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Mast cell activation syndrome
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==Signs and Symptoms== In MCAS, the body's [[mast cell]]s are being created in normal number, but are over responsive to dietary or environmental triggers. Both of these situations might lead an individual to have excess [[histamine]] in circulation. Excess histamine can cause severe inflammation and a wide variety of symptoms. Almost any organ system in the body can be affected by MCAS.<ref name="Akin2017">{{Cite journal | last = Akin | first = Cem | date = Aug 2017 | title = Mast Cell Activation Syndromes|url=https://pubmed.ncbi.nlm.nih.gov/28780942/|journal=The Journal of Allergy and Clinical Immunology|volume=140|issue=2 | pages = 349β355|via=}}</ref> Because a variety of symptoms can be present, MCAS is commonly misdiagnosed. A confounding element in diagnosing MCAS is that signs and symptoms occur in almost all areas of the body. The symptoms might wax and wane. Most patients experience [[fatigue]], [[fever]]s, and sensitivity to individualized environmental "triggers." Other commonly identified signs and symptoms are as follows: *[[Hot flushes|Hot flashes]], [[cardiac arrhythmia|irregular heartbeat]], high or low blood pressure ([[hypotension]] and/or [[hypertension]]) *[[vertigo]], [[dizziness]], [[Memory problems|forgetfulness]], [[depression]] or [[anxiety]], [[headache]]s, [[insomnia]], restlessness *[[hives]] or other visible [[skin rash]]es *[[arthritis]], [[Myalgia|muscle pain]], bone pain, [[osteoporosis]]/osteopenia *[[anaphylaxis]] (a severe allergic reaction) *[[Malabsorption]] and [[Gastrointestinal system|gastrointestinal]] distress leading to low [[iron]] and low [[Vitamin D]] and low [[Cobalamin|Vitamin B12]]<ref name="Molderings2011" />
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