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Mast cell activation syndrome
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==Myalgic Encephalomyelitis and Chronic Fatigue Syndrome == Most MCAS pstients have [[fatigue]], and approximately half have [[cognitive dysfunction]], and many symptoms of ME/CFS are also found; this may result in other a [[misdiagnosis of myalgic encephalomyelitis and chronic fatigue syndrome|misdiagnosis of chronic fatigue syndrome]] or be the result of having both illnesses.<ref name="Afrin2016" /> The rate of [[post-exertional malaise]], which is now considered the hallmark of ME/CFS, is unknown in MCAS patients. Research on the relationship between mast cells and ME is in its infancy. One study found that individuals diagnosed with [[Moderate myalgic encephalomyelitis or chronic fatigue syndrome|moderate]] to [[severe and very severe ME|severe ME]] have been noted to have higher amounts of dysfunctional mast cells in circulation.<ref name="Nguyen, et al, 2017">{{Cite journal | last = Nguyen | first1 = T. | authorlink1 = | last2 = Johnston | first2 = S. | authorlink2 = | last3 = Chacko | first3 = A. | authorlink3 = | last4 = Gibson | first4 = D. | authorlink4= | last5 = Cepon | first5 = J. | authorlink5 = | last6 = Smith | first6 = D. | authorlink6 = | last7 = Staines | first7 = D. | authorlink7 = Donald Staines | last8 =Marshall-Gradisnik | first8 = S. | authorlink8 = Sonya Marshall-Gradisnik | url = https://pubmed.ncbi.nlm.nih.gov/27362406/ | title = Novel characterisation of mast cell phenotypes from peripheral blood mononuclear cells in chronic fatigue syndrome/myalgic encephalomyelitis patients | journal = Asian Pac J Allergy Immunol | volume = 35 | issue = 2 | page = 75-81 | date = 2017| doi = 10.12932/AP0771}}</ref> At a two-day physician summit in Salt Lake City, Utah in March 2018, physicians discussed the relationship between [[chronic fatigue syndrome]] and mast cell activation syndrome.<ref name="medscapeCFS">{{Cite web|url=https://www.medscape.com/viewarticle/893858 | title = Mast Cell Activation May Underlie 'Chronic Fatigue Syndrome' | date = Mar 13, 2018 | website = Medscape | last = Tucker | first = Miriam IE.|access-date=2018-09-25}}</ref> *[[Charles Lapp]]: "I see a lot of this. I think it's one of the many overlap syndromes that we've been missing for years." *[[Susan Levine]]: "I suspect 50% to 60% of ME/CFS patients have it. It's a very new concept."...In Levine's experience, MCAS often manifests in patients being unable to tolerate certain foods or medications. "If we can reduce the mast cell problem, we can facilitate taking other drugs to treat ME/CFS," she said. However, she also cautioned, "It's going to be a subset, not all ME/CFS patients."
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