GETSET trial: Difference between revisions

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
(→‎Documents: fix dead link)
m (→‎Publication: bare external link in ref)
(One intermediate revision by the same user not shown)
Line 11: Line 11:


==Publication==
==Publication==
The results were published on 22 June 2017 in the [[The Lancet|Lancet]] [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2816%2932589-2/fulltext 'Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial'] <ref>[[QMUL]] Press release:  [http://www.qmul.ac.uk/media/news/items/smd/198480.html# Guided self-help approach to graded exercise programme is safe and may reduce fatigue for patients with chronic fatigue syndrome</ref> .
The results were published on 22 June 2017 in the [[The Lancet|Lancet]] [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2816%2932589-2/fulltext 'Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial'] <ref>http://www.qmul.ac.uk/media/news/items/smd/198480.html# Guided self-help approach to graded exercise programme is safe and may reduce fatigue for patients with chronic fatigue syndrome</ref>{{Dead link|date=26 January 2020}}


Commentary was provided by  [[Daniel Claw]] in the Lancet [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30577-9/fulltext Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome].
Commentary was provided by  [[Daniel Claw]] in the Lancet [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30577-9/fulltext Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome].
Line 17: Line 17:
The [[Science Media Centre]]  provided  [http://www.sciencemediacentre.org/expert-reaction-to-study-on-guided-self-help-graded-exercise-therapy-as-a-treatment-for-chronic-fatigue-syndrome-cfs/ Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS)].
The [[Science Media Centre]]  provided  [http://www.sciencemediacentre.org/expert-reaction-to-study-on-guided-self-help-graded-exercise-therapy-as-a-treatment-for-chronic-fatigue-syndrome-cfs/ Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS)].


It was reported in the Telegraph as [http://www.telegraph.co.uk/science/2017/06/22/exercise-can-help-chronic-fatigue-syndrome-study-shows/ Exercise can help chronic fatigue syndrome, study shows]
It was reported in the Telegraph as [http://www.telegraph.co.uk/science/2017/06/22/exercise-can-help-chronic-fatigue-syndrome-study-shows/ Exercise can help chronic fatigue syndrome, study shows] and other media outlets [http://www.emergency-live.com/en/news/defeating-chronic-fatigue-thanks-to-guided-self-help-approach-to-exercise/ Defeating chronic fatigue thanks to guided self-help approach to exercise].
and other media outlets [http://www.emergency-live.com/en/news/defeating-chronic-fatigue-thanks-to-guided-self-help-approach-to-exercise/ Defeating chronic fatigue thanks to guided self-help approach to exercise].


==Criticism==
==Criticism==
Dr [[David Tuller]] has criticised the trial [http://www.virology.ws/2017/06/28/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet/ Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet].  
Dr [[David Tuller]] has criticised the trial [http://www.virology.ws/2017/06/28/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet/ Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet].  


[[Spoonseekerdotcom]] has criticised the GETSET trial.<ref>23 May 2016, [https://spoonseeker.com/2016/05/23/a-few-notes-on-getset/ Spoonseekerdotcom - A Few Notes on GETSET]</ref><ref>29 June 2017, [https://spoonseeker.com/2017/06/29/do-get-yourself/ Do GET Yourself]</ref> <ref>[https://spoonseeker.com/2017/07/03/spotlight-on-getset-julie/ Spotlight on GETSET Julie]</ref>
[[Spoonseekerdotcom]] has criticised the GETSET trial.<ref>{{Cite web|url=https://spoonseeker.com/2016/05/23/a-few-notes-on-getset/|title=A Few Notes on GETSET|last=Spoonseeker|first=Author|date=2016-05-23|website=spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref><ref>{{Cite web|url=https://spoonseeker.com/2017/06/29/do-get-yourself/|title=Do GET Yourself|last=Spoonseeker|first=Author|date=2017-06-29|website=spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref> <ref>{{Cite web|url=https://spoonseeker.com/2017/07/03/spotlight-on-getset-julie/|title=Spotlight on GETSET Julie|last=Spoonseeker|first=Author|date=2017-07-03|website=spoonseekerdotcom|language=en|access-date=2020-01-26}}</ref>


Professor [[Jonathan Edwards]] criticised the study for its "incompetent level of science".<ref>[http://forums.phoenixrising.me/index.php?threads/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet.52541/page-2#post-869797 Phoenix Rising Forum - Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet]</ref>
Professor [[Jonathan Edwards]] criticised the study for its "incompetent level of science".<ref>{{Cite web|url=https://forums.phoenixrising.me/threads/trial-by-error-continued-more-on-graded-exercise-from-peter-white-and-the-lancet.52541/|title=Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet|website=Phoenix Rising ME / CFS Forums|language=en-US|access-date=2020-01-26}}</ref>


The [[ME Association]]  has also criticised the trial [http://www.meassociation.org.uk/2017/06/me-association-review-getset-fails-to-demonstrate-get-can-significantly-improve-physical-function-28-june-2017/ ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function].
The [[ME Association]]  has also criticised the trial [http://www.meassociation.org.uk/2017/06/me-association-review-getset-fails-to-demonstrate-get-can-significantly-improve-physical-function-28-june-2017/ ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function].


Additional criticism has been published by  other patients <ref>https://corsius.wordpress.com/2017/06/23/yet-another-publication-with-misleading-conclusions-from-pace-land/amp/   </ref> <ref>https://www.healthrising.org/blog/2017/06/25/graded-exercise-get-chronic-fatigue-syndrome-underwhelms/  </ref>.
Additional criticism has been published by  other patients <ref>{{Cite web|url=https://corsius.wordpress.com/2017/06/23/yet-another-publication-with-misleading-conclusions-from-pace-land/|title=Yet another publication with misleading conclusions from PACE-land|last=Corsius|first=Lou|date=2017-06-23|website=it's about ME|language=nl|access-date=2020-01-26}}   </ref> <ref>{{Cite web|url=https://www.healthrising.org/blog/2017/06/25/graded-exercise-get-chronic-fatigue-syndrome-underwhelms/|title=On Your Marks GETSET: Don't Go - Major Graded Exercise ME/CFS Trial Underwhelms (Again)|last=Johnson|first=Cort|date=2017-06-26|website=Health Rising|language=en-US|access-date=2020-01-26}} </ref>.


==Documents==
==Documents==
Line 39: Line 38:
==References==
==References==
<references>
<references>
<ref name="getsetisrctn">[http://www.isrctn.com/ISRCTN22975026 ISRCTN Registry - GETSET trial (ISRCTN22975026)]</ref>
<ref name="getsetisrctn">{{Cite web|url=http://www.isrctn.com/ISRCTN22975026|title=ISRCTN - ISRCTN22975026: Graded Exercise Therapy guided SElf-help Treatment for CFS/ME|website=www.isrctn.com|language=en|access-date=2020-01-26}}</ref>
<ref name="getsetprotocol">{{Citation
<ref name="getsetprotocol">{{Citation
| doi = 10.2196/resprot.5395
| doi = 10.2196/resprot.5395

Revision as of 00:11, January 27, 2020

The GETSET trial (short for Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome) was a trial investigating the effectiveness of "guided graded exercise self-help" in patients with CFS/ME. The protocol was published in June 2016.[1] The results were published in June 2017.[2]

Researchers[edit | edit source]

Lead Author Lucy Clark, Peter White, Francesca Pesola, Janice M Thomas, Mario Vergara-Williamson and Michelle Beynon

Funding[edit | edit source]

The trial was funded in full by the National Institute for Health Research's Research for Patient Benefit programme.[3]

Protocol[edit | edit source]

The protocol of the trial was published in JMIR Research Protocols in June 2016.[1]

Publication[edit | edit source]

The results were published on 22 June 2017 in the Lancet 'Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial' [4][dead link]

Commentary was provided by Daniel Claw in the Lancet Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome.

The Science Media Centre provided Expert reaction to study on guided self-help graded exercise therapy as a treatment for chronic fatigue syndrome (CFS).

It was reported in the Telegraph as Exercise can help chronic fatigue syndrome, study shows and other media outlets Defeating chronic fatigue thanks to guided self-help approach to exercise.

Criticism[edit | edit source]

Dr David Tuller has criticised the trial Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet.

Spoonseekerdotcom has criticised the GETSET trial.[5][6] [7]

Professor Jonathan Edwards criticised the study for its "incompetent level of science".[8]

The ME Association has also criticised the trial ME Association Review: GETSET fails to demonstrate GET can significantly improve physical function.

Additional criticism has been published by other patients [9] [10].

Documents[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 Clark, Lucy V.; McCrone, Paul; Ridge, Damien; Cheshire, Anna; Vergara-Williamson, Mario; Pesola, Francesca; White, Peter D. (June 8, 2016), "Graded Exercise Therapy Guided Self-Help Trial for Patients with Chronic Fatigue Syndrome (GETSET): Protocol for a Randomized Controlled Trial and Interview Study", JMIR research protocols, 5 (2): 70, doi:10.2196/resprot.5395, PMC 4917732, PMID 27278762
  2. Clark, Lucy V.; Pesola, Francesca; Thomas, Janice; Vergara-Williamson, Mario; Beynon, Michelle; White, Peter D. (June 22, 2017), "Guided graded exercise self-help plus specialist medical care versus specialist medical care alone for chronic fatigue syndrome (GETSET): a pragmatic randomised controlled trial", The Lancet, doi:10.1016/S0140-6736(16)32589-2
  3. "ISRCTN - ISRCTN22975026: Graded Exercise Therapy guided SElf-help Treatment for CFS/ME". www.isrctn.com. Retrieved January 26, 2020.
  4. http://www.qmul.ac.uk/media/news/items/smd/198480.html# Guided self-help approach to graded exercise programme is safe and may reduce fatigue for patients with chronic fatigue syndrome
  5. Spoonseeker, Author (May 23, 2016). "A Few Notes on GETSET". spoonseekerdotcom. Retrieved January 26, 2020.
  6. Spoonseeker, Author (June 29, 2017). "Do GET Yourself". spoonseekerdotcom. Retrieved January 26, 2020.
  7. Spoonseeker, Author (July 3, 2017). "Spotlight on GETSET Julie". spoonseekerdotcom. Retrieved January 26, 2020.
  8. "Trial by Error, Continued: More on Graded Exercise from Peter White and The Lancet". Phoenix Rising ME / CFS Forums. Retrieved January 26, 2020.
  9. Corsius, Lou (June 23, 2017). "Yet another publication with misleading conclusions from PACE-land". it's about ME (in Nederlands). Retrieved January 26, 2020.
  10. Johnson, Cort (June 26, 2017). "On Your Marks GETSET: Don't Go - Major Graded Exercise ME/CFS Trial Underwhelms (Again)". Health Rising. Retrieved January 26, 2020.