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Jarred Younger
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[[File:Younger.jpg|200px|right]] '''Jarred W. Younger''' B.A. PhD. is an American researcher who leads the Neuroinflammation, Pain and Fatigue lab at the University of Birmingham, Alabama, [[United States]].<ref name="uab-profile">https://www.uab.edu/cas/psychology/people/faculty/jarred-younger</ref> He previously worked at the [[Stanford ME/CFS Initiative]] with [[Jose Montoya]], as an Assistant Professor involved in a notable study highlighting [[leptin]] levels and [[ME/CFS]].<ref name="stanfordleptin" /><ref name="pandoravideo">{{Cite web | title = Pandora Research Report: Jarred Younger - Leptin in the Role of Neuroinflammation, Pain and Fatigue | date = Jan 24, 2015 | url = https://www.youtube.com/watch?v=bFwAyrb5p34|language=en|access-date=2019-09-12}}</ref> He is currently funded by the U.S. [[National Institutes of Health]] and Department of Defense to study new techniques for diagnosing and treating [[neuroinflammation]] in ME/CFS, [[fibromyalgia]] and [[Gulf War Illness]]. In particular his work focuses on the role of [[microglia]]. ==Awards== *2016 [[Ramsay Award]] Program grant recipient, sponsored by the [[Solve ME/CFS Initiative]] for Advanced Non-Invasive Analysis in ME/CFS Diagnosis and Treatment Decisions<ref>{{Cite web | url = https://solvecfs.org/2016-ramsay-award-program-results/ | title = 2016 Ramsay Award Program Results|website=Solve ME/CFS Initiative|language=en-US|access-date=2019-09-12}}</ref><ref>{{Cite web | url = https://solvecfs.org/advanced-non-invasive-analysis-in-mecfs-diagnosis-and-treatment-decisions/ | title = Advanced Non-Invasive Analysis in ME/CFS Diagnosis and Treatment Decisions | date = 2016-12-07 | website = Solve ME/CFS Initiative|language=en-US|access-date=2020-02-18}}</ref> ==Committees and boards== ===ME/CFS Collaborative Research Center=== Dr. Younger is a member of the Working Group which offers their expertise and resources to the [[ME/CFS Collaborative Research Center at Stanford University]].<ref>{{Cite web | url = https://bos.etapestry.com/prod/viewEmailAsPage.do?erRef=773.0.423082047&databaseId=OMF&mailingId=34274682&jobRef=773.0.506425459&key=b6b9237b3ebd1e462a5d11dbc5c4dae&personaRef=773.0.423082048&memberId=1348639685 | title = OMF grants $1.2M to Ramp Up Collaborative Research Center at Stanford University|website=bos.etapestry.com|access-date=2019-09-12}}</ref> ===ME/CFS Common Data Element (CDE) Project=== Chair (Overall/Cognitive) of the Neurologic/Cognitive/CNS Imaging Working Group of the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Common Data Element (CDE) Project sponsored by the [[National Institute of Neurological Disorders and Stroke]] (NINDS) and the [[Centers for Disease Control and Prevention]] (CDC).<ref>{{Cite web | url = https://www.commondataelements.ninds.nih.gov/Myalgic%20Encephalomyelitis/Chronic%20Fatigue%20Syndrome#pane-138 | title = Complete Myalgic Encephalomyelitis/Chronic Fatigue Syndrome CDE Roster | last = | first = | authorlink = | date = | website = NIH|archive-url=|archive-date=|access-date=2019-10-11}}</ref> ==Notable studies== *2010, [[Low dose naltrexone]] for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels<ref name="Younger2013">{{Cite journal | last = Younger | first = Jarred | authorlink = Jarred Younger | last2 = Noor | first2 = Noorulain | authorlink2 = | last3 = McCue | first3 = Rebecca | authorlink3 = | last4 = Mackey | first4 = Sean | authorlink4 = | date = Feb 2013 | title = Low-dose naltrexone for the treatment of fibromyalgia: Findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels | url = http://doi.wiley.com/10.1002/art.37734|journal=Arthritis & Rheumatism|language=en|volume=65|issue=2 | pages = 529β538|doi=10.1002/art.37734|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://onlinelibrary.wiley.com/doi/pdf/10.1002/art.37734 (Full Text)] *2009, Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study<ref name="Younger2009">{{Cite journal | last = Younger | first = Jarred | authorlink = Jarred Younger | last2 = Mackey | first2 = Sean | authorlink2 = | date = May 2009 | title = Fibromyalgia Symptoms Are Reduced by Low-Dose Naltrexone: A Pilot Study | url = https://academic.oup.com/painmedicine/article-lookup/doi/10.1111/j.1526-4637.2009.00613.x|journal=Pain Medicine|language=en|volume=10|issue=4 | pages = 663β672|doi=10.1111/j.1526-4637.2009.00613.x|issn=1526-2375|pmc=2891387|pmid=19453963|access-date=|quote=|via=}}</ref> - [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891387/ (Full Text)] *2013, Daily cytokine fluctuations, driven by [[leptin]], are associated with fatigue severity in [[chronic fatigue syndrome]]: Evidence of inflammatory pathology<ref name="stanfordleptin">{{Cite journal | last1 = Stringer | first1 = EA | last2 = Baker | first2 = KS | last3 = Carrol | first3 = IR | last4 =Montoya | first4 = JG | authorlink4 = Jose Montoya | last5 = Chu | first5 = L | authorlink5 = Lily Chu | last6 = Maeker | first6 = HT | last7 = Younger | first7 = JW | authorlink7 = Jarred Younger| title = Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: Evidence of inflammatory pathology | journal = J Transl Med.| date = Apr 9, 2013 | pmid = 23570606 | pmc = 3637529 | doi = 10.1186/1479-5876-11-93| url = http://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-11-93 }}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637529/ (Full Text)] *2017, Cytokine signature associated with disease severity in chronic fatigue syndrome patients<ref name="Montoya, 2017">{{Cite journal | last1 = Montoya | first1 = Jose G. | authorlink1 = Jose Montoya | last2 = Holmes | first2 = Tyson H. | authorlink2 = | last3 = Anderson | first3 = Jill N. | authorlink3 = | last4 =Maecker | first4 = Holden T. | authorlink4 = | last5 = Rosenberg-Hasson | first5 = Yael | authorlink5 = | last6 = Valencia | first6 = Ian J. | authorlink6 = Ian Valencia | last7 = Chu | first7 = Lily | authorlink7 = Lily Chu | last8 = Younger | first8 = Jarred W. | authorlink8 = Jarred Younger | last9 =Tato | first9 = Cristina M. | authorlink9 = | last10 = Davis | first10 = Mark M. | authorlink10 = Mark Davis| title = Cytokine signature associated with disease severity in chronic fatigue syndrome patients| journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 114 | issue = 34 | page = E7150-E7158| date = 2017 | pmid = | doi = 10.1073/pnas.1710519114 }}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576836/ (Full Text)] *2019, Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy<ref name="Meuller2019">{{Cite journal | last = Mueller | first = Christina | authorlink = | last2 = Lin | first2 = Joanne C. | authorlink2 = | last3 = Sheriff | first3 = Sulaiman | authorlink3 = | last4 = Maudsley | first4 = Andrew A. | authorlink4 = | last5 = Younger | first5 = Jarred W. | authorlink5 = Jarred Younger | date = 2019-01-07 | title = Evidence of widespread metabolite abnormalities in Myalgic encephalomyelitis/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy | url = http://link.springer.com/10.1007/s11682-018-0029-4|journal=Brain Imaging and Behavior|language=en|volume=|issue=|pages=|doi=10.1007/s11682-018-0029-4|issn=1931-7557|quote=|via=}}</ref> - [[pubmed:30617782|(Abstract)]] ==Talks and interviews== *2011, [https://www.youtube.com/watch?v=ma_lY7NFLQk Chronic Pain in Women] *2014, [https://www.youtube.com/watch?v=NoGfOsrarlY ME/CFS Alerts Episode 68: Jarred Younger Interviewed by Deborah Waroff] *2015, [https://www.youtube.com/watch?v=TOqBYZg6Nmo Dr Jarred Younger - LDN Scientist - Low Dose Naltrexone] *2015, [https://www.youtube.com/watch?v=bFwAyrb5p34 Pandora Research Report: Jarred Younger - Leptin in the Role of Neuroinflammation, Pain and Fatigue] (see [[Leptin]]) *2015, [https://www.youtube.com/watch?v=TH_upgDgLQ8 Jarred Younger, Ph.D. - Microglial Modulation in the Treatment of Fibromyalgia] *2015, [[Spoonie Radio]] [https://www.youtube.com/watch?v=9UqkB6TBQ-A Ep 15: Jarred Younger] (see also [[Courtney Craig]]) *2016, [https://www.youtube.com/watch?v=wJB95m4FLa0 Chronic Fatigue Syndrome & Myalgic Encephalomyelitis: Can We Find Answers in the Brain? - Solve CFS Webinar] *2016, [https://www.youtube.com/channel/UCoVoOvIX90IMEZCbBf_ycEA Younger Lab YouTube Channel: Series of ongoing talks on the work of the lab] *2016, [http://selfhacked.com/2016/03/29/dr-jared-younger-cutting-edge-research-on-cfs-neuroinflammation-pain-and-fatigue/ Dr. Jarred Younger: Cutting Edge Research on CFS, Neuroinflammation, Pain, and Fatigue] * 2018, [https://www.youtube.com/watch?v=rxdzaWD5wfU ME/CFS Involves Brain Inflammation: Results from a Ramsay Pilot Study]<ref>{{Cite web | url = https://www.youtube.com/watch?v=rxdzaWD5wfU | title = ME/CFS Involves Brain Inflammation: Results from a Ramsay Pilot Study | date = Dec 14, 2018|access-date=|website=YouTube | last = | first = | authorlink = Jarred Younger|archive-url=|archive-date=|publisher=SolveCFS}}</ref> * 29 Sep 2018, ''How Brain Inflammation Causes ME/CFS'', given at Second Annual [[Community Symposium on the Molecular Basis of ME/CFS - 2017|Community Symposium on the Molecular Basis of ME/CFS]], sponsored by [[Open Medicine Foundation]] - [https://www.youtube.com/watch?v=8XrdSlpUQTE&list=PLl4AfLZNZEQPxjqF4ojAO3wdCFMeriNBK&index=14 (Video)] *2019, [https://www.youtube.com/watch?v=JW-JYCcAnUg Dr. Jarred Younger - Neuroinflammation in ME/CFS] *2022, [https://www.youtube.com/results?search_query=solve+me%2Fcfs+jarred+younger+june+23 Dr. Jarred Younger Presents: How We Can See ME/CFS Inflammation in the Brain - Solve ME Webinar] ==Articles and blogs== *2015, [http://www.cortjohnson.org/blog/2015/07/15/the-neuroinflammation-man-jarred-younger-on-inflammation-fibromyalgia-and-chronic-fatigue-syndrome/ The Neuroinflammation Man: Jarred Younger on Inflammation, Fibromyalgia and Chronic Fatigue Syndrome] ([[Cort Johnson]]) *2015, [http://www.cortjohnson.org/blog/2015/01/09/younger-chronic-fatigue-fibromyalgia-lab/ New Chronic Fatigue Syndrome and Fibromyalgia Lab Opens: Jarred Younger Talks] (Cort Johnson) *2016, [http://www.uab.edu/uabmagazine/features/prisoners-of-pain Prisoners of Pain - UAB magazine (Spring 2016)] *2016, [https://selfhacked.com/2016/03/29/dr-jared-younger-cutting-edge-research-on-cfs-neuroinflammation-pain-and-fatigue/ Self Hacked on Dr Younger] *2016, [https://www.youtube.com/channel/UCoVoOvIX90IMEZCbBf_ycEA/ Younger Lab YouTube Channel] *2016, [http://www.cortjohnson.org/blog/2016/03/08/fibromyalgia-chronic-fatigue-syndrome-neuroinflammation-pain-fatigue-lab-makes-good/ Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS) Research Center Makes Good] (Cort Johnson) *2018, [https://www.healthrising.org/blog/2018/09/24/brain-fire-neuroinflammation-found-chronic-fatigue-syndrome-me-cfs/ Brain on Fire: Widespread Neuroinflammation Found in Chronic Fatigue Syndrome (ME/CFS)](Cort Johnson) <blockquote>Younger's new approach looked at the entire [[brain]] and found signs of [[inflammation]] almost everywhere. When asked what could cause that, Younger said that any neurodegenerative/ neuroinflammatory disorder like [[Multiple sclerosis|MS]] or a severe brain injury that tweaks the [[microglia]] (immune cells in the brain) enough to produce a sustained period of inflammation, burns up the [[oxygen]] in the system. Once that happens, the cells resort to [[anaerobic metabolism]] and lactate builds up just as it does in the [[Muscle|muscles]] during [[exercise]].</blockquote> ==See also== *[[Fibromyalgia]] *[[Gulf War Illness]] *[[Chronic fatigue syndrome]] *[[Leptin]] *[[Low dose naltrexone]] *[[Microglia]] *[[Neuroinflammation]] ==Learn more== *[https://www.ncbi.nlm.nih.gov/pubmed/?term=Younger%20J%5BAuthor%5D&cauthor=true&cauthor_uid=24526250 Publications on the PubMed register - Jarred Younger] *[https://sites.uab.edu/younger/ UAB Departmental Website] *[https://www.uab.edu/cas/psychology/people/faculty/jarred-younger Biography at UAB] *[https://www.facebook.com/Neuroinflammation-Pain-and-Fatigue-Laboratory-at-UAB-1543963919214695/ Facebook page for Younger Lab at UAB] ==References== {{Reflist}} [[Category:Researchers]] [[Category:US researchers]]
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