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Natural killer cell
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==Notable studies== *1987, Phenotypic and functional deficiency of natural killer cells in patients with [[chronic fatigue syndrome]] [https://www.ncbi.nlm.nih.gov/pubmed/2824604 (Abstract)] *2003, Predictive immunophenotypes: Disease-related profile in chronic fatigue syndrome [http://onlinelibrary.wiley.com/doi/10.1002/cyto.b.10034/full (Full Text)] *2015, Low NK Cell Activity in Chronic Fatigue Syndrome (CFS) and Relationship to Symptom Severity [https://www.omicsonline.org/open-access/low-nk-cell-activity-in-chronic-fatigue-syndrome-cfs-and-relationship-to-symptom-severity-2155-9899-1000348.php?aid=59415 (Full Text)] *May 2015 - [http://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-015-0101-4 Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)], ''BMC Immunology'', 2015 16:35 *May 2015 - [https://journals.sagepub.com/doi/full/10.4137/III.S25147 Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients]<ref>{{Cite journal | last = Marshall-Gradisnik | first = Sonya M. | authorlink = Sonya Marshall-Gradisnik | last2 = Smith | first2 = Peter | authorlink2 = Peter Smith | last3 = Brenu | first3 = Ekua W. | authorlink3 = Ekua Brenu | last4 = Nilius | first4=Bernd | authorlink4 = Bernd Nilius | last5 = Ramos | first5 = Sandra B. | authorlink5 = Sandra Ramos | last6 = Staines | first6 = Donald R. | date = 2015-01-01 | title = Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients|url=https://doi.org/10.4137/III.S25147|journal=[[Immunology and Immunogenetics Insights]]|language=en|volume=7|issue=|pages=III.S25147|doi=10.4137/III.S25147|issn=1178-6345|quote=|via=}}</ref> (small study - 115 people with ME/CFS) *May 2015 - [http://www.la-press.com/examination-of-single-nucleotide-polymorphisms-snps-in-transient-recep-article-a4824 Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients], ''Immunology and Immunogenetics Insights'', 2015:7 1-6. (small study - 115 people with ME/CFS) *Dec 2015, [http://onlinelibrary.wiley.com/doi/10.1111/sji.12388/abstract Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis]<ref name="NKcells-2015">{{Cite journal | last = Huth | first = T.K. | authorlink = Teilah Huth | last2 = Brenu | first2 = E.W. | authorlink2 = Ekua Brenu | last3 = Ramos | first3 = S. | authorlink3 = Sandra Ramos | last4 = Nguyen | first4=T. | authorlink4 = Thao Nguyen | last5 = Broadley | first5 = S. | authorlink5 = Simon Broadley | last6 = Staines | first6 = D. | authorlink6 = Donald Staines | last7 = Marshall‐Gradisnik | first7 = S. | authorlink7 = Sonya Marshall-Gradisnik | date = 2016 | title=Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/sji.12388|journal=[[Scandinavian Journal of Immunology]]|language=en|volume=83|issue=1 | pages = 44–51|doi=10.1111/sji.12388|issn=1365-3083|quote=|via=}}</ref> (Abstract) *Jan 2016, [https://journals.sagepub.com/doi/full/10.4137/III.S37042 Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients]<ref name="Genotype-2016">{{Cite journal | last = Marshall-Gradisnik | first = S.M. | authorlink = Sonya Marshall-Gradisnik | last2 = Chacko | first2 = A. | authorlink2 = A Chacko | last3 = Johnston | first3 = S. | authorlink3 = Samantha Johnston | last4 = Smith | first4 = P. | authorlink4 = Peter Smith | last5 = Nilius | first5 = B. | authorlink5 = B Nilius | last6 = Staines | first6 = D.R. | authorlink6 = Donald Staines | date = 2016-01-01 | title = Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients|url=https://doi.org/10.4137/III.S37042|journal=Immunology and Immunogenetics Insights|language=en|volume=8|issue=|pages=III.S37042|doi=10.4137/III.S37042|issn=1178-6345|quote=|via=}}</ref> [https://journals.sagepub.com/doi/full/10.4137/III.S37042 (Full text)] *Apr 2016, [http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0859-z ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients]<ref name=":0">{{Cite journal | last = Huth | first = Teilah Kathryn | authorlink = Teilah Huth | last2 = Staines | first2 = Donald | authorlink2 = Donald Staines | last3 = Marshall-Gradisnik | first3 = Sonya | authorlink3 = Sonya Marshall-Gradisnik | authorlink4 = | authorlink5 = | date = 2016-04-21 | title = ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients|url=https://doi.org/10.1186/s12967-016-0859-z|journal=[[Journal of Translational Medicine]]|volume=14|issue=1 | pages = 97|doi=10.1186/s12967-016-0859-z|issn=1479-5876|pmc=4839077|pmid=27098723|quote=|via=}}</ref> (Full text) *May 2016, [https://biolres.biomedcentral.com/articles/10.1186/s40659-016-0087-2 Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients]<ref name="TRPM3-2016">{{Cite journal | last = Nguyen | first = T. | authorlink = Thao Nguyen | last2 = Staines | first2 = D. | authorlink2 = Donald Staines | last3 = Nilius | first3 = B. | authorlink3 = B Nilius | last4 = Smith | first4 = P. | authorlink4 = Peter Smith | last5 = Marshall-Gradisnik | first5 = S. | authorlink5 = Sonya Marshall-Gradisnik | date = 2016-05-31 | title = Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients|url=https://doi.org/10.1186/s40659-016-0087-2|journal=[[Biological Research (journal)|Biological Research]]|volume=49|issue=1|pages=27|doi=10.1186/s40659-016-0087-2|issn=0717-6287|pmc=4888729|pmid=27245705|quote=|via=}}</ref> (Full text) *2016, Dysregulation of Protein Kinase Gene Expression in NK Cells from [[ME/CFS|Chronic Fatigue Syndrome/Myalgic Encephalomyelitis]] Patients<ref name="Chacko, 2016" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003121/ (Full Text)] *2016, Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome [https://www.dovepress.com/natural-killer-cells-and-single-nucleotide-polymorphisms-of-specific-i-peer-reviewed-fulltext-article-TACG (Full Text)] *2016, Killer Cell Immunoglobulin-like Receptor [[Genotype]] and [[Haplotype]] Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients [http://journals.sagepub.com/doi/full/10.4137/GRSB.S39861 (Full Text)] *2016, [[MicroRNA|MicroRNAs]] [[hsa-miR-99b]], [[hsa-miR-330]], [[hsa-miR-126]] and [[hsa-miR-30c]]: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME)<ref name="PettyD2016" /> *2018, Association of [[T cell|T]] and NK cell phenotype with the diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref name="Rivas, 2018" /> [https://www.frontiersin.org/articles/10.3389/fimmu.2018.01028/abstract (Abstract)] *2018, [[Rituximab]] impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation<ref name="Eaton, 2018" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870391/ (Full Text)] *Aug 2018, Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients<ref>{{Cite journal | last = Cabanas | first = Hélène | authorlink = Hélène | last2 = Muraki | first2 = Katsuhiko | authorlink2 = Katsuhiko Muraki | last3 = Eaton | first3 = Natalie | authorlink3 = Natalie Eaton-Fitch | last4 = Balinas | first4=Cassandra | authorlink4 = Cassandra Balinas | last5 = Staines | first5 = Donald | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = Sonya | authorlink6 = Sonya Marshall-Gradisnik | date = 2018-08-14 | title = Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092868/|journal=Molecular Medicine|volume=24|issue=|pages=|doi=10.1186/s10020-018-0046-1|issn=1076-1551|pmc=6092868|pmid=30134818|quote=|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092868/#__ffn_sectitle (Full text)] *May 2019, Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients<ref>{{Cite journal | last = Cabanas | first = H. | authorlink = Hélène Cabanas | last2 = Muraki | first2 = K. | authorlink2 = Katsuhiko Muraki | last3 = Balinas | first3 = C. | authorlink3 = Cassandra Balinas | last4 = Eaton-Fitch | first4 = N. | authorlink4 = Natalie Eaton-Fitch | last5 = Staines | first5 = D. | authorlink5 = Donald Staines | last6 = Marshall-Gradisnik | first6 = S. | authorlink6 = Sonya Marshall-Gradisnik | date = 2019-04-23 | title = Validation of impaired Transient Receptor Potential Melastatin 3 ion channel activity in natural killer cells from Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis patients|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480905/|journal=[[Molecular Medicine]]|volume=25|issue=|pages=|doi=10.1186/s10020-019-0083-4|issn=1076-1551|pmc=6480905|pmid=31014226|quote=|via=}}</ref> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480905/ (Full text)]
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