5|doi=10.1186/1478-7954-5-5|issn=1478-7954|pmc=1904178|pmid=17559660}}</ref> |- |[[Epidemiological Case Definition]] (ECD) |0.015%<ref name="Nacul2011" /> (UK) |0.03%<ref name="Nacul2011" /> (UK) |- |Diagnoses reported by general practitioners and pediatricians in the Netherlands (criteria unspecified) |0.012%<ref name="Nijhof2011">{{Cite journal | last = Nijhof | first = Sanne | authorlink = Sanne Nijhof | date = April 2011 | title = Adolescent Chronic Fatigue Syndrome: Prevalence, Incidence, and Morbidity| url = http://pediatrics.aappublications.org/content/early/2011/04/18/peds.2010-1147|journal=Pediatrics|volume= | pages = |via=}}</ref> (NL, 10-18 year olds) |0.11%<ref name="Nijhof2011" /> (NL, 10-18 year olds) |}
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