Haptoglobin

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Haptoglobin

Haptoglobin (HP) is a hemoglobin-binding protein with immunomodulatory properties. Its gene harbors a common polymorphism with 2 different alleles: HP1 and HP2. Allele HP2 and genotype HP22 has been shown to be overrepresented in different immune diseases like Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE) and type 1 diabetes, and has also been found to be more frequent in patients with irritable bowel disease (ulcerative colitis and Crohn's disease) than in healthy controls.[1]


See also[edit | edit source]

References[edit | edit source]

  1. The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease, Tim Vanuytsel, Séverine Vermeire, and Isabelle Cleynen, Tissue Barriers. 2013 Dec 1; 1(5): e27321.