Fucosyltransferase 2 enzyme
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Fucosyltransferase 2 enzyme (FUT2) is an enzyme that adds fucose to N-glycans. Fucose N-glycans protect against intestinal dysbiosis and sepsis.[1] 20-30% of humans carry nonsense mutations of FUT2 and are "non-secretors."[2]
Microbiome[edit | edit source]
Genetic non-secretors of FUT2 and those who have reduced fucose N-glycans have reduced diversity, richness, and abundance of bifidobacteria[3], a commensal bacterium.
Disease risk[edit | edit source]
Non-secretors may have an increased risk of Crohn's disease[4] and type 1 diabetes,[5] but a decreased risk of norovirus[6] and helicobacter pylori[7] infection.
Learn more[edit | edit source]
- FUT2, Wiki genes
- 23andme - FUT2 gene- Norovirus Resistance
References[edit | edit source]
- ↑ Fucosyltransferase 2 non-secretor and low secretor status predicts severe outcomes in premature infants
- ↑ Fucose is not a dirty word, Evolutionary medicine
- ↑ Secretor Genotype (FUT2 gene) Is Strongly Associated with the Composition of Bifidobacteria in the Human Intestine
- ↑ Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. Hum Mol Genet. 2010 Sep 1;19(17):3468-76. doi: 10.1093/hmg/ddq248. Epub 2010 Jun 22.
- ↑ FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection, Diabetes. 2011 Nov;60(11):3081-4. doi: 10.2337/db11-0638.
- ↑ The G428A Nonsense Mutation in FUT2 Provides Strong but Not Absolute Protection against Symptomatic GII.4 Norovirus Infection PLoS ONE. 2009; 4(5): e5593. Published online 2009 May 18. doi: 10.1371/journal.pone.0005593
- ↑ Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa, Glycobiology. 2009 Dec;19(12):1525-36. doi: 10.1093/glycob/cwp131. Epub 2009 Aug 25.
