Martin Pall
Martin L. Pall, PhD, is a Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, Pullman, Washington, U.S.A.[1] He states that he developed Chronic Fatigue Syndrome (CFS) from a varicella zoster virus infection in the later 1990s but has made a full recovery by following a program of avoiding exercise, diet changes, and taking supplements that decrease inflammation.[2]
Dr. Pall was one of the authors of the 2011 case definition, the International Consensus Criteria.[3]
Education[edit | edit source]
- 1962 - B.A., Johns Hopkins University, Baltimore, MD
- 1968 - Ph.D., California Institute of Technology, Pasadena, CA
NO/ONOO-cycle[edit | edit source]
Dr. Pall developed the Nitric Oxide Cycle Theory, also, called the NO/ONOO-cycle (pronounced "no-oh-no" cycle) which states that this biochemical cycle causes the inflammation present in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), Multiple Chemical Sensitivity (MCS), fibromyalgia (FM) and possibly a large number of other chronic inflammatory diseases such as heart disease. "Nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate a biochemical vicious cycle which is the cause of illness," explains Dr. Pall.[4]
He believes that certain over-the-counter supplements, such as fish oil, CoQ10, vitamin E, NAC (N-acetylcysteine), magnesium, and other antioxidants, can help downregulate the oxidation caused by the nitric oxide cycle.[5] He believes Vitamin B12 injections can also be a potent nitric oxide scavenger.[6]
Book[edit | edit source]
- 2007, Explaining "Unexplained Illnesses": Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome[7]
Articles[edit | edit source]
- 2007, Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other ‘Unexplained’ Illnesses? - Q&A with Martin L. Pall, PhD
- 2009, Dr. Pall Debuts Website on 'Tenth-Paradigm' Diseases Including FM, ME/CFS, and MCS
- 2010, How Can We Cure NO/ONOO− Cycle Diseases? Approaches to Curing Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Fibromyalgia, Multiple Chemical Sensitivity, Gulf War Syndrome and Possibly Many Others" by Martin Pall in Townsend Letter
Talks and interviews[edit | edit source]
- 2007, "Live Chat with Martin L. Pall, PhD – July 6, 2007: Professor of Biochemistry Explains Mechanisms of Chronic Fatigue Syndrome and Fibromyalgia & Suggested Protocol"
- 2007, Speaker at the 2nd Invest in ME International ME Conference - Biochemical Underpinnings of ME/CFS[8] - DVD available
- 2014, Martin Pall explains "Unexplained Illnesses" (English with French subtitles)
Publications on ME/CFS[edit | edit source]
- 2000, Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome. [9]
- Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation[10]
- 2000, Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger [11]
- 2001, Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite.[12] (Full Text)
- 2001, Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder.[13] (Abstract)
- 2002, Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients[14] (Abstract)
- 2002, Chronic fatigue syndrome/myalgic encephalitis.[15] (Full Access)
- 2003, Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients.[16]
- 2005, Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due.[17]
- 2008, Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease.[18]
- 2011, Myalgic encephalomyelitis: International Consensus Criteria.[19]
- 2011, Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?[20]
Online presence[edit | edit source]
See also[edit | edit source]
References[edit | edit source]
- ↑ http://www.smb.wsu.edu/faculty-trainees-and-staff/faculty.
- ↑ http://www.prohealth.com/library/showarticle.cfm?libid=12966
- ↑ Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A. C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
- ↑ http://www.prohealth.com//library/showArticle.cfm?libid=12896
- ↑ http://www.prohealth.com/library/showarticle.cfm?libid=16224
- ↑ http://www.investinme.eu/IIMEC2.shtml
- ↑ Pall, Martin L. (2007), Explaining 'Unexplained Illnesses': Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, and Gulf War Syndrome (book), ISBN 978-0789023889
- ↑ http://www.investinme.eu/IIMEC2.shtml
- ↑ Pall, Martin (2000), "Elevated, sustained peroxynitrite levels as the cause of chronic fatigue syndrome", Medical Hypotheses, 54 (1): 115-125, doi:10.1054/mehy.1998.0825, PMID 10790736
- ↑ Pall, Martin L. (2000), "Elevated Peroxynitrite as the Cause of Chronic Fatigue Syndrome: Other Inducers and Mechanisms of Symptom Generation", Journal of Chronic Fatigue Syndrome, 7 (4): 45-58, doi:10.1300/J092v07n04_05
- ↑ Pall, Martin (2000), "Cobalamin Used in Chronic Fatigue Syndrome Therapy Is a Nitric Oxide Scavenger", Journal of Chronic Fatigue Syndrome, 8 (2): 39-44, doi:10.1300/J092v08n02_04
- ↑ Pall, ML. (2001). Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. Medical Hypotheses, 57 (2):139-45. PMID:11461161
- ↑ Pall ML, Satterlee JD. (2001). Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome, and posttraumatic stress disorder. Annals of the New York Academy of Science, 933.323-9. PMID:12000033
- ↑ Martin L. Pall. (2002). Levels of Nitric Oxide Synthase Product Citrulline Are Elevated in Sera of Chronic Fatigue Syndrome Patients. Journal of Chronic Fatigue Syndrome, Vol. 10, Iss. 2, pp. 37-41.
- ↑ Pall, ML. (2002). Chronic fatigue syndrome/myalgic encephalitis. British Journal of General Practice, 52 (482):762. PMID:12236283
- ↑ Smirnova IV, Pall ML. (2003). Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients. Molecular and Cellular Biochemistry, 248 (1-2):93-5. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12870659
- ↑ Pall ML. (2005). Nitric oxide and the etiology of chronic fatigue syndrome: giving credit where credit is due. Medical Hypotheses, 65 (3):631-3. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/15936892.
- ↑ Pall, ML. (2008). Post-radiation syndrome as a NO/ONOO- cycle, chronic fatigue syndrome-like disease. Medical Hypotheses, 71 (4):537-41. doi:10.1016/j.mehy.2008.05.023. Epub 2008 Jul 29. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18667279
- ↑ Carruthers, Bruce M.; van de Sande, Marjorie I.; De Meirleir, Kenny L.; Klimas, Nancy G.; Broderick, Gordon; Mitchell, Terry; Staines, Donald; Powles, A. C. Peter; Speight, Nigel; Vallings, Rosamund; Bateman, Lucinda; Baumgarten-Austrheim, Barbara; Bell, David; Carlo-Stella, Nicoletta; Chia, John; Darragh, Austin; Jo, Daehyun; Lewis, Donald; Light, Alan; Marshall-Gradisnik, Sonya; Mena, Ismael; Mikovits, Judy; Miwa, Kunihisa; Murovska, Modra; Pall, Martin; Stevens, Staci (August 22, 2011). "Myalgic encephalomyelitis: International Consensus Criteria". Journal of Internal Medicine. 270 (4): 327–338. doi:10.1111/j.1365-2796.2011.02428.x. ISSN 0954-6820. PMC 3427890. PMID 21777306.
- ↑ Höck, Anna Dorothea; Pall, Martin L. (2011), "Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue?", Medical Hypotheses, 76 (2): 208-13, doi:10.1016/j.mehy.2010.09.032, PMID 20980105