GETSET trial: Difference between revisions
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The protocol of the trial was published in ''JMIR Research Protocols'' in June 2016.<ref name="getsetprotocol" /> | The protocol of the trial was published in ''JMIR Research Protocols'' in June 2016.<ref name="getsetprotocol" /> | ||
== | ==Publications== | ||
The results were published on 22 June 2017 in the [[The Lancet|Lancet]] [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2816%2932589-2/fulltext | The results were published on 22 June 2017 in the [[The Lancet|Lancet]]: ''[http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2816%2932589-2/fulltext Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial]<ref>{{Cite journal | last = Clark | first = Lucy V. | last2 = Pesola | first2 = Francesca | last3 = Thomas | first3 = Janice M. | last4 = Vergara-Williamson | first4 = Mario | last5 = Beynon | first5 = Michelle | last6 = White | first6 = PeterD. | date = 2017-07-22 | title = Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial| url = https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32589-2/abstract|journal=The Lancet|language=English|volume=390|issue=10092 | pages = 363–373|doi=10.1016/S0140-6736(16)32589-2|issn=0140-6736|pmid=28648402}}</ref>'' | ||
Commentary was provided by | Commentary was provided by [[Daniel Clauw]] in the Lancet: [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30577-9/fulltext ''Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome''].<ref>{{Cite journal | last = Clauw | first = Daniel J | author-link = Daniel Clauw | date = Jul 2017 | title = Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome | url =https://linkinghub.elsevier.com/retrieve/pii/S0140673617305779|journal=The Lancet|language=en|volume=390|issue=10092 | pages = 335–336|doi=10.1016/S0140-6736(17)30577-9|pmc=|pmid=|access-date=|quote=|via=}}</ref> | ||
The [[Science Media Centre]] provided [http://www.sciencemediacentre.org/expert-reaction-to-study-on-guided-self-help-graded-exercise-therapy-as-a-treatment-for-chronic-fatigue-syndrome-cfs/ Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS)]. | The [[Science Media Centre]] provided: [http://www.sciencemediacentre.org/expert-reaction-to-study-on-guided-self-help-graded-exercise-therapy-as-a-treatment-for-chronic-fatigue-syndrome-cfs/ ''Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS)''].<ref>{{Cite web | url = https://www.sciencemediacentre.org/expert-reaction-to-study-on-guided-self-help-graded-exercise-therapy-as-a-treatment-for-chronic-fatigue-syndrome-cfs/ | title = expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS) {{!}} Science Media Centre|language=en-US|access-date=2020-05-08}}</ref> | ||
It was reported in the Telegraph as [http://www.telegraph.co.uk/science/2017/06/22/exercise-can-help-chronic-fatigue-syndrome-study-shows/ Exercise can help chronic fatigue syndrome, study shows] | It was reported in the Telegraph as [http://www.telegraph.co.uk/science/2017/06/22/exercise-can-help-chronic-fatigue-syndrome-study-shows/ Exercise can help chronic fatigue syndrome, study shows] and other media outlets: ''[http://www.emergency-live.com/en/news/defeating-chronic-fatigue-thanks-to-guided-self-help-approach-to-exercise/ Defeating chronic fatigue thanks to guided self-help approach to exercise].''<ref>{{Cite web | url = https://www.emergency-live.com/health-and-safety/defeating-chronic-fatigue-thanks-to-guided-self-help-approach-to-exercise/ | title = Defeating chronic fatigue thanks to guided self-help approach to exercise|website=Emergency Live|language=en-US|access-date=2020-05-08}}</ref> | ||
and | |||
The long term follow-up results were published July 2021 in the Journal of Psychosomatic Research: ''[https://doi.org/10.1016/j.jpsychores.2021.110484 Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial]''.<ref>{{Cite journal | title = Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial| date = 2021-07-01| url = https://www.sciencedirect.com/science/article/pii/S002239992100129X|journal=Journal of Psychosomatic Research|volume=146|pages=110484 | last = Clark | first = Lucy V. | last2 = McCrone | first2 = Paul | last3 = Pesola | first3 = Francesca | last4 = =Vergara-Williamson | first4 = Mario | last5 = White | first5 = Peter D.|language=en|doi=10.1016/j.jpsychores.2021.110484|issn=0022-3999}}</ref> | |||
==Criticism== | ==Criticism== | ||
Dr [[David Tuller]] | Dr [[David Tuller]] criticized the trial in the blog post [http://www.virology.ws/2017/06/28/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet/ Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet]. Tuller later also criticized misleading presentation of the long term follow-up results, which presented the results as demonstrating sustained improvement, despite them finding a lack of significant difference between the treated and untreated groups.<ref>{{Cite web | url = https://www.virology.ws/2021/04/06/trial-by-error-getset-study-reports-null-results-for-self-help-graded-exercise-but-declares-success-anyway/ | title = Trial By Error: GETSET Study Reports Null Results for Self-Help Graded Exercise–but Declares Success Anyway|website=www.virology.ws|access-date=2022-11-08}}</ref> The paper was subsequently revised in response to this criticism.<ref>{{Cite journal | title = Corrigendum to “Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial” [Journal of Psychosomatic Research 146 (2021) 110484]| date = 2021-09-01| url = https://www.sciencedirect.com/science/article/pii/S0022399921001872|journal=Journal of Psychosomatic Research|volume=148|pages=110542 | last = Clark | first = Lucy V. | last2 = McCrone | first2 = Paul | last3 = Pesola | first3 = Francesca | last4 = =Vergara-Williamson | first4 = Mario | last5 = White | first5 = Peter D.|language=en|doi=10.1016/j.jpsychores.2021.110542|issn=0022-3999}}</ref> | ||
[[Spoonseekerdotcom]] has criticised the GETSET trial.<ref> | [[Spoonseekerdotcom]] has criticised the GETSET trial.<ref>{{Cite web | url = https://spoonseeker.com/2016/05/23/a-few-notes-on-getset/ | title = A Few Notes on GETSET | last = Spoonseeker | first = Author | date = 2016-05-23 | website = spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref><ref>{{Cite web | url = https://spoonseeker.com/2017/06/29/do-get-yourself/ | title = Do GET Yourself | last = Spoonseeker | first = Author | date = 2017-06-29 | website = spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref><ref>{{Cite web | url = https://spoonseeker.com/2017/07/03/spotlight-on-getset-julie/ | title = Spotlight on GETSET Julie | last = Spoonseeker | first = Author | date = 2017-07-03 | website = spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref> | ||
Professor [[Jonathan Edwards]] criticised the study for its "incompetent level of science".<ref> | Professor [[Jonathan Edwards]] criticised the study for its "incompetent level of science".<ref>{{Cite web | url = https://forums.phoenixrising.me/threads/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet.52541/ | title = Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet | website = Phoenix Rising ME / CFS Forums|language=en-US|access-date=2020-01-26}}</ref> | ||
The [[ME Association]] | The [[ME Association]] also criticised the trial in [http://www.meassociation.org.uk/2017/06/me-association-review-getset-fails-to-demonstrate-get-can-significantly-improve-physical-function-28-june-2017/ ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function]. | ||
Additional criticism has been published by | Additional criticism has been published by other patients such as Lou Corsius and [[Cort Johnson]].<ref>{{Cite web | url = https://corsius.wordpress.com/2017/06/23/yet-another-publication-with-misleading-conclusions-from-pace-land/ | title = Yet another publication with misleading conclusions from PACE-land | last = Corsius | first = Lou | date = 2017-06-23 | website = it's about ME|language=nl|access-date=2020-01-26}} </ref><ref>{{Cite web | url = https://www.healthrising.org/blog/2017/06/25/graded-exercise-get-chronic-fatigue-syndrome-underwhelms/ | title = On Your Marks GETSET: Don't Go - Major Graded Exercise ME/CFS Trial Underwhelms (Again) | last = Johnson | first = Cort | date = 2017-06-26 | website = Health Rising|language=en-US|access-date=2020-01-26}} </ref> | ||
==Documents== | ==Documents== | ||
* Lead author Lucy Clark had previously published a | * Lead author Lucy Clark had previously published a booklet called [[:File:GET booklet web July 2009 2 .pdf | Graded Exercise Therapy - A self-help guide for those with chronic fatigue syndrome/myalgic encephalomyelitis]]. This booklet was apparently distributed to patients in the GETSET trial. | ||
==Learn more == | |||
*[https://spoonseeker.com/2016/05/23/a-few-notes-on-getset/ A few notes on GETSET] - Spoonseekerdotcom | |||
*[[Graded exercise therapy]] | |||
*[[Biopsychosocial model]] | |||
==See also== | ==See also== | ||
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==References== | ==References== | ||
<references> | <references> | ||
<ref name="getsetisrctn"> | <ref name="getsetisrctn">{{Cite web | url = http://www.isrctn.com/ISRCTN22975026 | title = ISRCTN - ISRCTN22975026: Graded Exercise Therapy guided SElf-help Treatment for CFS/ME | website = isrctn.com|language=en|access-date=2020-01-26}}</ref> | ||
<ref name="getsetprotocol">{{Citation | <ref name="getsetprotocol">{{Citation | doi = 10.2196/resprot.5395 | volume = 5 | issue = 2 | pages = 70 | last1 = Clark | first1 = Lucy V. | authorlink1 = Lucy Clark | last2 = McCrone | first2 = Paul | authorlink2 = Paul McCrone | last3 = Ridge | first3 = Damien | authorlink3 = Damien Ridge | last4 = Cheshire | first4 = Anna | authorlink4 = Anna Cheshire | last5 = Vergara-Williamson | first5 = Mario | authorlink5 = Mario Vergara-Williamson | last6 = Pesola | first6 = Francesca | authorlink6 = Francesco Pesola | last7 = White | first7 = PeterD. | author-link8 = Peter White | title = Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study | journal = JMIR research protocols | date = 2016-06-08 | pmid = 27278762 | pmc = 4917732 }}</ref> | ||
| doi = 10.2196/resprot.5395 | <ref name="getset">{{Citation | doi = 10.1016/S0140-6736(16)32589-2 | volume = | issue = | pages = | last1 = Clark | first1 = Lucy V. | authorlink1 = Lucy Clark | last2 = Pesola | first2 = Francesca | authorlink2 = Francesca Pesola | last3 = Thomas | first3 = Janice | authorlink3 = Janice Thomas | last4 = Vergara-Williamson | first4 = Mario | authorlink4 = Mario Vergara-Williamson | last5 = Beynon | first5 = Michelle | authorlink5 = Michelle Beynon | last6 = White | first6 = PeterD. | authorlink6 = Peter White | title = Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial | journal = The Lancet | date = 2017-06-22 | pmid = | pmc = }}</ref> | ||
| volume = 5 | |||
| last1 = Clark | |||
| last2 = McCrone | |||
| last3 = Ridge | |||
| last4 = Cheshire | |||
| last5 = Vergara-Williamson | |||
| last6 = Pesola | |||
| last7 = White | |||
| title = Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study | |||
| journal = JMIR research protocols | |||
| date = 2016-06-08 | |||
| pmid = 27278762 | pmc = 4917732 | |||
}} | |||
</ref> | |||
<ref name="getset">{{Citation | |||
| doi = 10.1016/S0140-6736(16)32589-2 | |||
| volume = | |||
| last1 = Clark | |||
| last2 = Pesola | |||
| last3 = Thomas | |||
| last4 = Vergara-Williamson | |||
| last5 = Beynon | |||
| last6 = White | |||
| title = Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial | |||
| journal = The Lancet | |||
| date = 2017-06-22 | |||
| pmid = | pmc = | |||
}} | |||
</ref> | |||
</references> | </references> | ||
[[Category:Psychological paradigm]] | [[Category:Psychological paradigm]] | ||
[[Category:Notable studies]] | [[Category:Notable studies]] |
Latest revision as of 06:53, April 20, 2023
The GETSET trial (short for Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome) was a trial investigating the effectiveness of "guided graded exercise self-help" in patients with CFS/ME. The protocol was published in June 2016.[1] The results were published in June 2017.[2]
Researchers[edit | edit source]
Lead Author Lucy Clark, Peter White, Francesca Pesola, Janice M Thomas, Mario Vergara-Williamson and Michelle Beynon
Funding[edit | edit source]
The trial was funded in full by the National Institute for Health Research's Research for Patient Benefit programme.[3]
Protocol[edit | edit source]
The protocol of the trial was published in JMIR Research Protocols in June 2016.[1]
Publications[edit | edit source]
The results were published on 22 June 2017 in the Lancet: Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial[4]
Commentary was provided by Daniel Clauw in the Lancet: Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome.[5]
The Science Media Centre provided: Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS).[6]
It was reported in the Telegraph as Exercise can help chronic fatigue syndrome, study shows and other media outlets: Defeating chronic fatigue thanks to guided self-help approach to exercise.[7]
The long term follow-up results were published July 2021 in the Journal of Psychosomatic Research: Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial.[8]
Criticism[edit | edit source]
Dr David Tuller criticized the trial in the blog post Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet. Tuller later also criticized misleading presentation of the long term follow-up results, which presented the results as demonstrating sustained improvement, despite them finding a lack of significant difference between the treated and untreated groups.[9] The paper was subsequently revised in response to this criticism.[10]
Spoonseekerdotcom has criticised the GETSET trial.[11][12][13]
Professor Jonathan Edwards criticised the study for its "incompetent level of science".[14]
The ME Association also criticised the trial in ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function.
Additional criticism has been published by other patients such as Lou Corsius and Cort Johnson.[15][16]
Documents[edit | edit source]
- Lead author Lucy Clark had previously published a booklet called Graded Exercise Therapy - A self-help guide for those with chronic fatigue syndrome/myalgic encephalomyelitis. This booklet was apparently distributed to patients in the GETSET trial.
Learn more[edit | edit source]
- A few notes on GETSET - Spoonseekerdotcom
- Graded exercise therapy
- Biopsychosocial model
See also[edit | edit source]
References[edit | edit source]
- ↑ 1.0 1.1 Clark, Lucy V.; McCrone, Paul; Ridge, Damien; Cheshire, Anna; Vergara-Williamson, Mario; Pesola, Francesca; White, PeterD. (June 8, 2016), "Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study", JMIR research protocols, 5 (2): 70, doi:10.2196/resprot.5395, PMC 4917732, PMID 27278762
- ↑ Clark, Lucy V.; Pesola, Francesca; Thomas, Janice; Vergara-Williamson, Mario; Beynon, Michelle; White, PeterD. (June 22, 2017), "Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial", The Lancet, doi:10.1016/S0140-6736(16)32589-2
- ↑ "ISRCTN - ISRCTN22975026: Graded Exercise Therapy guided SElf-help Treatment for CFS/ME". isrctn.com. Retrieved January 26, 2020.
- ↑ Clark, Lucy V.; Pesola, Francesca; Thomas, Janice M.; Vergara-Williamson, Mario; Beynon, Michelle; White, PeterD. (July 22, 2017). "Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial". The Lancet. 390 (10092): 363–373. doi:10.1016/S0140-6736(16)32589-2. ISSN 0140-6736. PMID 28648402.
- ↑ Clauw, Daniel J (July 2017). "Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome". The Lancet. 390 (10092): 335–336. doi:10.1016/S0140-6736(17)30577-9.
- ↑ "expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS) | Science Media Centre". Retrieved May 8, 2020.
- ↑ "Defeating chronic fatigue thanks to guided self-help approach to exercise". Emergency Live. Retrieved May 8, 2020.
- ↑ Clark, Lucy V.; McCrone, Paul; Pesola, Francesca; =Vergara-Williamson, Mario; White, Peter D. (July 1, 2021). "Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial". Journal of Psychosomatic Research. 146: 110484. doi:10.1016/j.jpsychores.2021.110484. ISSN 0022-3999.
- ↑ "Trial By Error: GETSET Study Reports Null Results for Self-Help Graded Exercise–but Declares Success Anyway". www.virology.ws. Retrieved November 8, 2022.
- ↑ Clark, Lucy V.; McCrone, Paul; Pesola, Francesca; =Vergara-Williamson, Mario; White, Peter D. (September 1, 2021). "Corrigendum to "Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial" [Journal of Psychosomatic Research 146 (2021) 110484]". Journal of Psychosomatic Research. 148: 110542. doi:10.1016/j.jpsychores.2021.110542. ISSN 0022-3999.
- ↑ Spoonseeker, Author (May 23, 2016). "A Few Notes on GETSET". spoonseekerdotcom. Retrieved January 26, 2020.
- ↑ Spoonseeker, Author (June 29, 2017). "Do GET Yourself". spoonseekerdotcom. Retrieved January 26, 2020.
- ↑ Spoonseeker, Author (July 3, 2017). "Spotlight on GETSET Julie". spoonseekerdotcom. Retrieved January 26, 2020.
- ↑ "Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet". Phoenix Rising ME / CFS Forums. Retrieved January 26, 2020.
- ↑ Corsius, Lou (June 23, 2017). "Yet another publication with misleading conclusions from PACE-land". it's about ME (in Nederlands). Retrieved January 26, 2020.
- ↑ Johnson, Cort (June 26, 2017). "On Your Marks GETSET: Don't Go - Major Graded Exercise ME/CFS Trial Underwhelms (Again)". Health Rising. Retrieved January 26, 2020.