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List of abnormal findings in chronic fatigue syndrome and myalgic encephalomyelitis
(section)
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=== Cellular respiration === * abnormalities in [[cellular respiration]] including a reduction in [[glycolysis]],<ref>{{Cite journal | last = Armstrong | first = Christopher W. | last2 = McGregor | first2 = Neil R. | last3 = Lewis | first3 = Donald P. | last4 = Butt | first4 = Henry L. | last5 = Gooley | first5 = Paul R. | date = 2015-05-30 | title = Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients|url=https://link.springer.com/article/10.1007/s11306-015-0816-5 | journal=Metabolomics|language=en | volume=11 | issue=6 | pages=1626–1639 | doi=10.1007/s11306-015-0816-5 | issn=1573-3882}}</ref> including impaired [[pyruvate dehydrogenase]]<ref>{{Cite journal | last = Fluge | first = Øystein | last2 = Mella | first2 = Olav | last3 = Bruland | first3 = Ove | last4 = Risa | first4 = Kristin | last5 = Dyrstad | first5 = Sissel E. | last6 = Alme | first6 = Kine | last7 = Rekeland | first7 = Ingrid G. | last8 = Sapkota | first8 = Dipak | last9 = Røsland | first9 = Gro V. | date = 2016-12-22 | title = Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/28018972 | journal=JCI insight|volume=1 | issue=21 | pages = e89376 | doi=10.1172/jci.insight.89376 | issn=2379-3708 | pmc=5161229 | pmid=28018972}}</ref> * increased [[lactic acid]]<ref name="Plioplys1995">{{cite journal | last1 = Plioplys | first1 = AV | authorlink1 = | last2 = Plioplys | first2 = S | authorlink2 = | title = Serum levels of carnitine in chronic fatigue syndrome: clinical correlates | journal = Neuropsychobiology | date = 1995 | volume = 32 | issue = 3 | pages = 132-8 | pmid = 8544970 | url = http://www.ncbi.nlm.nih.gov/pubmed/8544970 }}</ref><ref name="LaneRJ1998">{{cite journal | last1 = Lane | first1 = RJ | authorlink1 = | last2 = Barrett | first2 = MC | authorlink2 = Michael Barrett | last3 = Taylor | first3 = DJ | authorlink3 = Doris Taylor | last4 = Kemp | first4 = GJ | authorlink4 = Graham Kemp | last5 = Lodi | first5 = R | authorlink5 = Raffaele Lodi | title = Heterogeneity in chronic fatigue syndrome: evidence from magnetic resonance spectroscopy of muscle | journal = Neuromuscul Disord | volume = 8 | issue = 3-4 | pages = 204-9 | date = May 1998 | pmid = 9631403 | url = http://www.ncbi.nlm.nih.gov/pubmed/9631403 }}</ref><ref name="JonesDE2010">{{cite journal | last1 = Jones | first1 = David EJ | authorlink1 = | last2 = Hollingsworth | first2 = Kieren G | authorlink2 = Kieren Hollingsworth | last3 = Taylor | first3 = Renee R | authorlink3 = Renee Taylor | last4 = Blamire | first4 = Andrew M | authorlink4 = Andrew Blamire | last5 = Newton | first5 = Julia L | authorlink5 = Julia Newton | title = Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome | journal = J Intern Med | volume = 267 | issue = 4 | pages = 394-401 | date = Apr 2010 | pmid = 20433583 | doi = 10.1111/j.1365-2796.2009.02160.x | url = http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2009.02160.x/abstract }}</ref><ref name="LengertN2015">{{cite journal | last1 = Lengert | first1 = Nicor | authorlink1 = Nicor Lengert | last2 = Drossel | first2 = Barbara | authorlink2 = Barbara Drossel | title = In silico analysis of exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome | journal = Biophysical Chemistry | volume = 202 | pages = 21–31 | date = Jul 2015 | pmid = 25899994 | doi = 10.1016/j.bpc.2015.03.009 | url = http://www.sciencedirect.com/science/article/pii/S0301462215000630 }}</ref><ref name="Mathew2009"/> * reduction in metabolites reflecting a slowed metabolism<ref>{{Cite journal | last = Naviaux | first = Robert K. | authorlink1 = Robert Naviaux | last2 = Naviaux | first2 = Jane C. | last3 = Li | first3 = Kefeng | last4 = Bright | first4 = A. Taylor | last5 = Alaynick | first5 = William A. | last6 = Wang | first6 = Lin | last7 = Baxter | first7 = Asha | last8 = Nathan | first8 = Neil | last9 = Anderson | first9 = Wayne | date = 2016-09-13 | title = Metabolic features of chronic fatigue syndrome|url=http://www.pnas.org/content/113/37/E5472 | journal=Proceedings of the National Academy of Sciences|language=en | volume=113 | issue=37 | pages = E5472–E5480 | doi=10.1073/pnas.1607571113 | issn=0027-8424 | pmid=27573827}}</ref> *analysis of peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction, supporting a model...that would suggest an elevation of oxidative stress.<ref name="Sweetman2020" />
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