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Persistent fatigue induced by interferon-alpha: a novel, inflammation-based, proxy model of chronic fatigue syndrome
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{{stub}} This study looked at inflammatory markers in people with persistent [[fatigue]] that began after treating Hepatitis C with [[interferon alpha]] therapy, and persisted for at least 6 months after.<ref>{{Cite journal | last = Russell | first = Alice | authorlink = Alice Russell | last2 = Hepgul | first2 = Nilay | authorlink2 = Nilay Hepgul | last3 = Nikkheslat | first3 = Naghmeh | authorlink3 = Naghmeh Nikkheslat | authorlink4 = Alessandra Borsini | author-link5 = Zuzanna Zajkowska | authorlink6 = Natalie Moll | authorlink7 = Daniel Forton | authorlink8 = Kosh Agarwal | authorlink9 = Trudie Chalder | last4 = Borsini | first4 = Alessandra | last5 = Zajkowska | first5 = Zuzanna | last6 = Moll | first6 = Natalie | last7 = Forton | first7 = Daniel | last8 = Agarwal | first8 = Kosh | last9 = Chalder | first9 = Trudie | last10 = Mondelli | first10 = Valeria | last11 = Hotopf | first11 = Matthew | authorlink11 = Matthew Hotopf | last12 = Anthony | first12 = Cleare | authorlink12 = Anthony Cleare | last13 = Murphy | first13 = Gabrielle | author-link13 = Gabrielle Murphy | last14 = Wong | first14 = Terry | author-link14 = Terry Wong | last15 = Foster | first15 = Graham | author-link15 = Graham Foster | last16 = Schütze | first16 = Gregor A. | authorlink16=Gregor Schütze | last17 = Schwarz | first17 = Markus J. | authorlink17 = Markus Schwarz | last18 = Harrison | first18 = Neil | author-link18 = Neil Harrison | last19 = Zunszain | first19 = Patricia | author-link19 = Patricia Zunszain | last20 = Pariante | first20 = Carmine | author-link20 = Carmine Pariante | date = 2018 | title = Persistent fatigue induced by interferon-alpha: a novel, inflammation-based, proxy model of chronic fatigue syndrome|url=https://www.sciencedirect.com/science/article/pii/S0306453018301963|journal=Psychoneuroendocrinology|language=en|volume=|issue=|pages=|doi=10.1016/j.psyneuen.2018.11.032|issn=0306-4530|access-date=2018-12-18|quote=|via= | authorlink10 = Valeria Mondelli}}</ref> The initial grant described the persistent [[fatigue]] and [[flu-like symptoms]] occurring after treatment of Hepatitis C with Interferon alpha therapy as being remarkably similar to Chronic Fatigue Syndrome.<ref>{{Cite web|url=https://mrc.ukri.org/documents/pdf/cfsme-current-projects/| title = CFS/ME Current Projects | last = Medical Research Council | first = | authorlink = Medical Research Council | date = |website=mrc.ukri.org|archive-url=|archive-date=|url-status=|access-date=2018-12-19}}</ref> This study is due to be published in 2019, a corrected proof was made available online in December 2018, and a press release, science briefing and interviews with the media were held in December 2018, ahead of publication.<ref>{{Cite web|url=http://www.sciencemediacentre.org/the-biology-of-chronic-fatigue/| title = The biology of chronic fatigue {{!}} Science Media Centre | last = Pariante | first = Carmine | authorlink=Carmine Pariante | last2 = Russell | first2 = Alice | authorlink2 = Alice Russell | date = 2018-12-14 | website = [[Science Media Centre]]|language=en|archive-url=|archive-date=|url-status=|access-date=2018-12-19}}</ref> ==Funding== * [[Medical Research Council]] grant name: Persistent Fatigue Induced by Interferon-alpha: A New Immunological Model for Chronic Fatigue Syndrome (MR/J002739/1), awarded to [[Carmine Pariante]], the 20th author. * "Additional support" from the [[National Institute for Health Research]] [[Mental Health Biomedical Research Centre in Mental Health]] at South London and Maudsley NHS Foundation Trust and King’s College London, both of which also part supported [[Trudie Chalder]]. * Principle investigator [[Alice Russell]] also received support from the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London at King's College Hospital NHS Foundation Trust. == Conflicts of interest == * This study included a long list of conflicts of interest, almost entirely related to prior hepatitis funding, drug companies that produce treatments for hepatitis and prior funding for research apparently unrelated to ME/CFS. * [[Carmine Pariante]], who the Medical Research Council grant was awarded to, also disclosed prior funding on depression and inflammation in the conflicts of interest. ==Results== ==Criticism from scientists== * Dec 17, 2018, [http://steamtraen.blogspot.com/2018/12/have-scientists-found-explanation-for.html Have scientists found explanation for the onset of ME/CFS?]<ref>{{Cite web|url=http://steamtraen.blogspot.com/2018/12/have-scientists-found-explanation-for.html| title = Nick Brown's blog: Have scientists found an explanation for the onset of ME/CFS? | last = Brown | first = Nick | date = 2018-12-17 | website = Nick Brown's blog|access-date=2018-12-19}}</ref> - Nick Brown * Dec 18, 2018, [http://www.virology.ws/2018/12/19/trial-by-error-the-new-interferon-cfs-study/ Trial By Error: The New Interferon “CFS” Study]<ref>{{Cite web|url=http://www.virology.ws/2018/12/19/trial-by-error-the-new-interferon-cfs-study/| title = Trial By Error: The New Interferon “CFS” Study | last = Tuller | first = David | authorlink = David Tuller | date = 2018-12-19 | website = [[Virology blog]]|language=en-US|archive-url=|archive-date=|url-status=|access-date=2018-12-20}}</ref> - [[David Tuller]] == Responses and criticism from charities == * Charity [[Action for ME]] welcomed the study, but criticized the choice of diagnostic criteria, stating it did not include [[post-exertional malaise]], the "hallmark" symptom of ME/CFS, which could lead to patients with other non-fatiguing conditions being included<ref>{{Cite web|url=https://twitter.com/actionforme/status/1074612761118826496| title = NEW RESEARCH: Prof Carmine Pariante has announced the results of #research which states that an overactive immune system may explain the cause of chronic fatigue syndrome. #CFS | last = M.E | first = Action for | date = 2018-12-17 | website = @actionforme|language=en|access-date=2018-12-19}}</ref> * [[The MEAction Network|#MEAction]] Missing Millions urged caution == Criticism from citizen scientists == * "This lower KYN/TRP ratio in #CFS is somewhat in opposition to a study of somatization which observed higher levels of the KYN/TRP ratio. This points to a different biological underpinning of primarily psychiatric syndromes, such as depression & somatization, as opposed to CFS."<ref>{{Cite web|url=https://mobile.twitter.com/TomKindlon/status/1074517907961466881| title = Tweet status 1074517907961466881 | last = Kindlon | first = Tom | authorlink=Tom Kindlon | date = |website=Twitter|language=en|archive-url=|archive-date=|url-status=|access-date=2018-12-19}}</ref> - [[Tom Kindlon]] * [https://www.s4me.info/threads/persistent-fatigue-induced-by-interferon-alpha-a-novel-inflammation-based-proxy-model-of-chronic-fatigue-syndrome-2018-pariante-et-al.7050/ Science4ME forum] ==Investigators== [[Alice Russell]], [[Nilay Hepgul]], [[Naghmeh Nikkheslat]], [[Alessandra Borsini]], [[Zuzanna Zajkowska]], [[Natalie Moll]], [[Daniel Forton]], [[Kosh Agarwal]], [[Trudie Chalder]], [[Valeria Mondelli]], [[Matthew Hotopf]], [[Anthony Cleare]], [[Gabrielle Murphy]], [[Graham Foster]], [[Terry Wong]], [[Gregor Schütze|Gregor A. Schütze]], [[Markus Schwarz|Markus J. Schwarz]], [[Neil Harrison]], [[Patricia Zunszain|Patricia A. Zunszain]], [[Carmine Pariante|Carmine A. Pariante]] ==Media coverage == This study has had media coverage, and a briefing for journalists was held at the [[Science Media Centre]], [[UK]]. * 2018, Could overactive immune system trigger Chronic Fatigue Syndrome?<ref>{{Cite news | url=https://www.bbc.com/news/health-46570494| title = Could overactive immune system trigger ME? | last = Ives | first = Laurel | date = 2018-12-17|work=BBC News|access-date=2018-12-19|language=en-GB}}</ref> * 2018, First look at sufferers before they fall ill suggests overactive immune system can put them 'on trajectory' to years of exhaustion<ref>{{Cite web|url=https://www.independent.co.uk/news/health/me-chronic-fatigue-syndrome-myalgic-encephalopathy-immune-system-virus-infection-diagnosis-gp-kings-a8684111.html| title = Hope for ME patients as immune system study challenges stigma that chronic fatigue is 'all in the mind' | last = Matthews-King | first = Alex | authorlink = | date = 2018-12-17 | website = The Independent|language=en|archive-url=|archive-date=|url-status=|access-date=2018-12-19}}</ref> * 2018, Study finds chronic fatigue clues in overactive immune response<ref>{{Cite news | url=https://uk.reuters.com/article/us-health-chronicfatigue-idUKKBN1OG00O| title = Study finds chronic fatigue clues in overactive immune response | last = Kelland | first = Kate | date = 2018-12-17|work=Reuters|access-date=2018-12-19|archive-url=|archive-date=|url-status=|language=en|quote=}}</ref> * 2018, Chronic fatigue syndrome 'could be triggered by overactive immune system'<ref>{{Cite news | url=http://www.theguardian.com/society/2018/dec/17/chronic-fatigue-syndrome-could-be-triggered-by-overactive-immune-system| title = Chronic fatigue syndrome 'could be triggered by overactive immune system' | last = Davis | first = Nicola | date = 2018-12-17|work=The Guardian|access-date=2018-12-19|language=en-GB|issn=0261-3077}}</ref> ==Talks and interviews== ==See also== * [[Interferon]] * [[Interferon alpha]] * [[Oxford criteria]] * [[Biopsychosocial model]] * [[Medical Research Council]] ==Learn more== * [https://mrc.ukri.org/documents/pdf/cfsme-current-projects/ CFS/ME Ongoing Projects] - grant MR/J002739/1 - Medical Research Council ==References == {{Reflist}} [[Category:Notable studies]]
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