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Intravenous immunoglobulin
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==Notable studies related to ME/CFS== ===Positive results=== *1990, A double-blind, placebo-controlled trial of intravenous immunoglobulin therapy in patients with chronic fatigue syndrome. Done by the Department of Infectious Diseases, Prince Henry Hospital, Sydney, Australia. This study found that a low CD4 count at baseline before IVIG treatment commenced was a predictor of which ME/CFS patients would do well on IVIG.<ref name="lloyd1990" /> *1992, Immunological and psychological dysfunction in patients receiving immunotherapy for chronic fatigue syndrome<ref name="Hickie, 1992"/> *1997, Double-blind randomized controlled trial to assess the efficacy of intravenous gammaglobulin for the management of chronic fatigue syndrome in adolescents<ref name="Rowe, K, 1997"/> *1999, Five-Year Follow-Up of Young People with Chronic Fatigue Syndrome Following the Double Blind Randomised Controlled Intravenous Gammaglobulin Trial<ref name="Rowe, K, 1999"/> *2003, Successful Intravenous Immunoglobulin Therapy in 3 Cases of Parvovirus B19-Associated Chronic Fatigue Syndrome<ref name="Kerr, 2003"/> *2008, [[Tae Park]], MD, presented his study about IVIG for ME/CFS patients at the [http://www.investinme.org/IIMEC3.shtml#report 3rd Invest in ME International ME Conference]. He checked the Glomerular filtration rate (GFR) in 125 ME/CFS patients who met the [[Fukuda criteria]] by measuring s-creatinine clearance with cockcroft-auld formula. "We found there were significant renal blood flow improvements in 60 patients (50%) with IVIG treatment...the improvement of renal blood flow is between 35% and 60% of previous GFR. These findings of improved renal blood flow may be evidence of improved cerebral blood flow...[and] may explain the improvement of cognitive function and other symptoms of ME/CFS patients with IVIG treatments."<ref name="iime2008" /> * 2021, Back to the Future? Immunoglobulin Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="Brownlie2021">{{Cite journal | title = Back to the Future? Immunoglobulin Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | date = 2021-11-12 | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623195|journal=Healthcare|volume=9|issue=11|pages=1546 | last = Brownlie | first = Helen | authorlink = | last2 = Speight | first2 = Nigel | authorlink2 = Nigel Speight|doi=10.3390/healthcare9111546|pmc=PMC8623195|pmid=34828592|access-date=|issn=2227-9032|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623195 (Full text)] ===Negative results=== *1990, A controlled trial of intravenous immunoglobulin G in chronic fatigue syndrome. Done by the Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota.<ref name="peterson1990" /> *1997, Intravenous immunoglobulin is ineffective in the treatment of patients with [[chronic fatigue syndrome]]<ref>{{Cite journal | last = Vollmer-Conna | first = U | author-link = UtΓ© Vollmer-Conna | last2 = Hickie | first2 = I | last3 = Hadzi-Pavlovic | first3 = D | last4 = Tymms | first4 = K | last5 = Wakefield | first5 = D | last6 = Dwyer | first6 = J | last7 = Lloyd | first7 = A | authorlink7 = Andrew Lloyd | date = 1997 | title = Intravenous immunoglobulin is ineffective in the treatment of patients with chronic fatigue syndrome | url = http://dx.doi.org/10.1016/S0002-9343(97)90045-0|journal=American Journal of Medicine|volume=103|pages = 38-43 |doi=10.1016/S0002-9343(97)90045-0|via=}}</ref> *2015, [http://www.journalofclinicalvirology.com/article/S1386-6532(14)00447-8/abstract Paradoxical response to intravenous immunoglobulin in a case of Parvovirus B19-associated chronic fatigue syndrome], Attard, Luciano et al.Journal of Clinical Virology , Volume 62 , 54 - 57
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