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Haptoglobin
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'''Haptoglobin''' Haptoglobin (HP) is a hemoglobin-binding protein with immunomodulatory properties. Its gene harbors a common polymorphism with 2 different alleles: HP1 and HP2. Allele HP2 and genotype HP22 has been shown to be overrepresented in different immune diseases like [[Rheumatoid Arthritis]] (RA), [[Systemic Lupus Erythematosus]] (SLE) and [[diabetes#Type_1|type 1 diabetes]], and has also been found to be more frequent in patients with [[irritable bowel disease]] ([[ulcerative colitis]] and [[Crohn's disease]]) than in healthy controls.<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943850/ The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease], Tim Vanuytsel, Séverine Vermeire, and Isabelle Cleynen, Tissue Barriers. 2013 Dec 1; 1(5): e27321.</ref> ==See also== *[[Zonulin]] ==References== {{Reflist}} [[Category:Genes]] [[Category:Proteins]]
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