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Hydroxyproline
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'''Hydroxyproline''' is an [[amino acid]] and a major component of [[collagen]].<ref>{{Cite web | url=https://www.merriam-webster.com/dictionary/hydroxyproline | title = Definition of HYDROXYPROLINE|website=Merrian-Webster Dictionary|language=en|access-date=2019-11-26}}</ref> The formation of hydroxyproline is catalyzed via the enzyme [[procollagen-proline dioxygenase]] via a reaction that requires [[vitamin C]].{{Citation needed|reason= | date = 26 November 2019}} ==High plasma hydroxyproline== Elevated plasma hydroxyproline is associated with increased risk of [[connective tissue]] injuries<ref>{{Cite journal | last = Murguia | first = M.J. | last2 = Vailas | first2 = A. | last3 = Mandelbaum | first3 = B. | last4 = Norton | first4 = J. | last5 = Hodgdon | first5 = J. | last6 = Goforth | first6 = H. | last7 = Riedy | first7 = M. | date = 1988-11-01 | title = Elevated plasma hydroxyproline: A possible risk factor associated with connective tissue injuries during overuse | url = https://doi.org/10.1177/036354658801600619|journal=The American Journal of Sports Medicine|language=en|volume=16|issue=6 | pages = 660–664|doi=10.1177/036354658801600619|issn=0363-5465}}</ref> and metabolic bone diseases, e.g. [[osteoporosis]].<ref name="Mazzuoli1985">{{Cite journal | last = Mazzuoli | first = G. | last2 = Antonelli | first2 = R. | last3 = Minisola | first3 = S. | date = Sep 1985 | title = Clinical significance of free plasma hydroxyproline measurement in metabolic bone disease. | url = http://europepmc.org/abstract/med/4067520|journal=Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie|volume=23|issue=9 | pages = 515–519|issn=0340-076X|pmid=4067520}}</ref> ==ME/CFS== Elevated levels of hydroxyproline, a marker of collagen breakdown, was found by [[Wenzhong Xiao]] in the [[ME/CFS Severely Ill, Big Data Study]].<ref name="Xiao2018">{{Citation | last2 = Open Medicine Foundation - OMF | last = Xiao | first = Wenzhong | title = Results from the Severely Ill Patient Study (SIPS) | date = 2018-11-07 | url = https://www.youtube.com/watch?v=_N1o2gbaCl4&t=853|access-date=2019-07-16}}</ref> [[Robert Naviaux]]’s work has suggested it as a possible [[Diagnostic biomarker|biomarker]] for female [[ME/CFS]] patients.<ref name="Gordon2016">{{Cite journal | last = Gordon | first = Eric | last2 = Anderson | first2 = Wayne | last3 = Nathan | first3 = Neil | last4 = Baxter | first4 = Asha | last5 = Wang | first5 = Lin | last6 = Alaynick | first6 = William A. | last7 = Bright | first7 = A. Taylor | last8 = Li | first8 = Kefeng | last9 = Naviaux | first9 = Jane C. | date = 2016-09-13 | title = Metabolic features of chronic fatigue syndrome | url = https://www.pnas.org/content/113/37/E5472|journal=Proceedings of the National Academy of Sciences|language=en|volume=113|issue=37| pages = E5472–E5480|doi=10.1073/pnas.1607571113|issn=0027-8424|pmid=27573827}}</ref> ==Learn more == *[https://www.britannica.com/science/metabolic-bone-disease Metabolic bone disease - Encyclopedia Britannica] ==See also == *[[Amino acid]] == References == {{reflist}} [[Category:Biochemistry and cell biology]] [[Category:Amino acids]]
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