NTRK: Difference between revisions

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'''Neurotrophic Receptor Tyrosine Kinase''' or '''NTRK''' is a superfamily of receptor tyrosine kinases<ref name="Thiriet2011">https://books.google.co.uk/books?id=MF_kmIWZRrMC&lpg=PA654&dq=NTRK%20Neurotrophic%20receptor%20tyrosine%20kinase&pg=PA654#v=onepage&q=NTRK%20Neurotrophic%20receptor%20tyrosine%20kinase&f=true</ref > these are protein-encoding genes that may be linked to [[myalgic encephalomyelitis]]/<wbr>[[chronic fatigue syndrome]].<ref name="AlmenarPerez2020" />
'''Neurotrophic Receptor Tyrosine Kinase''' or '''NTRK''' is a superfamily of receptor tyrosine kinases<ref name="Thiriet2011">{{Cite book|title=Signaling at the Cell Surface in the Circulatory and Ventilatory Systems|pages=648|isbn=978-1-4614-1991-4|edition=|volume=|language=en|title-link=|url=https://books.google.co.uk/books?id=MF_kmIWZRrMC&lpg=PA654&dq=NTRK%20Neurotrophic%20receptor%20tyrosine%20kinase&pg=PA654#v=onepage&q=NTRK%20Neurotrophic%20receptor%20tyrosine%20kinase&f=true|access-date=|date=2011-12-14|publisher=Springer Science & Business Media|last=Thiriet|first=Marc|author-link=|last2=|first2=|author-link2=|last3=|first3=|author-link3=|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|author-link7=|last8=|first8=|author-link8=|last9=|first9=|author-link9=|veditors=|others=|doi=|oclc=|quote=|archive-url=|archive-date=|location=}}</ref> these are protein-encoding genes that may be linked to [[myalgic encephalomyelitis]]/<wbr>[[chronic fatigue syndrome]].<ref name="AlmenarPerez2020" />


===NTRK1===
===NTRK1===
Neurotrophic Tyrosine Kinase Receptor 1 is one of the NTKR family of protein-encoding genes.<ref name="genecards">https://www.genecards.org/cgi-bin/carddisp.pl?gene=NTRK1</ref >  
Neurotrophic Tyrosine Kinase Receptor 1 is one of the NTKR family of protein-encoding genes.<ref name="genecards">{{Cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=NTRK1|title=NTRK1 Gene {{!}} NTRK1 Protein {{!}} NTRK1 Antibody|last=GeneCards|first=|authorlink=|last2=|first2=|authorlink2=|date=|website=www.genecards.org|archive-url=|archive-date=|dead-url=|access-date=2020-02-12}}</ref>  


==ME/CFS ==
==ME/CFS ==
Almenar-Pérez et al (2020) found that NTRK appeared to be affected in patients with severe ME/CFS, which could relate to "symptoms such as [[cognitive dysfunction |cognitive disability]] and sensorial dysfunctions (altered [[pain sensitivity]])<sup>44</sup>".<ref name="AlmenarPerez2020" /> In this small study of patients with [[severe and very severe ME|severe ME]], '''NTRK1''' levels were found to be significantly higher in the severely ill patients compared to healthy controls.<ref name="AlmenarPerez2020" />
Almenar-Pérez et al (2020) found that NTRK appeared to be affected in patients with severe ME/CFS, which could relate to "symptoms such as [[cognitive dysfunction |cognitive disability]] and sensorial dysfunctions (altered [[Allodynia|pain sensitivity]])<sup>44</sup>".<ref name="AlmenarPerez2020" /> In this small study of patients with [[severe and very severe ME|severe ME]], '''NTRK1''' levels were found to be significantly higher in the severely ill patients compared to healthy controls.<ref name="AlmenarPerez2020" />


== Notable studies ==
== Notable studies ==
* Feb 7, 2020 - Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/<wbr>Chronic Fatigue Syndrome.<ref name="AlmenarPerez2020">https://doi.org/10.1038/s41598-020-58506-5</ref>
* Feb 7, 2020 - Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/<wbr>Chronic Fatigue Syndrome.<ref name="AlmenarPerez2020">{{Cite journal|last=Almenar-Pérez|first=Eloy|author-link=|last2=Sarría|first2=Leonor|author-link2=|last3=Nathanson|first3=Lubov|author-link3=Lubov Nathanson|last4=Oltra|first4=Elisa|author-link4=Elisa Oltra|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=2020-02-07|title=Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://www.nature.com/articles/s41598-020-58506-5|journal=Scientific Reports|language=en|volume=10|issue=1|pages=1–15|doi=10.1038/s41598-020-58506-5|issn=2045-2322|pmc=|pmid=|access-date=Feb 12, 2020|quote=|via=}}</ref>


==See also ==
==See also ==
* [[Tyrosine]]
* [[Diagnostic biomarker]]
* [[Diagnostic biomarker]]


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[[Category:Biochemistry and cell biology]]
[[Category:Biochemistry and cell biology]]
[[Category:Enzymes]]
[[Category:Enzymes]]
<references />

Revision as of 15:46, February 12, 2020

Neurotrophic Receptor Tyrosine Kinase or NTRK is a superfamily of receptor tyrosine kinases[1] these are protein-encoding genes that may be linked to myalgic encephalomyelitis/chronic fatigue syndrome.[2]

NTRK1[edit | edit source]

Neurotrophic Tyrosine Kinase Receptor 1 is one of the NTKR family of protein-encoding genes.[3]

ME/CFS[edit | edit source]

Almenar-Pérez et al (2020) found that NTRK appeared to be affected in patients with severe ME/CFS, which could relate to "symptoms such as cognitive disability and sensorial dysfunctions (altered pain sensitivity)44".[2] In this small study of patients with severe ME, NTRK1 levels were found to be significantly higher in the severely ill patients compared to healthy controls.[2]

Notable studies[edit | edit source]

  • Feb 7, 2020 - Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.[2]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. Thiriet, Marc (December 14, 2011). Signaling at the Cell Surface in the Circulatory and Ventilatory Systems. Springer Science & Business Media. p. 648. ISBN 978-1-4614-1991-4.
  2. 2.0 2.1 2.2 2.3 Almenar-Pérez, Eloy; Sarría, Leonor; Nathanson, Lubov; Oltra, Elisa (February 7, 2020). "Assessing diagnostic value of microRNAs from peripheral blood mononuclear cells and extracellular vesicles in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". Scientific Reports. 10 (1): 1–15. doi:10.1038/s41598-020-58506-5. ISSN 2045-2322. Retrieved February 12, 2020.
  3. GeneCards. "NTRK1 Gene | NTRK1 Protein | NTRK1 Antibody". www.genecards.org. Retrieved February 12, 2020. Cite has empty unknown parameter: |dead-url= (help)