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Loratadine
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'''Loratadine''' or '''Claritin''' is H1 receptor antagonist which is commonly used as a non-sedating anti-histamine.<ref name="medscape">{{Cite web|url=http://www.medscape.com/viewarticle/893858 | title = Mast Cell Activation May Underlie 'Chronic Fatigue Syndrome' | last = Tucker | first = Miriam E. | authorlink = | date = March 13, 2018 | website = Medscape|archive-url=|archive-date=|url-status=|access-date=2019-07-30}}</ref><ref name="TMS-meds">{{Cite web|url=https://tmsforacure.org/treatments-2/medications-treat-mast-cell-diseases/ | title = Medications to Treat Mast Cell Diseases|last = | first = | authorlink = | date = | website = The Mast Cell Disease Society|language=en-US|archive-url=|archive-date=|url-status=|access-date=2021-02-16}}</ref><ref name="drugscom">{{Cite web|url=https://drugs.com/loratadine.html | title = Loratadine|last = | first = | authorlink = |website=drugs.com|language=en-US|archive-url=|archive-date=|url-status=|access-date=2021-02-17}}</ref> It is a potential treatment for [[mast cell activation syndrome]] (MCAS).<ref name="medscape" /><ref name="TMS-meds">{{Cite web|url=https://tmsforacure.org/treatments-2/medications-treat-mast-cell-diseases/ | title = Medications to Treat Mast Cell Diseases|last = | first = | authorlink = | date = | website = The Mast Cell Disease Society|language=en-US|archive-url=|archive-date=|url-status=|access-date=2021-02-16}}</ref> Loratadine is sometimes misspelled as ''Loratidine''.<ref name=TMS-meds /> ==Theory == ==Evidence == ===MCAS and ME/CFS=== The March 2 and 3, 2018, physicians summit in Salt Lake City, Utah addressed the potential role of MCAS treatment in ME/CFS treatment.<ref name="medscape" /> Several physicians remarked on the relatively high prevalence of MCAS in their ME/CFS patients (making estimating of roughly half their patients) and its significance in pointing toward treatment of symptoms associated with ME/CFS. Dr. [[Susan Levine]] suggested that while MCAS likely only affects a subset of ME/CFS patients, for those it does, it can manifest as inability to tolerate certain foods or medications and "If we can reduce the mast cell problem, we can facilitate taking other drugs to treat ME/CFS."<ref name="medscape" /> ===Long COVID === Loratadine has limited evidence for use in [[Long COVID]] patients from a small observational study by Glynne et al. (2022).<ref name="Glynne2022"/> ==Side effects == ==Costs and availability == ==Notable studies == *2022, Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines<ref name="Glynne2022">{{Cite journal | title = Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines | date = Jan 2022|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494538/|journal=Journal of Investigative Medicine|volume=70|issue=1 | pages = 61β67|last = Glynne | first = Paul | authorlink = Paul Glynne | last2 = Tahmasebi | first2 = Natasha | authorlink2 = | last3 = Gant | first3 = Vanya | authorlink3 = | last4 = Gupta | first4 = Rajeev | authorlink4 = |doi=10.1136/jim-2021-002051|pmc=8494538|pmid=34611034|access-date=|issn=1081-5589|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494538/ (Full text)] ==Learn more == *[https://tmsforacure.org/treatments-2/medications-treat-mast-cell-diseases/ Medications to Treat Mast Cell Diseases] - The Mast Cell Disease Society *[https://www.drugs.com/Loratadine.html Loratadine] - drugs.com ==See also == *[[Long COVID]] *[[Histamine]] *[[Mast cell activation syndrome]] *[[Mast cell activation disorder]] ==References== {{reflist}} [[Category:Potential treatments]] [[Category:Antihistamines]] [[Category:H1 antihistamines]] [[Category:Non-sedating antihistamines]]
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