Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Immunoglobulin A
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
==ME/CFS== A study of 128 [[ME/CFS]] patients found significantly increased IgA response to [[lipopolysaccharide]]s (LPS) from the cell walls of commensal bacteria. Increased IgA response was associated with increased serum [[interleukin 1|IL-1]], [[TNFΞ±]], [[neopterin]] and elastase. The study concluded that increased translocation of commensal [[bacteria]] may be responsible for the disease activity in some ME/CFS patients.<ref name="MaesM20111002">{{Cite journal | last1 = Maes | first1 = Michael | authorlink1 = Michael Maes | last2 = Twisk | first2 = Frank N | authorlink2 = Frank Twisk | last3 = Kubera | first3 = M | authorlink3 = | last4 = Ringel | first4 = K | authorlink4 = | last5 = Leunis | first5 = JC | authorlink5 = Jean-Claude Leunis Leunis | last6 = Geffard | first6 = M | authorlink6 = | title = Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome| journal = J Affect Disord | volume = 136 | issue =3 | pages = 909-17 | date = Oct 2, 2011 | pmid = 21967891 | doi = 10.1016/j.jad.2011.09.010 | url = http://www.jad-journal.com/article/S0165-0327(11)00536-2/abstract}}</ref> Another study found elevated serum concentrations of both [[IgA]] and [[IgM]] to LPS of [[gram-negative bacteria]]. Serum IgA levels correlated with illness severity as measured by the [[FibroFatigue scale]]<ref name="MaesM20060927">{{Cite journal | last1 = Maes | first1 = Michael | authorlink1 = Michael Maes | last2 = Mihaylova | first2 = I | authorlink2 = | last3 = Leunis | first3 = JC | authorlink3 = Jean-Claude Leunis| title = Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability| journal = J Affect Disord | volume = 99 |issue = 1-3| pages = 237-40| date = Sep 27, 2006 | pmid = 17007934 | doi = 10.1016/j.jad.2006.08.021| url = http://www.jad-journal.com/article/S0165-0327%2806%2900355-7/abstract}}</ref>
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs