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Human herpesvirus 6
(section)
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===Multiple sclerosis=== HHV-6 has been found in the [[oligodendrocyte]]s of plaques in MS patients but not in healthy tissue.<ref>{{Cite journal | last = Challoner | first = P.B. | last2 = Smith | first2 = K.T. | last3 = Parker | first3 = J.D. | last4 = MacLeod | first4 =D.L. | last5 = Coulter | first5 = S.N. | last6 = Rose | first6 = T.M. | last7 = Schultz | first7 = E.R. | last8 = Bennett | first8 = J.L. | last9 = Garber | first9 = R.L. | date = 1995-08-01 | title = Plaque-associated expression of human herpesvirus 6 in multiple sclerosis | url = https://www.ncbi.nlm.nih.gov/pubmed/7638210/|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=92|issue=16 | pages = 7440–7444|doi=10.1073/pnas.92.16.7440|issn=0027-8424|pmid=7638210}}</ref> Antivirals may have some therapeutic benefit. A randomized, placebo-controlled double-blind study found that [[acyclovir]] reduced the exacerbation rate in relapsing-remitting MS patients.<ref>{{Cite journal | last = Lycke | first = J. | authorlink = | last2 = Svennerholm | first2 = B. | authorlink2 = | last3 = Hjelmquist | first3 = E. | authorlink3 = | last4 = Frisén | first4 = L. | authorlink4 = | last5 = Badr | first5 = G. | authorlink5 = | last6 = Andersson | first6 = M. | authorlink6 = | last7 = Vahlne | first7 = A. | last8 = Andersen | first8 = O. | date = Mar 1996 | title = Acyclovir treatment of relapsing-remitting multiple sclerosis. A randomized, placebo-controlled, double-blind study | url = https://www.ncbi.nlm.nih.gov/pubmed/8936350|journal=Journal of Neurology|volume=243|issue=3 | pages = 214–224|doi=10.1007/bf00868517|issn=0340-5354|pmc=|pmid=8936350|access-date=|quote=|via=}}</ref>. [[Valacyclovir]] reduced new lesions in patients with high disease activity.<ref>{{Cite journal | last = Bech | first = E. | last2 = Lycke | first2 = J. | last3 = Gadeberg | first3 = P. | last4 = Hansen | first4 = H.J. | last5 = Malmeström | first5 = C. | last6 = Andersen | first6 = O. | last7 = Christensen | first7 = T. | last8 = Ekholm | first8 = S. | last9 = Haahr | first9 = S. | date = 2002-01-08 | title = A randomized, double-blind, placebo-controlled MRI study of anti-herpes virus therapy in MS | url = https://www.ncbi.nlm.nih.gov/pubmed/11781402/|journal=Neurology|volume=58|issue=1 | pages = 31–36|doi=10.1212/wnl.58.1.31|issn=0028-3878|pmid=11781402}}</ref>
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