GETSET trial: Difference between revisions

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The protocol of the trial was published in ''JMIR Research Protocols'' in June 2016.<ref name="getsetprotocol" />
The protocol of the trial was published in ''JMIR Research Protocols'' in June 2016.<ref name="getsetprotocol" />


==Publication==
==Publications==
The results were published on 22 June 2017 in the [[The Lancet|Lancet]] [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2816%2932589-2/fulltext 'Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial'] <ref>[[QMUL]] Press release: [http://www.qmul.ac.uk/media/news/items/smd/198480.html# Guided self-help approach to graded exercise programme is safe and may reduce fatigue for patients with chronic fatigue syndrome]  </ref> .
The results were published on 22 June 2017 in the [[The Lancet|Lancet]]: ''[http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2816%2932589-2/fulltext Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial]<ref>{{Cite journal | last = Clark | first = Lucy V. | last2 = Pesola | first2 = Francesca | last3 = Thomas | first3 = Janice M. | last4 = Vergara-Williamson | first4 = Mario | last5 = Beynon | first5 = Michelle | last6 = White | first6 = PeterD. | date = 2017-07-22 | title = Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial| url = https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32589-2/abstract|journal=The Lancet|language=English|volume=390|issue=10092 | pages = 363–373|doi=10.1016/S0140-6736(16)32589-2|issn=0140-6736|pmid=28648402}}</ref>''


Commentary was provided by [[Daniel Claw]] in the Lancet [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30577-9/fulltext Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome].
Commentary was provided by [[Daniel Clauw]] in the Lancet: [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30577-9/fulltext ''Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome''].<ref>{{Cite journal | last = Clauw | first = Daniel J | author-link = Daniel Clauw | date = Jul 2017 | title = Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome | url =https://linkinghub.elsevier.com/retrieve/pii/S0140673617305779|journal=The Lancet|language=en|volume=390|issue=10092 | pages = 335–336|doi=10.1016/S0140-6736(17)30577-9|pmc=|pmid=|access-date=|quote=|via=}}</ref>


The [[Science Media Centre]]  provided  [http://www.sciencemediacentre.org/expert-reaction-to-study-on-guided-self-help-graded-exercise-therapy-as-a-treatment-for-chronic-fatigue-syndrome-cfs/ Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS)].
The [[Science Media Centre]]  provided: [http://www.sciencemediacentre.org/expert-reaction-to-study-on-guided-self-help-graded-exercise-therapy-as-a-treatment-for-chronic-fatigue-syndrome-cfs/ ''Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS)''].<ref>{{Cite web |  url = https://www.sciencemediacentre.org/expert-reaction-to-study-on-guided-self-help-graded-exercise-therapy-as-a-treatment-for-chronic-fatigue-syndrome-cfs/ | title = expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS) {{!}} Science Media Centre|language=en-US|access-date=2020-05-08}}</ref>


It was reported in the Telegraph as [http://www.telegraph.co.uk/science/2017/06/22/exercise-can-help-chronic-fatigue-syndrome-study-shows/ Exercise can help chronic fatigue syndrome, study shows]
It was reported in the Telegraph as [http://www.telegraph.co.uk/science/2017/06/22/exercise-can-help-chronic-fatigue-syndrome-study-shows/ Exercise can help chronic fatigue syndrome, study shows] and other media outlets: ''[http://www.emergency-live.com/en/news/defeating-chronic-fatigue-thanks-to-guided-self-help-approach-to-exercise/ Defeating chronic fatigue thanks to guided self-help approach to exercise].''<ref>{{Cite web |  url = https://www.emergency-live.com/health-and-safety/defeating-chronic-fatigue-thanks-to-guided-self-help-approach-to-exercise/ | title = Defeating chronic fatigue thanks to guided self-help approach to exercise|website=Emergency Live|language=en-US|access-date=2020-05-08}}</ref>
and other media outlets [http://www.emergency-live.com/en/news/defeating-chronic-fatigue-thanks-to-guided-self-help-approach-to-exercise/ Defeating chronic fatigue thanks to guided self-help approach to exercise].
 
The long term follow-up results were published July 2021 in the Journal of Psychosomatic Research: ''[https://doi.org/10.1016/j.jpsychores.2021.110484 Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial]''.<ref>{{Cite journal | title = Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial| date = 2021-07-01| url = https://www.sciencedirect.com/science/article/pii/S002239992100129X|journal=Journal of Psychosomatic Research|volume=146|pages=110484 | last = Clark | first = Lucy V. | last2 = McCrone | first2 = Paul | last3 = Pesola | first3 = Francesca | last4 = =Vergara-Williamson | first4 = Mario | last5 = White | first5 = Peter D.|language=en|doi=10.1016/j.jpsychores.2021.110484|issn=0022-3999}}</ref>


==Criticism==
==Criticism==
Dr [[David Tuller]] has criticised the trial [http://www.virology.ws/2017/06/28/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet/ Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet].  
Dr [[David Tuller]] criticized the trial in the blog post [http://www.virology.ws/2017/06/28/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet/ Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet]. Tuller later also criticized misleading presentation of the long term follow-up results, which presented the results as demonstrating sustained improvement, despite them finding a lack of significant difference between the treated and untreated groups.<ref>{{Cite web |  url = https://www.virology.ws/2021/04/06/trial-by-error-getset-study-reports-null-results-for-self-help-graded-exercise-but-declares-success-anyway/ | title = Trial By Error: GETSET Study Reports Null Results for Self-Help Graded Exercise–but Declares Success Anyway|website=www.virology.ws|access-date=2022-11-08}}</ref> The paper was subsequently revised in response to this criticism.<ref>{{Cite journal | title = Corrigendum to “Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial” [Journal of Psychosomatic Research 146 (2021) 110484]| date = 2021-09-01| url = https://www.sciencedirect.com/science/article/pii/S0022399921001872|journal=Journal of Psychosomatic Research|volume=148|pages=110542 | last = Clark | first = Lucy V. | last2 = McCrone | first2 = Paul | last3 = Pesola | first3 = Francesca | last4 = =Vergara-Williamson | first4 = Mario | last5 = White | first5 = Peter D.|language=en|doi=10.1016/j.jpsychores.2021.110542|issn=0022-3999}}</ref>


[[Spoonseekerdotcom]] has criticised the GETSET trial.<ref>23 May 2016, [https://spoonseeker.com/2016/05/23/a-few-notes-on-getset/ Spoonseekerdotcom - A Few Notes on GETSET]</ref><ref>29 June 2017, [https://spoonseeker.com/2017/06/29/do-get-yourself/ Do GET Yourself]</ref> <ref>[https://spoonseeker.com/2017/07/03/spotlight-on-getset-julie/ Spotlight on GETSET Julie]</ref>
[[Spoonseekerdotcom]] has criticised the GETSET trial.<ref>{{Cite web |  url = https://spoonseeker.com/2016/05/23/a-few-notes-on-getset/ | title = A Few Notes on GETSET | last = Spoonseeker | first = Author | date = 2016-05-23 | website = spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref><ref>{{Cite web |  url = https://spoonseeker.com/2017/06/29/do-get-yourself/ | title = Do GET Yourself | last = Spoonseeker | first = Author | date = 2017-06-29 | website = spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref><ref>{{Cite web |  url = https://spoonseeker.com/2017/07/03/spotlight-on-getset-julie/ | title = Spotlight on GETSET Julie | last = Spoonseeker | first = Author | date = 2017-07-03 | website = spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref>


Professor [[Jonathan Edwards]] criticised the study for its "incompetent level of science".<ref>[http://forums.phoenixrising.me/index.php?threads/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet.52541/page-2#post-869797 Phoenix Rising Forum - Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet]</ref>
Professor [[Jonathan Edwards]] criticised the study for its "incompetent level of science".<ref>{{Cite web |  url = https://forums.phoenixrising.me/threads/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet.52541/ | title = Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet | website = Phoenix Rising ME / CFS Forums|language=en-US|access-date=2020-01-26}}</ref>


The [[ME Association]] has also criticised the trial [http://www.meassociation.org.uk/2017/06/me-association-review-getset-fails-to-demonstrate-get-can-significantly-improve-physical-function-28-june-2017/ ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function].
The [[ME Association]] also criticised the trial in [http://www.meassociation.org.uk/2017/06/me-association-review-getset-fails-to-demonstrate-get-can-significantly-improve-physical-function-28-june-2017/ ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function].


Additional criticism has been published by other patients <ref>https://corsius.wordpress.com/2017/06/23/yet-another-publication-with-misleading-conclusions-from-pace-land/amp/   </ref> <ref>https://www.healthrising.org/blog/2017/06/25/graded-exercise-get-chronic-fatigue-syndrome-underwhelms/  </ref>.
Additional criticism has been published by other patients such as Lou Corsius and [[Cort Johnson]].<ref>{{Cite web |  url = https://corsius.wordpress.com/2017/06/23/yet-another-publication-with-misleading-conclusions-from-pace-land/ | title = Yet another publication with misleading conclusions from PACE-land | last = Corsius | first = Lou | date = 2017-06-23 | website = it's about ME|language=nl|access-date=2020-01-26}}   </ref><ref>{{Cite web |  url = https://www.healthrising.org/blog/2017/06/25/graded-exercise-get-chronic-fatigue-syndrome-underwhelms/ | title = On Your Marks GETSET: Don't Go - Major Graded Exercise ME/CFS Trial Underwhelms (Again) | last = Johnson | first = Cort | date = 2017-06-26 | website = Health Rising|language=en-US|access-date=2020-01-26}} </ref>


==Documents==
==Documents==
* Lead author Lucy Clark had previously published a book called "Graded Exercise Therapy - A self-help guide for those with chronic fatigue syndrome/myalgic encephalomyelitis"
* Lead author Lucy Clark had previously published a booklet called [[:File:GET booklet web July 2009 2 .pdf | Graded Exercise Therapy - A self-help guide for those with chronic fatigue syndrome/myalgic encephalomyelitis]].  This booklet was apparently distributed to patients in the GETSET trial.
 
==Learn more ==
*[https://spoonseeker.com/2016/05/23/a-few-notes-on-getset/ A few notes on GETSET] - Spoonseekerdotcom
*[[Graded exercise therapy]]
*[[Biopsychosocial model]]


==See also==
==See also==
Line 39: Line 45:
==References==
==References==
<references>
<references>
<ref name="getsetisrctn">[http://www.isrctn.com/ISRCTN22975026 ISRCTN Registry - GETSET trial (ISRCTN22975026)]</ref>
<ref name="getsetisrctn">{{Cite web |  url = http://www.isrctn.com/ISRCTN22975026 | title = ISRCTN - ISRCTN22975026: Graded Exercise Therapy guided SElf-help Treatment for CFS/ME | website = isrctn.com|language=en|access-date=2020-01-26}}</ref>
<ref name="getsetprotocol">{{Citation
<ref name="getsetprotocol">{{Citation | doi = 10.2196/resprot.5395 | volume = 5 | issue = 2   | pages = 70 | last1 = Clark | first1 = Lucy V. | authorlink1 = Lucy Clark | last2 = McCrone | first2 = Paul | authorlink2 = Paul McCrone | last3 = Ridge | first3 = Damien | authorlink3 =  Damien Ridge | last4 = Cheshire | first4 = Anna | authorlink4 = Anna Cheshire | last5 = Vergara-Williamson | first5 = Mario | authorlink5 = Mario Vergara-Williamson | last6 = Pesola | first6 = Francesca | authorlink6 = Francesco Pesola | last7 = White | first7 = PeterD. | author-link8 = Peter White | title = Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study | journal = JMIR research protocols | date = 2016-06-08 | pmid = 27278762              | pmc = 4917732 }}</ref>
| doi = 10.2196/resprot.5395
<ref name="getset">{{Citation | doi = 10.1016/S0140-6736(16)32589-2 | volume = | issue =   | pages = | last1 = Clark | first1 = Lucy V. | authorlink1 = Lucy Clark | last2 = Pesola | first2 = Francesca | authorlink2 = Francesca Pesola | last3 = Thomas | first3 = Janice | authorlink3 = Janice Thomas | last4 = Vergara-Williamson | first4 = Mario | authorlink4 = Mario Vergara-Williamson | last5 = Beynon | first5 = Michelle | authorlink5 = Michelle Beynon | last6 = White | first6 = PeterD. | authorlink6 = Peter White | title = Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial | journal = The Lancet | date = 2017-06-22 | pmid =              | pmc = }}</ref>
| volume = 5                 | issue = 2                     | pages = 70
| last1 = Clark                               | first1 = Lucy V. | authorlink1 = Lucy Clark
| last2 = McCrone                         | first2 = Paul | authorlink2 = Paul McCrone
| last3 = Ridge                               | first3 = Damien | authorlink3 =  Damien Ridge
| last4 = Cheshire                         | first4 = Anna | authorlink4 = Anna Cheshire
| last5 = Vergara-Williamson         | first5 = Mario | authorlink5 = Mario Vergara-Williamson
| last6 = Pesola                             | first6 = Francesca | authorlink6 = Francesco Pesola
| last7 = White                               | first7 = Peter D. | authorlink7 = Peter White
| title = Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study
| journal = JMIR research protocols
| date = 2016-06-08
| pmid = 27278762              | pmc = 4917732
}}
</ref>
<ref name="getset">{{Citation
| doi = 10.1016/S0140-6736(16)32589-2
| volume =                 | issue =                       | pages =  
| last1 = Clark                               | first1 = Lucy V. | authorlink1 = Lucy Clark
| last2 = Pesola                           | first2 = Francesca | authorlink2 = Francesca Pesola
| last3 = Thomas                         | first3 = Janice | authorlink3 = Janice Thomas
| last4 = Vergara-Williamson   | first4 = Mario | authorlink4 = Mario Vergara-Williamson
| last5 = Beynon                         | first5 = Michelle | authorlink5 = Michelle Beynon
| last6 = White                             | first6 = Peter D. | authorlink6 = Peter White
| title = Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial
| journal = The Lancet
| date = 2017-06-22
| pmid =              | pmc =
}}
</ref>
</references>
</references>


[[Category:Psychological paradigm]]  
[[Category:Psychological paradigm]]  
[[Category:Notable studies]]
[[Category:Notable studies]]

Latest revision as of 06:53, April 20, 2023

The GETSET trial (short for Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome) was a trial investigating the effectiveness of "guided graded exercise self-help" in patients with CFS/ME. The protocol was published in June 2016.[1] The results were published in June 2017.[2]

Researchers[edit | edit source]

Lead Author Lucy Clark, Peter White, Francesca Pesola, Janice M Thomas, Mario Vergara-Williamson and Michelle Beynon

Funding[edit | edit source]

The trial was funded in full by the National Institute for Health Research's Research for Patient Benefit programme.[3]

Protocol[edit | edit source]

The protocol of the trial was published in JMIR Research Protocols in June 2016.[1]

Publications[edit | edit source]

The results were published on 22 June 2017 in the Lancet: Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial[4]

Commentary was provided by Daniel Clauw in the Lancet: Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome.[5]

The Science Media Centre provided: Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS).[6]

It was reported in the Telegraph as Exercise can help chronic fatigue syndrome, study shows and other media outlets: Defeating chronic fatigue thanks to guided self-help approach to exercise.[7]

The long term follow-up results were published July 2021 in the Journal of Psychosomatic Research: Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial.[8]

Criticism[edit | edit source]

Dr David Tuller criticized the trial in the blog post Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet. Tuller later also criticized misleading presentation of the long term follow-up results, which presented the results as demonstrating sustained improvement, despite them finding a lack of significant difference between the treated and untreated groups.[9] The paper was subsequently revised in response to this criticism.[10]

Spoonseekerdotcom has criticised the GETSET trial.[11][12][13]

Professor Jonathan Edwards criticised the study for its "incompetent level of science".[14]

The ME Association also criticised the trial in ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function.

Additional criticism has been published by other patients such as Lou Corsius and Cort Johnson.[15][16]

Documents[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 Clark, Lucy V.; McCrone, Paul; Ridge, Damien; Cheshire, Anna; Vergara-Williamson, Mario; Pesola, Francesca; White, PeterD. (June 8, 2016), "Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study", JMIR research protocols, 5 (2): 70, doi:10.2196/resprot.5395, PMC 4917732, PMID 27278762
  2. Clark, Lucy V.; Pesola, Francesca; Thomas, Janice; Vergara-Williamson, Mario; Beynon, Michelle; White, PeterD. (June 22, 2017), "Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial", The Lancet, doi:10.1016/S0140-6736(16)32589-2
  3. "ISRCTN - ISRCTN22975026: Graded Exercise Therapy guided SElf-help Treatment for CFS/ME". isrctn.com. Retrieved January 26, 2020.
  4. Clark, Lucy V.; Pesola, Francesca; Thomas, Janice M.; Vergara-Williamson, Mario; Beynon, Michelle; White, PeterD. (July 22, 2017). "Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial". The Lancet. 390 (10092): 363–373. doi:10.1016/S0140-6736(16)32589-2. ISSN 0140-6736. PMID 28648402.
  5. Clauw, Daniel J (July 2017). "Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome". The Lancet. 390 (10092): 335–336. doi:10.1016/S0140-6736(17)30577-9.
  6. "expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS) | Science Media Centre". Retrieved May 8, 2020.
  7. "Defeating chronic fatigue thanks to guided self-help approach to exercise". Emergency Live. Retrieved May 8, 2020.
  8. Clark, Lucy V.; McCrone, Paul; Pesola, Francesca; =Vergara-Williamson, Mario; White, Peter D. (July 1, 2021). "Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial". Journal of Psychosomatic Research. 146: 110484. doi:10.1016/j.jpsychores.2021.110484. ISSN 0022-3999.
  9. "Trial By Error: GETSET Study Reports Null Results for Self-Help Graded Exercise–but Declares Success Anyway". www.virology.ws. Retrieved November 8, 2022.
  10. Clark, Lucy V.; McCrone, Paul; Pesola, Francesca; =Vergara-Williamson, Mario; White, Peter D. (September 1, 2021). "Corrigendum to "Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial" [Journal of Psychosomatic Research 146 (2021) 110484]". Journal of Psychosomatic Research. 148: 110542. doi:10.1016/j.jpsychores.2021.110542. ISSN 0022-3999.
  11. Spoonseeker, Author (May 23, 2016). "A Few Notes on GETSET". spoonseekerdotcom. Retrieved January 26, 2020.
  12. Spoonseeker, Author (June 29, 2017). "Do GET Yourself". spoonseekerdotcom. Retrieved January 26, 2020.
  13. Spoonseeker, Author (July 3, 2017). "Spotlight on GETSET Julie". spoonseekerdotcom. Retrieved January 26, 2020.
  14. "Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet". Phoenix Rising ME / CFS Forums. Retrieved January 26, 2020.
  15. Corsius, Lou (June 23, 2017). "Yet another publication with misleading conclusions from PACE-land". it's about ME (in Nederlands). Retrieved January 26, 2020.
  16. Johnson, Cort (June 26, 2017). "On Your Marks GETSET: Don't Go - Major Graded Exercise ME/CFS Trial Underwhelms (Again)". Health Rising. Retrieved January 26, 2020.