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'''Fibromyalgia drugs''' include prescription drugs currently approved or used off-label for [[Fibromyalgia]] (FM/FMS), and experimental drugs under investigation. There are currently three FDA approved drugs for fibromyalgia: * [[Cymbalta]] (duloxetine) * [[Lyrica]] (pregabalin), and * [[Savella]] (milnapracin)<ref name="af">{{Cite web | url = https://www.arthritis.org/diseases/more-about/medications-for-treating-fibromyalgia-symptoms | last = | first = | title = Medications for Treating Fibromyalgia Symptoms | website = Arthritis Foundation | date = 2022-10-13 }}</ref> === FDA approved=== {| class="wikitable" |+Fibromyalgia Drugs - FDA Approved !Brand Name Drug Overview !Generic Drug Overview !Side Effects and Interactions !More on Side Effects and Interactions ''Not all side effects or possible drug interactions of brand name or generic name drugs are listed or linked in this chart.'' |- |[[Cymbalta]]<ref>{{Cite news |url =https://www.drugs.com/cymbalta.html | title = Cymbalta Uses, Dosage, Side Effects & Warnings - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> |Duloxetine<ref name="duloxetine-drugs">{{Cite news |url =https://www.drugs.com/duloxetine.html | title = Duloxetine: Uses, Side Effects, Dosage, Warnings - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> |Cymbalta<ref name="dulox-sfx">{{Cite news |url =https://www.drugs.com/sfx/cymbalta-side-effects.html | title = Cymbalta Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref name="dulox-int">{{Cite news |url =https://www.drugs.com/drug-interactions/duloxetine,cymbalta.html | title = Cymbalta Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> Duloxetine<ref>{{Cite news |url =https://www.drugs.com/sfx/duloxetine-side-effects.html | title = Duloxetine Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/duloxetine.html | title = Duloxetine Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | * Cymbalta is facing lawsuits due to severe withdrawal symptoms.<ref>{{Cite news |url =https://www.drugwatch.com/cymbalta/lawsuits/ | title = Cymbalta Lawsuit - Settlements, Withdrawal & Suicide Claims | last = Miller | first = Emily | date = |work=Drugwatch.com|access-date=2018-08-21|archive-url=|archive-date=|url-status=|language=en-US}}</ref> Eli Lilly has settled hundreds of personal injury lawsuits with patients experiencing severe withdrawal symptoms.{{citation needed}} |- |[[Lyrica]] | Pregabalin (2019)<ref>{{Cite web | url = https://www.healthcentral.com/article/court-blocks-sale-of-generic-lyrica-upholds-pfizer-patents | title = Court Blocks Sale of Generic Lyrica, Upholds Pfizer Patents - Non-opioid Pain Medication - Chronic Pain| website = HealthCentral|language=en-US|access-date=2018-08-21}}</ref> |Lyrica<ref>{{Cite news |url =https://www.drugs.com/sfx/lyrica-side-effects.html | title = Lyrica Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/pregabalin,lyrica.html | title = Lyrica Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | * Severe weight gain |- |[[Savella]]<ref>{{Cite news |url =https://www.drugs.com/savella.html | title = Savella (milnacipran) Uses, Dosage, Side Effects - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | Milnacipran<ref>{{Cite news |url =https://www.drugs.com/drug-interactions/milnacipran.html | title = Milnacipran Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | Savella<ref>{{Cite news |url =https://www.drugs.com/sfx/savella-side-effects.html | title = Savella Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/milnacipran,savella.html | title = Savella Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> Milnacapiran<ref>{{Cite news |url =https://www.drugs.com/sfx/milnacipran-side-effects.html | title = Milnacipran Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/milnacipran.html | title = Milnacipran Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | |} ===Off-label=== {| class="wikitable" |+Off-label Drugs Used For Fibromyalgia !Brand Name Drug Overview !Generic Drug Overview !Off-label Use !Side Effects and Interactions !More on Side Effects and Interactions ''Not all side effects or possible drug interactions of brand name or generic name drugs are listed or linked in this chart.'' ''Brands and their generics can have different side effects and interactions.'' ''Review EACH brand name and EACH generic name medication's side effects and possible drug interactions with your doctor and pharmacist.'' |- | [[Florinef]]<ref>{{Cite news |url =https://www.drugs.com/dosage/florinef.html | title = Florinef Dosage Guide - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> |Fludrocortisone |[[Orthostatic intolerance]] and [[Postural orthostatic tachycardia syndrome|POTS]] | Florinef<ref>{{Cite news |url =https://www.drugs.com/sfx/florinef-side-effects.html | title = Florinef Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/fludrocortisone,florinef.html | title = Florinef Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> Fludrocortisone<ref>{{Cite news |url =https://www.drugs.com/sfx/fludrocortisone-side-effects.html | title = Fludrocortisone Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/fludrocortisone.html | title = Fludrocortisone Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | * [[Weight gain]] * Interacts with many other medications |- |[[Neurontin]] |Gabapentin |[[Pain]], [[Sleep dysfunction|sleep]] | Neurontin<ref>{{Cite news |url =https://www.drugs.com/sfx/neurontin-side-effects.html | title = Neurontin Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/gabapentin,neurontin.html | title = Neurontin Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> Gabapentin<ref>{{Cite news |url =https://www.drugs.com/sfx/gabapentin-side-effects.html | title = Gabapentin Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/gabapentin.html | title = Gabapentin Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | * Weight gain |- | [[mirtazapine|Remeron]]<ref>{{Cite news |url =https://www.drugs.com/remeron.html | title = Remeron: Side Effects, Dosage & Uses - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> |Mirtazapine |Chronic [[insomnia]] | Remeron<ref>{{Cite news |url =https://www.drugs.com/sfx/remeron-side-effects.html | title = Remeron Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/mirtazapine,remeron.html | title = Remeron Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> Mirtazapine<ref>{{Cite news |url =https://www.drugs.com/sfx/mirtazapine-side-effects.html | title = Mirtazapine Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/mirtazapine.html | title = Mirtazapine Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | * Severe [[weight gain]] * [[Skin itch|Intense itching]] |- |[[Low-dose nalrexone|ReVia, Vivitrol]]<ref>{{Cite news |url =https://www.drugs.com/mtm/revia.html | title = ReVia Uses, Side Effects & Warnings - Drugs.com|work=Drugs.com|access-date=2018-09-04|language=en-US}}</ref> |Low-dose naltrexone (LDN) |Pain, [[depression|positive mood]], sleep quality, and [[fatigue]]<ref>{{Cite journal | last = Younger | first = Jarred | authorlink = Jarred Younger | last2 = Noor | first2 = Noorulain | last3 = McCue | first3 = Rebecca | last4 = Mackey | first4 = Sean | date = 2013-01-28 | title = Low-dose naltrexone for the treatment of fibromyalgia: Findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels |url =https://onlinelibrary.wiley.com/doi/full/10.1002/art.37734|journal=Arthritis & Rheumatism|language=en|volume=65|issue=2 | pages = 529β538|doi=10.1002/art.37734|issn=0004-3591}}</ref><ref>{{Cite web | url = https://med.stanford.edu/pain/snapl/completed-research/naltrexone2.html | title = Low Dose Naltrexone for Fibromyalgia|website=Stanford Medicine {{!}} Systems Neuroscience and Pain Lab|language=en|access-date=2018-10-04}}</ref> | [[Revia]]<ref>{{Cite news |url =https://www.drugs.com/sfx/revia-side-effects.html | title = Revia Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/naltrexone,revia.html | title = Revia Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> [[Low dose naltrexone]] (LDN)<ref>{{Cite news |url =https://www.drugs.com/sfx/naltrexone-side-effects.html | title = Naltrexone Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/naltrexone.html | title = Naltrexone Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | * Must be stepped up slowly * [[Opioid]]s will be rendered ineffective |- | [[Seroquel]] (low dose)<ref>{{Cite news |url =https://www.drugs.com/seroquel.html | title = Seroquel: Drug Uses, Dosage & Side Effects - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | Quetiapine (low dose)<ref name="quetiapine">{{Cite news |url =https://www.drugs.com/mtm/quetiapine.html | title = Quetiapine Uses, Side Effects & Warnings - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> |Chronic [[insomnia]] | Seroquel<ref>{{Cite news |url =https://www.drugs.com/sfx/seroquel-side-effects.html | title = Seroquel Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/quetiapine,seroquel.html | title = Seroquel Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> Quetiapine (low dose)<ref>{{Cite news |url =https://www.drugs.com/sfx/quetiapine-side-effects.html | title = Quetiapine Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/quetiapine.html | title = Quetiapine Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | * Severe [[weight gain]] * increased risk of [[Suicide|Suicidal ideation or actions]] in children and young people under 25<ref name="quetiapine" /> * Although prescribed for [[insomnia]] it is not recommended for this off-label use.<ref>{{Cite journal | last = Coe | first = Holly V | last2 = Hong | first2 = Irene S | date = 2012-04-17 | title = Safety of Low Doses of Quetiapine When Used for Insomnia| url = http://journals.sagepub.com/doi/10.1345/aph.1Q697|journal=Annals of Pharmacotherapy|language=en|volume=46|issue=5 | pages = 718β722|doi=10.1345/aph.1q697|issn=1060-0280}}</ref><ref>{{Cite book | url = http://www.ncbi.nlm.nih.gov/books/NBK66081/ | title = Off-Label Use of Atypical Antipsychotics: An Update | last = Maglione | first = Margaret | last2 = Maher | first2 = Alicia Ruelaz | last3 = Hu | first3 = Jianhui | last4 = Wang | first4 = Zhen | last5 = Shanman | first5 = Roberta | last6 = Shekelle | first6 = Paul G. | last7 = Roth | first7 = Beth | last8 = Hilton | first8 = Lara | last9 = Suttorp | first9 = Marika J.| date = 2011 | publisher = Agency for Healthcare Research and Quality (US)|series=AHRQ Comparative Effectiveness Reviews|location=Rockville (MD)|pmid=22132426}}</ref> |- | [[Ultram, ConZip, Qdolo]]<ref>{{Cite news |url =https://www.drugs.com/ultram.html | title = Ultram Uses, Dosage & Side Effects - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> |Tramadol |[[Pain]] | Ultram<ref>{{Cite news |url =https://www.drugs.com/sfx/ultram-side-effects.html | title = Ultram Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/tramadol,ultram.html | title = Ultram Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> Tramadol<ref>{{Cite news |url =https://www.drugs.com/sfx/tramadol-side-effects.html | title = Tramadol Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/tramadol.html | title = Tramadol Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | * Tramadol induced seizure: A 3-year study<ref name=":0">{{Cite journal | last = Boostani | first = Reza | last2 = Derakhshan | first2 = Siavash| date = 2012 | title = Tramadol induced seizure: A 3-year study| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755854/|journal=Caspian Journal of Internal Medicine|volume=3|issue=3 | pages = 484β487|issn=2008-6164|pmc=3755854|pmid=24009919}}</ref> *Seizures{{citation needed}} |- | [[Zanaflex]]<ref>{{Cite news |url =https://www.drugs.com/zanaflex.html | title = Zanaflex: Uses, Dosage & Side Effects - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | [[Tizanadine]]<ref>{{Cite news |url =https://www.drugs.com/tizanidine.html | title = Tizanidine Uses, Dosage, Side Effects - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> |Chronic [[insomnia]] | Zanaflex<ref>{{Cite news |url =https://www.drugs.com/sfx/zanaflex-side-effects.html | title = Zanaflex Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/tizanidine,zanaflex.html | title = Zanaflex Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> Tizanidine<ref>{{Cite news |url =https://www.drugs.com/sfx/tizanidine-side-effects.html | title = Tizanidine Side Effects in Detail - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref><ref>{{Cite news |url =https://www.drugs.com/drug-interactions/tizanidine.html | title = Tizanidine Drug Interactions - Drugs.com|work=Drugs.com|access-date=2018-08-21|language=en-US}}</ref> | |} ===Sleep medications=== ''Brands and their generics can have different side effects and interactions. Review EACH brand name and EACH generic name medication's side effects and possible drug interactions with your doctor and pharmacist.'' [[Sleep dysfunction]] is a prominent symptom in FM. There are several types of sleep medications used for FM; antihistamines, benzodiazepines, nonbenzodiazepines, sedating antidepressants and sedating antipsychotics.<ref name="QAbook">{{Cite book | title = 100 Questions & Answers About Fibromyalgia | date = 2009-05-05|publisher=Jones & Bartlett Publishers|isbn=978-0-7637-8708-0|language=en| url = https://books.google.co.uk/books?id=dA4kQulQ2ZMC&lpg=PT80&dq=fibromyalgia%25&f=false | last = Ostalecki | first = Sharon | last2 = Tamler | first2 = Martin S.}}</ref> === Drug trials === *ASP8062 :*2017, A Phase 2a, Randomized, Double-Blind Placebo-controlled, Parallel-group Study to Assess the Analgesic Efficacy and Safety of ASP8062 in Subjects With Fibromyalgia<ref>{{Cite news |url =https://clinicaltrials.gov/ct2/show/NCT03092726?term=ASP8062&cond=Fibromyalgia&rank=1 | title = A Study to Assess the Analgesic Efficacy and Safety of ASP8062 in Subjects With Fibromyalgia - ClinicalTrials.gov|access-date=2018-08-09|language=en}}</ref> *[[Cannabinoid|Cannabinoid-based]] therapy :*2017, Intec Pharma Launches Phase 1 Trial of Cannabinoid-based Therapy for Fibromyalgia, Lower Back Pain.{{citation needed}}<ref>{{Cite news |url =https://fibromyalgianewstoday.com/2017/03/27/fibromyalgia-targeted-ap-cbd-thc-therapy-undergoing-phase-1-clinical-trial/ | title = Intec Pharma Launches Phase 1 Trial of Cannabinoid-based Therapy for Fibromyalgia, Lower Back Pain | last = Henriques | first = Carolina | date = Mar 27, 2017|work=Fibromyalgia News Today|access-date=Aug 9, 2017|archive-url=|archive-date=|url-status=}}</ref> *[[IMC-1]] :*2016, The Pridgen Revolution? Dr. Pridgen on Bringing His Antiviral Approach to Fibromyalgia To Market <ref name=":11" /> :<blockquote>Almost three years ago, Dr. Pridgen threatened to turn the world of fibromyalgia treatment on its head. Few had connected fibromyalgia with viruses or even immune problems when Pridgen announced that a) FM is caused herpes simplex virus reactivation and b) that it could be treated with antivirals.<ref name=":11">{{Cite news |url =http://simmaronresearch.com/2016/10/pridgen-antiviral-treatment-fibromyaligia/ | title = The Pridgen Revolution? Dr. Pridgen on Bringing His Antiviral Approach to Fibromyalgia To Market - Simmaron Research | last = Johnson | first = Cort | date = 2016-10-17|work=Simmaron Research|access-date=2018-08-09|archive-url=|archive-date=|url-status=|language=en-US}}</ref></blockquote> :*2016, Novel Fibromyalgia Treatment Granted FDA Fast Track Designation{{citation needed}}<ref name=":12" /> :<blockquote>In the successful Phase II trial in fibromyalgia, IMC-1 was studied to confirm the hypothesis that chronic tissue-resident herpes simplex virus type 1 ([[Herpes simplex virus#HSV-1|HSV-1]]) may be one of the underlying causes of fibromyalgia and causally related to fibromyalgia symptoms or recurrence. IMC-1 is a novel fixed-dose oral combination antiviral medication designed to suppress this suspected virus and thus alleviate fibromyalgia symptoms.{{citation needed}}<ref name=":12">{{Cite news |url =http://fibromyalgianewstoday.com/2016/02/02/combo-tx-fast-tracked-for-fibromyalgia/ | title = Novel Fibromyalgia Treatment Granted FDA Fast Track Designation - Fibromyalgia News Today | last = Moore | first = Charles | date = 2016-02-02|work=Fibromyalgia News Today|access-date=2018-08-09|archive-url=|archive-date=|url-status=|language=en-US}}</ref></blockquote> :*2017, Through the βValley of Deathβ: Dr. Pridgen, Fibromyalgia and the Looming Trials<ref name=":13" /> :<blockquote>First there were the anecdotal reports β FM patients were not just getting better but some, and not just a few, were getting well using something entirely new β an antiviral protocol, of all things, created not by a pain specialist or rheumatologist but by a surgeon.<ref name=":13">{{Cite news |url =http://simmaronresearch.com/2017/03/valley-death-fibromyalgia-pridgen/ | title = Through the "Valley of Death": Dr. Pridgen, Fibromyalgia and the Looming Trials - Simmaron Research | last = Johnson | first = Cort | date = 2017-03-26 | work=Simmaron Research|access-date=2018-08-09|archive-url=|archive-date=|url-status=|language=en-US}}</ref></blockquote> :*2017, A famciclovir + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia<ref name=":24">{{Cite journal | last = Pridgen | first = William L | last2 = Duffy | first2 = Carol | last3 = Gendreau | first3 = Judy F | last4 = Gendreau | first4 = R Michael | date = 2017-02-22 | title = A famciclovir + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia| url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328426/|journal=Journal of Pain Research|volume=10 | pages = 451β460|doi=10.2147/JPR.S127288|issn=1178-7090|pmc=|pmid=28260944|via=}}</ref> :<blockquote>IMC-1 was efficacious and safe in treating symptoms of fibromyalgia, supporting the hypothesis that herpes virus infections may contribute to this syndrome. Improved retention rates, decreased adverse event rates, and evidence of efficacy on a broad spectrum of outcome measures are suggestive that IMC-1 may represent an effective, novel treatment for fibromyalgia.<ref name=":24" /></blockquote> ===Drug trials failed and drugs abandoned=== *TNX-102 :*2016, The drug failed in its primary goal in providing pain relief and ''Tonix Pharmaceuticals'' will not be moving forward in developing a Ffbromyalgia drug.{{citation needed}}<ref>{{Cite news |url =http://nationalpainreport.com/potential-fibromyalgia-treatment-is-put-on-hold-8831410.html | title = Potential Fibromyalgia Treatment is Put on Hold | last = Gregory Burch | first = Donna | date = 2016-09-10|work=National Pain Report|access-date=2018-08-09|archive-url=|archive-date=|url-status=|language=en-US}}</ref> *Phase III clinical trial of DS-5565 found ineffective :*2017, The Big Hurt: Second Major Fibromyalgia Drug in a Year Fails<ref name=":14" /> :<blockquote>In the three 13-week, double-blind, global, phase 3 ALDAY clinical trials evaluating Mirogabalin for the treatment of pain associated with fibromyalgia, Mirogabalin did not meet the primary efficacy endpoint to demonstrate a statistically significant reduction in the weekly average of worst daily pain score from baseline to Week 13.<ref name=":14">{{Cite news |url =https://www.healthrising.org/blog/2017/07/08/mirogabalin-fibromyalgia-drug-fails/ | title = The Big Hurt: Second Major Fibromyalgia Drug in a Year Fails - Health Rising | last = Johnson | first = Cort | date = 2017-07-08|work=Health Rising|access-date=2018-08-09|archive-url=|archive-date=|url-status=|language=en-US}}</ref></blockquote> *[[BCG vaccination|BCG vaccine]], the planned clinical trial was withdrawn in 2022<ref name="NCT03582085">{{Cite web | title = Phase II Clinical Trial: Multi-dosing the BCG Vaccine for Fibromyalgia | date = 2022-04-05 | url = https://clinicaltrials.gov/ct2/show/NCT03582085|website=Clinical Trials|last=Faustman | first = Denise Louise | author-link = Denise Faustman | last2 = Massachusetts General Hospital|access-date=2023-03-04|quote=|via=}}</ref> :*2017, Century-old vaccine gives new hope to fibromyalgia community<ref>{{Cite news |url =https://www.prohealth.com/library/century-old-vaccine-gives-new-hope-to-fibromyalgia-community-42689 | title = Century-old Vaccine Gives New Hope to Fibromyalgia Community - Prohealth | last = Gregory Burch | first = Donna | date = 2017-08-14|work=Prohealth|access-date=2018-08-09|archive-url=http://web.archive.org/web/20200811013738/https://www.prohealth.com/library/century-old-vaccine-gives-new-hope-to-fibromyalgia-community-42689|archive-date=2020-07-10|url-status=|language=en-US}}</ref> :*2018, FDA gives approval for clinical trial. == See also == * [[Fibromyalgia]] * [[:Category:Drug-free pain management|Drug-free pain management (category)]] * [[Fibromyalgia disability process]] * [[Fibromyalgia notable studies]] == Learn more == *[https://fibromapp.com/having-seizures-or-blackouts-the-tramadol-connection/ Having Seizures or Blackouts? The Tramadol Connection] *[https://www.verywellhealth.com/how-lyrica-changes-the-fibromyalgia-brain-715767 How Lyrica Changes the Fibromyalgia Brain] *[http://fedupwithfatigue.com/why-your-fibro-meds-arent-working/ Why Your Fibro Meds Aren't Working] == References == {{reflist}} [[Category:Potential treatments]] [[Category:Analgesics]]
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