Martin Pall: Difference between revisions
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[[File:Martin Pall.png | [[File:Martin Pall.png|right]] | ||
'''Martin L. Pall,''' PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A.<ref> | '''Martin L. Pall,''' PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A.<ref>{{Cite web|url=https://smb.wsu.edu/faculty-trainees-and-staff/faculty|title=Faculty|website=SMB|language=en|access-date=2020-03-02}}</ref> He states that he developed [[Chronic Fatigue Syndrome]] (CFS) from a [[varicella zoster virus]] infection in the later 1990s but has made a full recovery by following a program of avoiding exercise, diet changes, and taking supplements that decrease inflammation.<ref>{{Cite web|url=https://www.prohealth.com/library/live-chat-with-martin-l-pall-phd-july-6-2007-professor-of-biochemistry-explains-mechanisms-of-chronic-fatigue-syndrome-and-fibromyalgia-suggested-protocol-24432|title=Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia & Suggested Protocol|last=July 9|first=ProHealth com •|last2=2007|date=2007-07-09|website=Prohealth|language=en-US|access-date=2020-03-02}}</ref> | ||
Dr. Pall was one of the authors of the 2011 case definition, the [[International Consensus Criteria]].<ref>{{Cite journal|last=Carruthers|first=Bruce M.|author-link=Bruce Carruthers|last2=van de Sande|first2=Marjorie I.|author-link2=Marjorie van de Sande|last3=De Meirleir|first3=Kenny L.|author-link3=Kenny De Meirleir|last4=Klimas|first4=Nancy G.|author-link4=Nancy Klimas|last5=Broderick|first5=Gordon|author-link5=Gordon Broderick|last6=Mitchell|first6=Terry|author-link6=Terry Mitchell|last7=Staines|first7=Donald|author-link7=Donald Staines|last8=Powles|first8=A. C. Peter|author-link8=A C Peter Powles|last9=Speight|first9=Nigel|author-link9=Nigel Speight|last10=Vallings|first10=Rosamund|author-link10=Rosamund Vallings|last11=Bateman|first11=Lucinda|author-link11=Lucinda Bateman|last12=Baumgarten-Austrheim|first12=Barbara|author-link12=Barbara Baumgarten-Austrheim|last13=Bell|first13=David|author-link13=David Bell|last14=Carlo-Stella|first14=Nicoletta|author-link14=Nicoletta Carlo-Stella|last15=Chia|first15=John|author-link15=John Chia|last16=Darragh|first16=Austin|author-link16=Austin Darragh|last17=Jo|first17=Daehyun|author-link17=Daehyun Jo|last18=Lewis|first18=Donald|author-link18=Donald Lewis|last19=Light|first19=Alan|author-link19=Alan Light|last20=Marshall-Gradisnik|first20=Sonya|author-link20=Sonya Marshall-Gradisnik|last21=Mena|first21=Ismael|author-link21=Ismael Mena|last22=Mikovits|first22=Judy|author-link22=Judy Mikovits|last23=Miwa|first23=Kunihisa|author-link23=Kunihisa Miwa|last24=Murovska|first24=Modra|author-link24=Modra Murovska|last25=Pall|first25=Martin|author-link25=Martin Pall|last26=Stevens|first26=Staci|author-link26=Staci Stevens|date=2011-08-22|title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> | Dr. Pall was one of the authors of the 2011 case definition, the [[International Consensus Criteria]].<ref>{{Cite journal|last=Carruthers|first=Bruce M.|author-link=Bruce Carruthers|last2=van de Sande|first2=Marjorie I.|author-link2=Marjorie van de Sande|last3=De Meirleir|first3=Kenny L.|author-link3=Kenny De Meirleir|last4=Klimas|first4=Nancy G.|author-link4=Nancy Klimas|last5=Broderick|first5=Gordon|author-link5=Gordon Broderick|last6=Mitchell|first6=Terry|author-link6=Terry Mitchell|last7=Staines|first7=Donald|author-link7=Donald Staines|last8=Powles|first8=A. C. Peter|author-link8=A C Peter Powles|last9=Speight|first9=Nigel|author-link9=Nigel Speight|last10=Vallings|first10=Rosamund|author-link10=Rosamund Vallings|last11=Bateman|first11=Lucinda|author-link11=Lucinda Bateman|last12=Baumgarten-Austrheim|first12=Barbara|author-link12=Barbara Baumgarten-Austrheim|last13=Bell|first13=David|author-link13=David Bell|last14=Carlo-Stella|first14=Nicoletta|author-link14=Nicoletta Carlo-Stella|last15=Chia|first15=John|author-link15=John Chia|last16=Darragh|first16=Austin|author-link16=Austin Darragh|last17=Jo|first17=Daehyun|author-link17=Daehyun Jo|last18=Lewis|first18=Donald|author-link18=Donald Lewis|last19=Light|first19=Alan|author-link19=Alan Light|last20=Marshall-Gradisnik|first20=Sonya|author-link20=Sonya Marshall-Gradisnik|last21=Mena|first21=Ismael|author-link21=Ismael Mena|last22=Mikovits|first22=Judy|author-link22=Judy Mikovits|last23=Miwa|first23=Kunihisa|author-link23=Kunihisa Miwa|last24=Murovska|first24=Modra|author-link24=Modra Murovska|last25=Pall|first25=Martin|author-link25=Martin Pall|last26=Stevens|first26=Staci|author-link26=Staci Stevens|date=2011-08-22|title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> | ||
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==NO/ONOO-cycle== | ==NO/ONOO-cycle== | ||
Dr. Pall developed the [[Nitric oxide hypothesis | Nitric Oxide Cycle Theory]], also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in [[chronic fatigue syndrome]]/[[myalgic encephalomyelitis]] (CFS/ME), [[Multiple Chemical Sensitivity]] (MCS), [[fibromyalgia]] (FM) and possibly a large number of other chronic inflammatory diseases such as heart disease. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.<ref> | Dr. Pall developed the [[Nitric oxide hypothesis | Nitric Oxide Cycle Theory]], also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in [[chronic fatigue syndrome]]/[[myalgic encephalomyelitis]] (CFS/ME), [[Multiple Chemical Sensitivity]] (MCS), [[fibromyalgia]] (FM) and possibly a large number of other chronic inflammatory diseases such as heart disease. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.<ref>{{Cite web|url=https://www.prohealth.com/library/nitric-oxide-cycle-theory-will-it-explain-cfs-fm-and-other-unexplained-illnesses-qa-with-martin-l-pall-phd-24338|title=Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD|date=2007-06-22|website=Prohealth|language=en-US|access-date=2020-03-02}}</ref> | ||
He believes that certain over-the-counter supplements, such as [[fish oil]], [[CoQ10]], [[vitamin E]], NAC ([[N-acetylcysteine]]), [[magnesium]], and other [[antioxidants]], can help downregulate the oxidation caused by the nitric oxide cycle.<ref> | He believes that certain over-the-counter supplements, such as [[fish oil]], [[CoQ10]], [[vitamin E]], NAC ([[N-acetylcysteine]]), [[magnesium]], and other [[antioxidants]], can help downregulate the oxidation caused by the nitric oxide cycle.<ref>{{Cite web|url=https://www.prohealth.com/library/antioxidant-suggestions-for-down-regulation-of-the-no-onoo-cycle-from-dr-martin-pall-phd-28465|title=Antioxidant Suggestions For Down-regulation of the NO/ONOO- Cycle from Dr. Martin Pall, PhD|last=Pall|first=Martin L.|last2=June 12|first2=PhD • ProHealth com •|date=2007-06-12|website=Prohealth|language=en-US|access-date=2020-03-02|last3=2007}}</ref> He believes [[Vitamin B12]] injections can also be a potent nitric oxide scavenger.<ref name=":0">{{Cite web|url=http://www.investinme.org/IIMEC2.shtml|title=Invest in ME Research - IIMEC2|website=www.investinme.org|access-date=2020-03-02}}</ref> | ||
==Book== | ==Book== | ||
*2007, ''[[Explaining "Unexplained Illnesses"|Explaining "Unexplained Illnesses": Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome]]''<ref | *2007, ''[[Explaining "Unexplained Illnesses"|Explaining "Unexplained Illnesses": Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome]]''<ref>{{Cite book|title=Explaining "unexplained illnesses" : disease paradigm for chronic fatigue syndrome, multiple chemical sensitivity, fibromyalgia, post-traumatic stress disorder, Gulf War syndrome, and others|isbn=978-0-7890-2388-9|url=https://www.worldcat.org/oclc/73993843|date=2007|publisher=Harrington Park Press|last=Pall, Martin L.|oclc=73993843|location=New York}}</ref> | ||
==Articles== | ==Articles== | ||
*2007, [http://www.prohealth.com//library/showArticle.cfm?libid=12896''Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD''] | *2007, [http://www.prohealth.com//library/showArticle.cfm?libid=12896 ''Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD''] | ||
*2009, [http://www.prohealth.com/library/showarticle.cfm?libid=14467 ''Dr. Pall Debuts Website on 'Tenth-Paradigm' Diseases Including FM, ME/CFS, and MCS''] | *2009, [http://www.prohealth.com/library/showarticle.cfm?libid=14467 ''Dr. Pall Debuts Website on 'Tenth-Paradigm' Diseases Including FM, ME/CFS, and MCS''] | ||
*2010, [http://www.townsendletter.com/FebMarch2010/cureNO0210.html ''How Can We Cure NO/ONOO− Cycle Diseases? Approaches to Curing Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Fibromyalgia, Multiple Chemical Sensitivity, Gulf War Syndrome and Possibly Many Others" by Martin Pall in Townsend Letter] | *2010, [http://www.townsendletter.com/FebMarch2010/cureNO0210.html ''How Can We Cure NO/ONOO− Cycle Diseases? Approaches to Curing Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Fibromyalgia, Multiple Chemical Sensitivity, Gulf War Syndrome and Possibly Many Others" by Martin Pall in Townsend Letter''] | ||
==Talks and interviews== | ==Talks and interviews== | ||
*2007, [http://www.prohealth.com/library/showarticle.cfm?libid=12966 "Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia & Suggested Protocol"] | *2007, [http://www.prohealth.com/library/showarticle.cfm?libid=12966 "Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia & Suggested Protocol"] | ||
*2007, Speaker at the 2nd [[Invest in ME International ME Conference]] - ''Biochemical Underpinnings of ME/CFS''<ref | *2007, Speaker at the 2nd [[Invest in ME International ME Conference]] - ''Biochemical Underpinnings of ME/CFS'' <ref name=":0" /> - [https://www.youtube.com/watch?v=cDwaj56n2UU (Video)] | ||
*2014, [https://www.youtube.com/watch?v=3kQQyU8NHv8 Martin Pall explains "Unexplained Illnesses"] (English with French subtitles) | *2014, [https://www.youtube.com/watch?v=3kQQyU8NHv8 Martin Pall explains "Unexplained Illnesses"] (English with French subtitles) | ||
==Publications on ME/CFS== | ==Publications on ME/CFS== | ||
*2000, Elevated, sustained peroxynitrite levels as the cause of [[chronic fatigue syndrome]] | *2000, Elevated, sustained peroxynitrite levels as the cause of [[chronic fatigue syndrome]]<ref>{{Cite journal|last=Pall|first=M.L.|author-link=Martin Pall|last2=|first2=|author-link2=|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=Jan 2000|title=Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome|url=https://linkinghub.elsevier.com/retrieve/pii/S0306987798908258|journal=Medical Hypotheses|language=en|volume=54|issue=1|pages=115–125|doi=10.1054/mehy.1998.0825|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [[pubmed:10790736|(Abstract)]] | ||
*Elevated Peroxynitrite as the Cause of [[Chronic Fatigue Syndrome]]: Other Inducers and Mechanisms of Symptom Generation<ref | *Elevated Peroxynitrite as the Cause of [[Chronic Fatigue Syndrome]]: Other Inducers and Mechanisms of Symptom Generation<ref>{{Cite journal|last=Pall|first=Martin L.|author-link=Martin Pall|last2=|first2=|author-link2=|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=Jan 2000|title=Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation|url=http://www.tandfonline.com/doi/full/10.1300/J092v07n04_05|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=7|issue=4|pages=45–58|doi=10.1300/J092v07n04_05|issn=1057-3321|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.tandfonline.com/doi/abs/10.1300/J092v07n04_05 (Abstract)] | ||
*2000, [[Cobalamin]] Used in | *2000, [[Cobalamin]] Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger<ref>{{Cite journal|last=Pall|first=Martin L.|author-link=Martin Pall|last2=|first2=|author-link2=|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=Jan 2000|title=Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger|url=http://www.tandfonline.com/doi/full/10.1300/J092v08n02_04|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=8|issue=2|pages=39–44|doi=10.1300/J092v08n02_04|issn=1057-3321|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.tandfonline.com/doi/abs/10.1300/J092v08n02_04 (Abstract)] | ||
*2001, Common etiology of [[Post-traumatic stress disorder|posttraumatic stress disorder]], [[fibromyalgia]], | *2001, Common etiology of [[Post-traumatic stress disorder|posttraumatic stress disorder]], [[fibromyalgia]], chronic fatigue syndrome and [[multiple chemical sensitivity]] via elevated nitric oxide/peroxynitrite<ref>{{Cite journal|last=Pall|first=M. L.|author-link=Martin Pall|last2=|first2=|author-link2=|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=Aug 2001|title=Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite|url=https://www.ncbi.nlm.nih.gov/pubmed/11461161|journal=Medical Hypotheses|volume=57|issue=2|pages=139–145|doi=10.1054/mehy.2001.1325|issn=0306-9877|pmc=|pmid=11461161|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/11461161 (Full Text)] | ||
*2001, Elevated nitric oxide/peroxynitrite mechanism for the common etiology of [[multiple chemical sensitivity]], | *2001, Elevated nitric oxide/peroxynitrite mechanism for the common etiology of [[multiple chemical sensitivity]], chronic fatigue syndrome, and [[Post-traumatic stress disorder|posttraumatic stress disorder]]<ref>{{Cite journal|last=Pall|first=M. L.|author-link=Martin Pall|last2=Satterlee|first2=J. D.|author-link2=|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=Mar 2001|title=Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder|url=https://www.ncbi.nlm.nih.gov/pubmed/12000033|journal=Annals of the New York Academy of Sciences|volume=933|issue=|pages=323–329|doi=10.1111/j.1749-6632.2001.tb05836.x|issn=0077-8923|pmc=|pmid=12000033|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pubmed/12000033 (Abstract)] | ||
*2002, Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of | *2002, Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients<ref>{{Cite journal|last=Pall|first=Martin L.|author-link=Martin Pall|last2=|first2=|author-link2=|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=Jan 2002|title=Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients|url=http://www.tandfonline.com/doi/full/10.1300/J092v10n03_04|journal=Journal of Chronic Fatigue Syndrome|language=en|volume=10|issue=3-4|pages=37–41|doi=10.1300/J092v10n03_04|issn=1057-3321|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [http://dx.doi.org/10.1300/J092v10n03_04 (Abstract)] | ||
*2002, | *2002, Chronic fatigue syndrome/myalgic encephalitis<ref>{{Cite journal|last=Pall|first=Martin L.|author-link=Martin Pall|last2=|first2=|author-link2=|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=Sep 2002|title=Chronic fatigue syndrome/myalgic encephalitis|url=https://www.ncbi.nlm.nih.gov/pubmed/12236283|journal=The British Journal of General Practice: The Journal of the Royal College of General Practitioners|volume=52|issue=482|pages=762; author reply 763–764|doi=|issn=0960-1643|pmc=1314420|pmid=12236283|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314420/ (Full Access)] | ||
*2003, Elevated levels of protein carbonyls in sera of | *2003, Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients<ref>{{Cite journal|last=Smirnova|first=Iva V.|author-link=|last2=Pall|first2=Martin|author-link2=Martin Pall|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=2003|title=Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients|url=http://link.springer.com/10.1023/A:1024176016962|journal=Molecular and Cellular Biochemistry|volume=248|issue=1/2|pages=93–95|doi=10.1023/A:1024176016962|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [[pubmed:12870659|(Abstract)]] | ||
*2005, Nitric oxide and the etiology of [[chronic fatigue syndrome]]: giving credit where credit is due | *2005, Nitric oxide and the etiology of [[chronic fatigue syndrome]]: giving credit where credit is due<ref>Pall ML. (2005). Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due. ''Medical Hypotheses, 65'' (3):631-3. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/15936892.</ref> | ||
* 2008, Post-radiation syndrome as a NO/ONOO- cycle, | * 2008, Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease<ref>Pall, ML. (2008). Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease. ''Medical Hypotheses, 71'' (4):537-41. doi:10.1016/j.mehy.2008.05.023. Epub 2008 Jul 29. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18667279</ref> | ||
*2011, | *2011, Myalgic encephalomyelitis: [[International Consensus Criteria]]<ref>{{Cite journal|last=Carruthers|first=Bruce M.|author-link=Bruce Carruthers|last2=van de Sande|first2=Marjorie I.|author-link2=Marjorie van de Sande|last3=De Meirleir|first3=Kenny L.|author-link3=Kenny De Meirleir|last4=Klimas|first4=Nancy G.|author-link4=Nancy Klimas|last5=Broderick|first5=Gordon|author-link5=Gordon Broderick|last6=Mitchell|first6=Terry|author-link6=Terry Mitchell|last7=Staines|first7=Donald|author-link7=Donald Staines|last8=Powles|first8=A. C. Peter|author-link8=A C Peter Powles|last9=Speight|first9=Nigel|author-link9=Nigel Speight|last10=Vallings|first10=Rosamund|author-link10=Rosamund Vallings|last11=Bateman|first11=Lucinda|author-link11=Lucinda Bateman|last12=Baumgarten-Austrheim|first12=Barbara|author-link12=Barbara Baumgarten-Austrheim|last13=Bell|first13=David|author-link13=David Bell|last14=Carlo-Stella|first14=Nicoletta|author-link14=Nicoletta Carlo-Stella|last15=Chia|first15=John|author-link15=John Chia|last16=Darragh|first16=Austin|author-link16=Austin Darragh|last17=Jo|first17=Daehyun|author-link17=Daehyun Jo|last18=Lewis|first18=Donald|author-link18=Donald Lewis|last19=Light|first19=Alan|author-link19=Alan Light|last20=Marshall-Gradisnik|first20=Sonya|author-link20=Sonya Marshall-Gradisnik|last21=Mena|first21=Ismael|author-link21=Ismael Mena|last22=Mikovits|first22=Judy|author-link22=Judy Mikovits|last23=Miwa|first23=Kunihisa|author-link23=Kunihisa Miwa|last24=Murovska|first24=Modra|author-link24=Modra Murovska|last25=Pall|first25=Martin|author-link25=Martin Pall|last26=Stevens|first26=Staci|author-link26=Staci Stevens|date=2011-08-22|title=Myalgic encephalomyelitis: International Consensus Criteria|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2796.2011.02428.x|journal=Journal of Internal Medicine|language=en|volume=270|issue=4|pages=327–338|doi=10.1111/j.1365-2796.2011.02428.x|issn=0954-6820|pmc=3427890|pmid=21777306|via=}}</ref> | ||
*2011, Will [[vitamin D]] supplementation ameliorate diseases characterized by chronic inflammation and fatigue?<ref name="Höck, 2011"/> | *2011, Will [[vitamin D]] supplementation ameliorate diseases characterized by chronic inflammation and fatigue?<ref name="Höck, 2011" /> | ||
==Online presence== | ==Online presence== | ||
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==References== | ==References== | ||
<references> | <references> | ||
<ref name="Höck, 2011">{{Citation | |||
<ref name="Höck, 2011"> | |||
{{Citation | |||
| last1 = Höck | first1 = Anna Dorothea | authorlink1 = Anna Dorothea Höck | | last1 = Höck | first1 = Anna Dorothea | authorlink1 = Anna Dorothea Höck | ||
| last2 = Pall | first2 = Martin L. | authorlink2 = Martin Pall | | last2 = Pall | first2 = Martin L. | authorlink2 = Martin Pall | ||
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}} | }} | ||
</ref> | </ref> | ||
<ref name="Pall, 2000a"> | <ref name="Pall, 2000a">{{Citation | ||
{{Citation | |||
| last1 = Pall | first1 = Martin | authorlink1 = Martin Pall | | last1 = Pall | first1 = Martin | authorlink1 = Martin Pall | ||
| title = Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome | | title = Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome | ||
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}} | }} | ||
</ref> | </ref> | ||
<ref name="Pall, 2000b"> | <ref name="Pall, 2000b">{{Citation | ||
{{Citation | |||
| last1 = Pall | first1 = Martin | authorlink1 = Martin Pall | | last1 = Pall | first1 = Martin | authorlink1 = Martin Pall | ||
| title = Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger | | title = Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger | ||
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| ISBN = 978-0789023889 | | ISBN = 978-0789023889 | ||
}}</ref> | }}</ref> | ||
<ref name="Pall,ML 2000"> | <ref name="Pall,ML 2000">{{Citation | ||
{{Citation | |||
| last1 = Pall | first1 = Martin L. | authorlink1 = Martin Pall | | last1 = Pall | first1 = Martin L. | authorlink1 = Martin Pall | ||
| title = Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation | | title = Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation | ||
Revision as of 22:20, March 2, 2020
Martin L. Pall, PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A.[1] He states that he developed Chronic Fatigue Syndrome (CFS) from a varicella zoster virus infection in the later 1990s but has made a full recovery by following a program of avoiding exercise, diet changes, and taking supplements that decrease inflammation.[2]
Dr. Pall was one of the authors of the 2011 case definition, the International Consensus Criteria.[3]
Education[edit | edit source]
- 1962 - B.A., Johns Hopkins University, Baltimore, MD
- 1968 - Ph.D., California Institute of Technology, Pasadena, CA
NO/ONOO-cycle[edit | edit source]
Dr. Pall developed the Nitric Oxide Cycle Theory, also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), Multiple Chemical Sensitivity (MCS), fibromyalgia (FM) and possibly a large number of other chronic inflammatory diseases such as heart disease. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.[4]
He believes that certain over-the-counter supplements, such as fish oil, CoQ10, vitamin E, NAC (N-acetylcysteine), magnesium, and other antioxidants, can help downregulate the oxidation caused by the nitric oxide cycle.[5] He believes Vitamin B12 injections can also be a potent nitric oxide scavenger.[6]
Book[edit | edit source]
- 2007, Explaining "Unexplained Illnesses": Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome[7]
Articles[edit | edit source]
- 2007, Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD
- 2009, Dr. Pall Debuts Website on 'Tenth-Paradigm' Diseases Including FM, ME/CFS, and MCS
- 2010, How Can We Cure NO/ONOO− Cycle Diseases? Approaches to Curing Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Fibromyalgia, Multiple Chemical Sensitivity, Gulf War Syndrome and Possibly Many Others" by Martin Pall in Townsend Letter
Talks and interviews[edit | edit source]
- 2007, "Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia & Suggested Protocol"
- 2007, Speaker at the 2nd Invest in ME International ME Conference - Biochemical Underpinnings of ME/CFS [6] - (Video)
- 2014, Martin Pall explains "Unexplained Illnesses" (English with French subtitles)
Publications on ME/CFS[edit | edit source]
- 2000, Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome[8] - (Abstract)
- Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation[9] - (Abstract)
- 2000, Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger[10] - (Abstract)
- 2001, Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite[11] - (Full Text)
- 2001, Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder[12] - (Abstract)
- 2002, Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients[13] - (Abstract)
- 2002, Chronic fatigue syndrome/myalgic encephalitis[14] - (Full Access)
- 2003, Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients[15] - (Abstract)
- 2005, Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due[16]
- 2008, Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease[17]
- 2011, Myalgic encephalomyelitis: International Consensus Criteria[18]
- 2011, Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?[19]
Online presence[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- ↑ "Faculty". SMB. Retrieved March 2, 2020.
- ↑ July 9, ProHealth com •; 2007 (July 9, 2007). "Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia & Suggested Protocol". Prohealth. Retrieved March 2, 2020.CS1 maint: numeric names: authors list (link)
- ↑ Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A. C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
- ↑ "Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other 'Unexplained' Illnesses? - Q&A with Martin L. Pall, PhD". Prohealth. June 22, 2007. Retrieved March 2, 2020.
- ↑ Pall, Martin L.; June 12, PhD • ProHealth com •; 2007 (June 12, 2007). "Antioxidant Suggestions For Down-regulation of the NO/ONOO- Cycle from Dr. Martin Pall, PhD". Prohealth. Retrieved March 2, 2020.CS1 maint: numeric names: authors list (link)
- ↑ 6.0 6.1 "Invest in ME Research - IIMEC2". www.investinme.org. Retrieved March 2, 2020.
- ↑ Pall, Martin L. (2007). Explaining "unexplained illnesses" : disease paradigm for chronic fatigue syndrome, multiple chemical sensitivity, fibromyalgia, post-traumatic stress disorder, Gulf War syndrome, and others. New York: Harrington Park Press. ISBN 978-0-7890-2388-9. OCLC 73993843.
- ↑ Pall, M.L. (January 2000). "Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome". Medical Hypotheses. 54 (1): 115–125. doi:10.1054/mehy.1998.0825.
- ↑ Pall, Martin L. (January 2000). "Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation". Journal of Chronic Fatigue Syndrome. 7 (4): 45–58. doi:10.1300/J092v07n04_05. ISSN 1057-3321.
- ↑ Pall, Martin L. (January 2000). "Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger". Journal of Chronic Fatigue Syndrome. 8 (2): 39–44. doi:10.1300/J092v08n02_04. ISSN 1057-3321.
- ↑ Pall, M. L. (August 2001). "Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite". Medical Hypotheses. 57 (2): 139–145. doi:10.1054/mehy.2001.1325. ISSN 0306-9877. PMID 11461161.
- ↑ Pall, M. L.; Satterlee, J. D. (March 2001). "Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder". Annals of the New York Academy of Sciences. 933: 323–329. doi:10.1111/j.1749-6632.2001.tb05836.x. ISSN 0077-8923. PMID 12000033.
- ↑ Pall, Martin L. (January 2002). "Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients". Journal of Chronic Fatigue Syndrome. 10 (3–4): 37–41. doi:10.1300/J092v10n03_04. ISSN 1057-3321.
- ↑ Pall, Martin L. (September 2002). "Chronic fatigue syndrome/myalgic encephalitis". The British Journal of General Practice: The Journal of the Royal College of General Practitioners. 52 (482): 762, author reply 763–764. ISSN 0960-1643. PMC 1314420. PMID 12236283.
- ↑ Smirnova, Iva V.; Pall, Martin (2003). "Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients". Molecular and Cellular Biochemistry. 248 (1/2): 93–95. doi:10.1023/A:1024176016962.
- ↑ Pall ML. (2005). Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due. Medical Hypotheses, 65 (3):631-3. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/15936892.
- ↑ Pall, ML. (2008). Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease. Medical Hypotheses, 71 (4):537-41. doi:10.1016/j.mehy.2008.05.023. Epub 2008 Jul 29. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18667279
- ↑ Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A. C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
- ↑ Höck, Anna Dorothea; Pall, Martin L. (2011), "Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?", Medical Hypotheses, 76 (2): 208-13, doi:10.1016/j.mehy.2010.09.032, PMID 20980105
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