Excessive irritability: Difference between revisions
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==Prevalence== | ==Prevalence== | ||
*Katrina Berne reports a prevalence of 70-90% for mood swings, excessive irritability, and overreaction.<ref>{{ | *Katrina Berne reports a prevalence of 70-90% for mood swings, excessive irritability, and overreaction in people with [[chronic fatigue syndrome]].<ref>{{cite book|last= Berne|first= Katrina |date=Dec 1, 1995|author-link=Katrina Berne|title= Running on Empty: The Complete Guide to Chronic Fatigue Syndrome (CFIDS)|edition=2nd|url= https://www.amazon.co.uk/Running-Empty-Complete-Chronic-Syndrome/dp/0897931912/ |publisher= Hunter House|page= 60 |isbn= 978-0897931915}}</ref> | ||
==Symptom recognition== | ==Symptom recognition== | ||
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==Potential treatments== | ==Potential treatments== | ||
Severe irritability is a common symptom in autism, and the main treatment for this is atypical anti-psychotic drugs such as amisulpride ( | Severe irritability is a common symptom in autism, and the main treatment for this is atypical [[:Category:antipsychotics|anti-psychotic]] drugs such as [[amisulpride]] (Solian), [[risperidone]] (Risperdal) or [[aripiprazole]] (Abilify).<ref>{{Cite journal|last=Posey|first=David J.|last2=Stigler|first2=Kimberly A.|last3=Erickson|first3=Craig A.|last4=McDougle|first4=Christopher J.|date=2008-01-02|title=Antipsychotics in the treatment of autism|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171144/|journal=The Journal of Clinical Investigation|volume=118|issue=1|pages=6–14|doi=10.1172/JCI32483|issn=0021-9738|pmc=2171144|pmid=18172517}}</ref> Very low dose amisulpride has also been shown to reduce the [[fatigue]] and bodily symptoms of ME/CFS<ref>{{Cite journal|last=Pardini|first=Matteo|last2=Guida|first2=Silvia|last3=Primavera|first3=Alberto|last4=Krueger|first4=Frank|last5=Cocito|first5=Leonardo|last6=Gialloreti|first6=Leonardo Emberti|date=Mar 2011|title=Amisulpride vs. fluoxetine treatment of chronic fatigue syndrome: a pilot study|url=https://www.ncbi.nlm.nih.gov/pubmed/21112746|journal=European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology|volume=21|issue=3|pages=282–286|doi=10.1016/j.euroneuro.2010.10.008|issn=1873-7862|pmid=21112746}}</ref>. [[N-acetyl-cysteine]] can help the irritability in autism, but the research showed this is not quite as effective as atypical anti-psychotics.<ref>{{Cite journal|last=Hardan|first=Antonio Y.|last2=Fung|first2=Lawrence K.|last3=Libove|first3=Robin A.|last4=Obukhanych|first4=Tetyana V.|last5=Nair|first5=Surekha|last6=Herzenberg|first6=Leonore A.|last7=Frazier|first7=Thomas W.|last8=Tirouvanziam|first8=Rabindra|date=Jun 2012|title=A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism|url=http://linkinghub.elsevier.com/retrieve/pii/S0006322312000534|journal=Biological Psychiatry|volume=71|issue=11|pages=956–961|doi=10.1016/j.biopsych.2012.01.014|issn=0006-3223|pmc=4914359|pmid=22342106}}</ref> | ||
==Learn more== | ==Learn more== | ||
Revision as of 14:54, April 7, 2020
Presentation[edit | edit source]
Prevalence[edit | edit source]
- Katrina Berne reports a prevalence of 70-90% for mood swings, excessive irritability, and overreaction in people with chronic fatigue syndrome.[1]
Symptom recognition[edit | edit source]
- In the Holmes criteria, excessive irritability is an optional criteria for diagnosis, under the section Minor Symptom Criteria - Neuropsychologic Complaints.[2]
Notable studies[edit | edit source]
Possible causes[edit | edit source]
Potential treatments[edit | edit source]
Severe irritability is a common symptom in autism, and the main treatment for this is atypical anti-psychotic drugs such as amisulpride (Solian), risperidone (Risperdal) or aripiprazole (Abilify).[3] Very low dose amisulpride has also been shown to reduce the fatigue and bodily symptoms of ME/CFS[4]. N-acetyl-cysteine can help the irritability in autism, but the research showed this is not quite as effective as atypical anti-psychotics.[5]
Learn more[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- ↑ Berne, Katrina (December 1, 1995). Running on Empty: The Complete Guide to Chronic Fatigue Syndrome (CFIDS) (2nd ed.). Hunter House. p. 60. ISBN 978-0897931915.
- ↑ The 1988 Holmes Definition for CFS
- ↑ Posey, David J.; Stigler, Kimberly A.; Erickson, Craig A.; McDougle, Christopher J. (January 2, 2008). "Antipsychotics in the treatment of autism". The Journal of Clinical Investigation. 118 (1): 6–14. doi:10.1172/JCI32483. ISSN 0021-9738. PMC 2171144. PMID 18172517.
- ↑ Pardini, Matteo; Guida, Silvia; Primavera, Alberto; Krueger, Frank; Cocito, Leonardo; Gialloreti, Leonardo Emberti (March 2011). "Amisulpride vs. fluoxetine treatment of chronic fatigue syndrome: a pilot study". European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology. 21 (3): 282–286. doi:10.1016/j.euroneuro.2010.10.008. ISSN 1873-7862. PMID 21112746.
- ↑ Hardan, Antonio Y.; Fung, Lawrence K.; Libove, Robin A.; Obukhanych, Tetyana V.; Nair, Surekha; Herzenberg, Leonore A.; Frazier, Thomas W.; Tirouvanziam, Rabindra (June 2012). "A Randomized Controlled Pilot Trial of Oral N-Acetylcysteine in Children with Autism". Biological Psychiatry. 71 (11): 956–961. doi:10.1016/j.biopsych.2012.01.014. ISSN 0006-3223. PMC 4914359. PMID 22342106.
