Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Neural strain
(section)
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
=== Tension === In animal models, stretching or tension of nerves results in substantially reduced blood flow.<ref name=":0" /><ref name=":1">{{Cite journal | last = Clark | first = William L. | last2 = Trumble | first2 = Thomas E. | last3 = Swiontkowski | first3 = Mark F. | last4 = Tencer | first4 = Allan F. | date = 1992-07-01 | title = Nerve tension and blood flow in a rat model of immediate and delayed repairs|url=http://www.sciencedirect.com/science/article/pii/036350239290316H|journal=The Journal of Hand Surgery|volume=17|issue=4 | pages = 677–687|doi=10.1016/0363-5023(92)90316-H|issn=0363-5023}}</ref><ref name=":3">{{Cite journal | last = Clark | first = William L. | last2 = Trumble | first2 = Thomas E. | last3 = Swiontkowski | first3 = Mark F. | last4 = Tencer | first4 = Allan F. | date = 1992-07-01 | title = Nerve tension and blood flow in a rat model of immediate and delayed repairs|url=http://www.sciencedirect.com/science/article/pii/036350239290316H|journal=The Journal of Hand Surgery|volume=17|issue=4 | pages = 677–687|doi=10.1016/0363-5023(92)90316-H|issn=0363-5023}}</ref><ref name=":4">{{Cite journal | last = Driscoll | first = Peter J. | last2 = Glasby | first2 = Michael A. | last3 = Lawson | first3 = Graham M. | date = 2002 | title = An in vivo study of peripheral nerves in continuity: biomechanical and physiological responses to elongation | url =https://onlinelibrary.wiley.com/doi/abs/10.1016/S0736-0266%2801%2900104-8|journal=Journal of Orthopaedic Research|language=en|volume=20|issue=2|pages=370–375|doi=10.1016/S0736-0266(01)00104-8|issn=1554-527X}}</ref><ref name=":6">{{Cite journal | last = Tanoue | first = M. | last2 = Yamaga | first2 = M. | last3 = Ide | first3 = J. | last4 = Takagi | first4 = K. | date = Jun 1996 | title = Acute stretching of peripheral nerves inhibits retrograde axonal transport|url=https://www.ncbi.nlm.nih.gov/pubmed/8771477|journal=Journal of Hand Surgery (Edinburgh, Scotland)|volume=21|issue=3|pages=358–363|issn=0266-7681|pmid=8771477}}</ref><ref name=":7">{{Cite journal | last = Ogata | first = K. | last2 = Naito | first2 = M. | date = Feb 1986 | title = Blood flow of peripheral nerve effects of dissection, stretching and compression | url =https://www.ncbi.nlm.nih.gov/pubmed/3958526|journal=Journal of Hand Surgery (Edinburgh, Scotland)|volume=11|issue=1|pages=10–14|issn=0266-7681|pmid=3958526}}</ref><ref name=":8">{{Cite journal | last= Jou | first = I.M. | last2 = Lai | first2 = K.A. | last3 = Shen | first3 = C.L. | last4 = Yamano | first4 = Y. | date = Jan 2000 | title = Changes in conduction, blood flow, histology, and neurological status following acute nerve-stretch injury induced by femoral lengthening | url =https://www.ncbi.nlm.nih.gov/pubmed/10716291|journal=Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society|volume=18|issue=1|pages=149–155|doi=10.1002/jor.1100180121|issn=0736-0266|pmid=10716291}}</ref><ref>{{Cite journal | last = Ogata | first = Kosuke | last2 = Naito | first2 = Masatoshi | date = 1986-02-01 | title = Blood flow of peripheral nerve effects of dissection stretching and compression | url =http://www.sciencedirect.com/science/article/pii/0266768186900033|journal=The Journal of Hand Surgery: British & European Volume|volume=11|issue=1|pages=10–14|doi=10.1016/0266-7681(86)90003-3|issn=0266-7681}}</ref> Tension impairs nerve regeneration.<ref>{{Cite journal | last = Sunderland | first = Ian R.P. | last2 = Brenner | first2 = Michael J. | last3 = Singham | first3 = Janakie | last4 = Rickman | first4 = Susan R. | last5 = Hunter | first5 = Daniel A. | last6 = Mackinnon | first6 = Susan E. | date = Oct 2004 | title = Effect of Tension on Nerve Regeneration in Rat Sciatic Nerve Transection Model|url=https://journals.lww.com/annalsplasticsurgery/Abstract/2004/10000/Effect_of_Tension_on_Nerve_Regeneration_in_Rat.16.aspx|journal=Annals of Plastic Surgery|language=en-US|volume=53|issue=4|pages=382|doi=10.1097/01.sap.0000125502.63302.47|issn=0148-7043}}</ref> ===== Tethered cord syndrome ===== {{Main article|page_name=Tethered cord syndrome}} [[Tethered cord syndrome]], a condition where tissue attachments limit the movement of the spinal cord within the spinal column, is associated with impaired glucose metabolism in spinal cord tissue,<ref name=":2">{{Cite journal | last = Colohan | first = Austin R.T. | last2 = Zouros | first2 = Alexander | last3 = Siddiqi | first3 = Javed | last4 = Yamada | first4 = Shoko M. | last5 = Yamada | first5 = Brian S. | last6 = Pezeshkpour | first6 = Gholam | last7 = Won | first7 = Daniel J. | last8 = Yamada | first8 = Shokei | date = 2007-08-01 | title = Pathophysiology of tethered cord syndrome and similar complex disorders|url=https://thejns.org/view/journals/neurosurg-focus/23/2/foc-07_08_e6.xml|journal=Neurosurgical Focus|language=en-US|volume=23|issue=2|pages=1–10|doi=10.3171/FOC-07/08/E6|issn=1092-0684}}</ref> changes in the reduction/oxidation ratio of [[cytochrome oxidase]].<ref>{{Cite journal | last = Yamada | first = Shoko M. | last2 = Won | first2 = Daniel J. | last3 = Yamada | first3 = Shokei | date = 2004-02-01 | title = Pathophysiology of tethered cord syndrome: correlation with symptomatology|url=https://thejns.org/view/journals/neurosurg-focus/16/2/foc.2004.16.2.7.xml|journal=Neurosurgical Focus|language=en-US|volume=16|issue=2|pages=1–5|doi=10.3171/foc.2004.16.2.7|issn=1092-0684}}</ref> and reduced ATP production.<ref name=":10">{{Cite journal | last = Sullivan | first = Stephen | last2 = Park | first2 = Paul | last3 = Stetler | first3 = William R. | date = 2010-07-01 | title = Pathophysiology of adult tethered cord syndrome: review of the literature|url=https://thejns.org/view/journals/neurosurg-focus/29/1/2010.3.focus1080.xml|journal=Neurosurgical Focus|language=en-US|volume=29|issue=1| pages = E2|doi=10.3171/2010.3.FOCUS1080|issn=1092-0684}}</ref> People with tethered cord syndrome have reduced blood flow to the spinal cord.<ref name=":22">{{Cite journal | last = Colohan | first = Austin R.T. | last2 = Zouros | first2 = Alexander | last3 = Siddiqi | first3 = Javed | last4 = Yamada | first4 = Shoko M. | last5 = Yamada | first5 = Brian S. | last6 = Pezeshkpour | first6 = Gholam | last7 = Won | first7 = Daniel J. | last8 = Yamada | first8 = Shokei | date = 2007-08-01 | title = Pathophysiology of tethered cord syndrome and similar complex disorders|url=https://thejns.org/view/journals/neurosurg-focus/23/2/foc-07_08_e6.xml|journal=Neurosurgical Focus|language=en-US|volume=23|issue=2|pages=1–10|doi=10.3171/FOC-07/08/E6|issn=1092-0684}}</ref> A study of energy cost of walking in adolescents with tethered cord, as measured by oxygen uptake (VO2), found that “energy cost per metre during walking at preferred speed and physical strain were higher than in peers without disability.”<ref>{{Cite journal | last = Bruinings | first = A.L. | last2 = Berg‐Emons | first2 = H. J. G. Van Den | last3 = Buffart | first3 = L.M. | last4 = Heijden‐Maessen | first4 = H. C.M. Van Der | last5 = Roebroeck | first5 = M.E. | last6 = Stam | first6 = H.J. | date = 2007 | title=Energy cost and physical strain of daily activities in adolescents and young adults with myelomeningocele|url=https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1469-8749.2007.00672.x|journal=Developmental Medicine & Child Neurology|language=en|volume=49|issue=9 | pages = 672–677|doi=10.1111/j.1469-8749.2007.00672.x|issn=1469-8749}}</ref> “Traction on the caudal cord results in decreased blood flow causing metabolic derangements that culminate in motor, sensory, and urinary neurological deficits. The untethering operation restores blood flow and reverses the clinical picture in most symptomatic cases.”<ref>{{Cite journal | last = Rekate | first = Harold L. | last2 = Theodore | first2 = Nicholas | last3 = Kalani | first3 = M. Yashar | last4 = Filippidis | first4 = Aristotelis S. | date = 2010-07-01 | title = Spinal cord traction, vascular compromise, hypoxia, and metabolic derangements in the pathophysiology of tethered cord syndrome|url=https://thejns.org/view/journals/neurosurg-focus/29/1/2010.3.focus1085.xml|journal=Neurosurgical Focus|language=en-US|volume=29|issue=1| pages = E9|doi=10.3171/2010.3.FOCUS1085|issn=1092-0684}}</ref> In a study of five children undergoing surgery for tethered cord syndrome group, spinal cord blood flow prior to untethering was a mean of 12.6 ml/min per 100 g of tissue. It increased in all cases after release to a mean of 29.4 ml/min per 100 g of tissue.<ref>{{Cite journal | last = Danto | first = Joseph | last2 = Greenberg | first2 = Burt M. | last3 = Rosenthal | first3 = Alan D. | last4 = Schneider | first4 = Steven J. | date = 1993-02-01 | title = A Preliminary Report on the Use of Laser-Doppler Flowmetry during Tethered Spinal Cord Release|url=https://academic.oup.com/neurosurgery/article/32/2/214/2804055|journal=Neurosurgery|language=en|volume=32|issue=2|pages=214–218|doi=10.1227/00006123-199302000-00010|issn=0148-396X}}</ref>
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs