Pentadecapeptide BPC 157: Difference between revisions

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'''Pentadecapeptide BPC 157''', a fragment of gastric juice peptide BPC,<ref>{{Cite journal|last=Sikiric|first=Predrag|last2=Seiwerth|first2=Sven|last3=Grabarevic|first3=Zeljko|last4=Petek|first4=Marijan|last5=Rucman|first5=Rudolf|last6=Turkovic|first6=Branko|last7=Rotkvic|first7=Ivo|last8=Jagic|first8=Vjekoslav|last9=Duvnjak|first9=Marko|date=1994-01-01|title=The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides|url=http://www.sciencedirect.com/science/article/pii/0024320594007969|journal=Life Sciences|volume=54|issue=5|pages=PL63–PL68|doi=10.1016/0024-3205(94)00796-9|issn=0024-3205}}</ref> is an experimental compound used in research for its potential applications in wound healing, [[collagen]] repair and [[angiogenesis]].<ref>{{Cite web|url=https://www.ingentaconnect.com/content/ben/cpd/2014/00000020/00000007/art00009|title=BPC 157 and Blood Vessels|last=Seiwerth|first=Sven|last2=Brcic|first2=Luka|date=2014|website=www.ingentaconnect.com|language=en|access-date=2019-06-24|last3=Batelja Vuletic|first3=Lovorka|last4=Kolenc|first4=Danijela|last5=Aralica|first5=Gorana|last6=Misic|first6=Marija|last7=Zenko|first7=Anita|last8=Drmic|first8=Domagoj|last9=Rucman|first9=Rudolf}}</ref>
'''Pentadecapeptide BPC 157''', a fragment of gastric juice peptide BPC,<ref>{{Cite journal|last=Sikiric|first=Predrag|last2=Seiwerth|first2=Sven|last3=Grabarevic|first3=Zeljko|last4=Petek|first4=Marijan|last5=Rucman|first5=Rudolf|last6=Turkovic|first6=Branko|last7=Rotkvic|first7=Ivo|last8=Jagic|first8=Vjekoslav|last9=Duvnjak|first9=Marko|date=1994-01-01|title=The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides|url=http://www.sciencedirect.com/science/article/pii/0024320594007969|journal=Life Sciences|volume=54|issue=5|pages=PL63–PL68|doi=10.1016/0024-3205(94)00796-9|issn=0024-3205}}</ref> is derived from human [[Gastric acid|stomach acid]]. It is an experimental compound used in research for its potential applications in wound healing, [[collagen]] repair and [[angiogenesis]].<ref>{{Cite web|url=https://www.ingentaconnect.com/content/ben/cpd/2014/00000020/00000007/art00009|title=BPC 157 and Blood Vessels|last=Seiwerth|first=Sven|last2=Brcic|first2=Luka|date=2014|website=www.ingentaconnect.com|language=en|access-date=2019-06-24|last3=Batelja Vuletic|first3=Lovorka|last4=Kolenc|first4=Danijela|last5=Aralica|first5=Gorana|last6=Misic|first6=Marija|last7=Zenko|first7=Anita|last8=Drmic|first8=Domagoj|last9=Rucman|first9=Rudolf}}</ref>


BPC 157 improved wound healing in rats with muscle crush injury and contusions, and quadricep transection,<ref>{{Cite journal|last=Staresinic|first=Mario|last2=Petrovic|first2=Igor|last3=Novinscak|first3=Tomislav|last4=Jukic|first4=Ivana|last5=Pevec|first5=Damira|last6=Suknaic|first6=Slaven|last7=Kokic|first7=Neven|last8=Batelja|first8=Lovorka|last9=Brcic|first9=Luka|date=2006|title=Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.20089|journal=Journal of Orthopaedic Research|language=en|volume=24|issue=5|pages=1109–1117|doi=10.1002/jor.20089|issn=1554-527X}}</ref><ref name=":0">{{Cite journal|last=Staresinic|first=Mario|last2=Petrovic|first2=Igor|last3=Novinscak|first3=Tomislav|last4=Jukic|first4=Ivana|last5=Pevec|first5=Damira|last6=Suknaic|first6=Slaven|last7=Kokic|first7=Neven|last8=Batelja|first8=Lovorka|last9=Brcic|first9=Luka|date=2006|title=Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.20089|journal=Journal of Orthopaedic Research|language=en|volume=24|issue=5|pages=1109–1117|doi=10.1002/jor.20089|issn=1554-527X}}</ref> even in the presence of corticosteroids (which impair wound healing).<ref name=":0" /> It has also demonstrated efficacy in experimental ulcer models<ref>{{Cite journal|last=Sikiric|first=Predrag|last2=Seiwerth|first2=Sven|last3=Grabarevic|first3=Zeljko|last4=Petek|first4=Marijan|last5=Rucman|first5=Rudolf|last6=Turkovic|first6=Branko|last7=Rotkvic|first7=Ivo|last8=Jagic|first8=Vjekoslav|last9=Duvnjak|first9=Marko|date=1994-01-01|title=The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides|url=http://www.sciencedirect.com/science/article/pii/0024320594007969|journal=Life Sciences|volume=54|issue=5|pages=PL63–PL68|doi=10.1016/0024-3205(94)00796-9|issn=0024-3205}}</ref> and models of traumatic nerve injury.<ref>{{Cite journal|last=Gjurasin|first=Miroslav|last2=Miklic|first2=Pavle|last3=Zupancic|first3=Bozidar|last4=Perovic|first4=Darko|last5=Zarkovic|first5=Kamelija|last6=Brcic|first6=Luka|last7=Kolenc|first7=Danijela|last8=Radic|first8=Bozo|last9=Seiwerth|first9=Sven|date=2010-02-25|title=Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury|url=http://www.sciencedirect.com/science/article/pii/S0167011509002274|journal=Regulatory Peptides|volume=160|issue=1|pages=33–41|doi=10.1016/j.regpep.2009.11.005|issn=0167-0115}}</ref>
BPC 157 improved wound healing in rats with muscle crush injury and contusions, and quadricep transection,<ref>{{Cite journal|last=Staresinic|first=Mario|last2=Petrovic|first2=Igor|last3=Novinscak|first3=Tomislav|last4=Jukic|first4=Ivana|last5=Pevec|first5=Damira|last6=Suknaic|first6=Slaven|last7=Kokic|first7=Neven|last8=Batelja|first8=Lovorka|last9=Brcic|first9=Luka|date=2006|title=Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.20089|journal=Journal of Orthopaedic Research|language=en|volume=24|issue=5|pages=1109–1117|doi=10.1002/jor.20089|issn=1554-527X}}</ref><ref name=":0">{{Cite journal|last=Staresinic|first=Mario|last2=Petrovic|first2=Igor|last3=Novinscak|first3=Tomislav|last4=Jukic|first4=Ivana|last5=Pevec|first5=Damira|last6=Suknaic|first6=Slaven|last7=Kokic|first7=Neven|last8=Batelja|first8=Lovorka|last9=Brcic|first9=Luka|date=2006|title=Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.20089|journal=Journal of Orthopaedic Research|language=en|volume=24|issue=5|pages=1109–1117|doi=10.1002/jor.20089|issn=1554-527X}}</ref> even in the presence of corticosteroids (which impair wound healing).<ref name=":0" /> It has also demonstrated efficacy in experimental ulcer models<ref>{{Cite journal|last=Sikiric|first=Predrag|last2=Seiwerth|first2=Sven|last3=Grabarevic|first3=Zeljko|last4=Petek|first4=Marijan|last5=Rucman|first5=Rudolf|last6=Turkovic|first6=Branko|last7=Rotkvic|first7=Ivo|last8=Jagic|first8=Vjekoslav|last9=Duvnjak|first9=Marko|date=1994-01-01|title=The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides|url=http://www.sciencedirect.com/science/article/pii/0024320594007969|journal=Life Sciences|volume=54|issue=5|pages=PL63–PL68|doi=10.1016/0024-3205(94)00796-9|issn=0024-3205}}</ref> and models of traumatic nerve injury.<ref>{{Cite journal|last=Gjurasin|first=Miroslav|last2=Miklic|first2=Pavle|last3=Zupancic|first3=Bozidar|last4=Perovic|first4=Darko|last5=Zarkovic|first5=Kamelija|last6=Brcic|first6=Luka|last7=Kolenc|first7=Danijela|last8=Radic|first8=Bozo|last9=Seiwerth|first9=Sven|date=2010-02-25|title=Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury|url=http://www.sciencedirect.com/science/article/pii/S0167011509002274|journal=Regulatory Peptides|volume=160|issue=1|pages=33–41|doi=10.1016/j.regpep.2009.11.005|issn=0167-0115}}</ref>
It has been shown to increase expression of many types of growth factors<ref>{{Cite web|url=https://www.ingentaconnect.com/content/ben/cpd/2018/00000024/00000018/art00009|title=BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing|last=Seiwerth|first=Sven|last2=Rucman|first2=Rudolf|date=2018|website=www.ingentaconnect.com|language=en|access-date=2019-09-11|last3=Turkovic|first3=Branko|last4=Sever|first4=Marko|last5=Klicek|first5=Robert|last6=Radic|first6=Bozo|last7=Drmic|first7=Domagoj|last8=Stupnisek|first8=Mirjana|last9=Misic|first9=Marija}}</ref><ref name=":1">{{Cite journal|last=Pang|first=Jong-Hwei Su|last2=Hsu|first2=Ya-Hui|last3=Tsai|first3=Wen-Chung|last4=Chang|first4=Chung-Hsun|date=2014/11|title=Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts|url=https://www.mdpi.com/1420-3049/19/11/19066|journal=Molecules|language=en|volume=19|issue=11|pages=19066–19077|doi=10.3390/molecules191119066}}</ref><ref name=":2">{{Cite journal|last=Hsieh|first=Ming-Jer|last2=Liu|first2=Hsien-Ta|last3=Wang|first3=Chao-Nin|last4=Huang|first4=Hsiu-Yun|last5=Lin|first5=Yuling|last6=Ko|first6=Yu-Shien|last7=Wang|first7=Jong-Shyan|last8=Chang|first8=Vincent Hung-Shu|last9=Pang|first9=Jong-Hwei S.|date=2017-03-01|title=Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation|url=https://doi.org/10.1007/s00109-016-1488-y|journal=Journal of Molecular Medicine|language=en|volume=95|issue=3|pages=323–333|doi=10.1007/s00109-016-1488-y|issn=1432-1440}}</ref> including [[growth hormone receptor]]<ref name=":1" /> and [[vascular endothelial growth factor]]<ref name=":2" /> (VEGF) expression on [[Fibroblast|fibroblasts]].


== References ==
== References ==

Revision as of 13:52, September 11, 2019

Pentadecapeptide BPC 157, a fragment of gastric juice peptide BPC,[1] is derived from human stomach acid. It is an experimental compound used in research for its potential applications in wound healing, collagen repair and angiogenesis.[2]

BPC 157 improved wound healing in rats with muscle crush injury and contusions, and quadricep transection,[3][4] even in the presence of corticosteroids (which impair wound healing).[4] It has also demonstrated efficacy in experimental ulcer models[5] and models of traumatic nerve injury.[6]

It has been shown to increase expression of many types of growth factors[7][8][9] including growth hormone receptor[8] and vascular endothelial growth factor[9] (VEGF) expression on fibroblasts.

References

  1. ↑ Sikiric, Predrag; Seiwerth, Sven; Grabarevic, Zeljko; Petek, Marijan; Rucman, Rudolf; Turkovic, Branko; Rotkvic, Ivo; Jagic, Vjekoslav; Duvnjak, Marko (January 1, 1994). "The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides". Life Sciences. 54 (5): PL63–PL68. doi:10.1016/0024-3205(94)00796-9. ISSN 0024-3205.
  2. ↑ Seiwerth, Sven; Brcic, Luka; Batelja Vuletic, Lovorka; Kolenc, Danijela; Aralica, Gorana; Misic, Marija; Zenko, Anita; Drmic, Domagoj; Rucman, Rudolf (2014). "BPC 157 and Blood Vessels". www.ingentaconnect.com. Retrieved June 24, 2019.
  3. ↑ Staresinic, Mario; Petrovic, Igor; Novinscak, Tomislav; Jukic, Ivana; Pevec, Damira; Suknaic, Slaven; Kokic, Neven; Batelja, Lovorka; Brcic, Luka (2006). "Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157". Journal of Orthopaedic Research. 24 (5): 1109–1117. doi:10.1002/jor.20089. ISSN 1554-527X.
  4. ↑ 4.0 4.1 Staresinic, Mario; Petrovic, Igor; Novinscak, Tomislav; Jukic, Ivana; Pevec, Damira; Suknaic, Slaven; Kokic, Neven; Batelja, Lovorka; Brcic, Luka (2006). "Effective therapy of transected quadriceps muscle in rat: Gastric pentadecapeptide BPC 157". Journal of Orthopaedic Research. 24 (5): 1109–1117. doi:10.1002/jor.20089. ISSN 1554-527X.
  5. ↑ Sikiric, Predrag; Seiwerth, Sven; Grabarevic, Zeljko; Petek, Marijan; Rucman, Rudolf; Turkovic, Branko; Rotkvic, Ivo; Jagic, Vjekoslav; Duvnjak, Marko (January 1, 1994). "The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides". Life Sciences. 54 (5): PL63–PL68. doi:10.1016/0024-3205(94)00796-9. ISSN 0024-3205.
  6. ↑ Gjurasin, Miroslav; Miklic, Pavle; Zupancic, Bozidar; Perovic, Darko; Zarkovic, Kamelija; Brcic, Luka; Kolenc, Danijela; Radic, Bozo; Seiwerth, Sven (February 25, 2010). "Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury". Regulatory Peptides. 160 (1): 33–41. doi:10.1016/j.regpep.2009.11.005. ISSN 0167-0115.
  7. ↑ Seiwerth, Sven; Rucman, Rudolf; Turkovic, Branko; Sever, Marko; Klicek, Robert; Radic, Bozo; Drmic, Domagoj; Stupnisek, Mirjana; Misic, Marija (2018). "BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing". www.ingentaconnect.com. Retrieved September 11, 2019.
  8. ↑ 8.0 8.1 Pang, Jong-Hwei Su; Hsu, Ya-Hui; Tsai, Wen-Chung; Chang, Chung-Hsun (2014/11). "Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts". Molecules. 19 (11): 19066–19077. doi:10.3390/molecules191119066. Check date values in: |date= (help)
  9. ↑ 9.0 9.1 Hsieh, Ming-Jer; Liu, Hsien-Ta; Wang, Chao-Nin; Huang, Hsiu-Yun; Lin, Yuling; Ko, Yu-Shien; Wang, Jong-Shyan; Chang, Vincent Hung-Shu; Pang, Jong-Hwei S. (March 1, 2017). "Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation". Journal of Molecular Medicine. 95 (3): 323–333. doi:10.1007/s00109-016-1488-y. ISSN 1432-1440.
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