Post-polio syndrome: Difference between revisions

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== Incidence and prevalence ==
== Incidence and prevalence ==
The exact incidence and prevalence of postpolio syndrome (PPS) is unknown and statistics vary. Medscape reports the incidence in previous acute polio patients ranges from approximately 22-68%.<ref name=":1" /> The [[National Institutes of Health|NIH]] estimates that the condition affects 25 to 40 percent of polio survivors.<ref name=":0" /> In 1992, a study of former poliomyelitis patients from Allegheny County, Pennsylvania estimates 28.5% of all paralytic polio cases develop PPS.<ref>{{Cite journal|last=Ramlow|first=J.|last2=Alexander|first2=M.|last3=LaPorte|first3=R.|last4=Kaufmann|first4=C.|last5=Kuller|first5=L.|date=1992-10-01|title=Epidemiology of the Post-Polio Syndrome|url=https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/136.7.769|journal=American Journal of Epidemiology|language=en|volume=136|issue=7|pages=769–786|doi=10.1093/aje/136.7.769|issn=0002-9262}}</ref> Suggestions have been made that 100% of polio survivors, if tracked for a long period, can develop some symptoms of PPS.<ref name=":1" />
The exact incidence and prevalence of postpolio syndrome (PPS) is unknown and statistics vary. Medscape reports the incidence in previous acute polio patients ranges from approximately 22-68%.<ref name=":1" /> The [[National Institutes of Health|NIH]] estimates that the condition affects 25 to 40 percent of polio survivors.<ref name=":0" /> In 1992, a study of former poliomyelitis patients from Allegheny County, Pennsylvania estimates 28.5% of all paralytic polio cases develop PPS.<ref>{{Cite journal|last=Ramlow|first=J.|last2=Alexander|first2=M.|last3=LaPorte|first3=R.|last4=Kaufmann|first4=C.|last5=Kuller|first5=L.|date=1992-10-01|title=Epidemiology of the Post-Polio Syndrome|url=https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/136.7.769|journal=American Journal of Epidemiology|language=en|volume=136|issue=7|pages=769–786|doi=10.1093/aje/136.7.769|issn=0002-9262}}</ref> Suggestions have been made that 100% of polio survivors, if tracked for a long period, can develop some symptoms of PPS.<ref name=":1" />
== ME/CFS ==
A study in 2019, using the self-reporting questionnaires, DePaul Symptom Questionnaire 2 (DSQ-2) and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), found that participants with ME/CFS were more functionally impaired across symptoms than those with PPS.<ref name=":2" /> Additionally, the study found that the three domains that most commonly differentiated ME/CFS from PPS were neurocognitive, [[post-exertional malaise]], and neuroendocrine.<ref name=":2" />


==Research studies==
==Research studies==
* 2019, Differentiating post-polio syndrome from myalgic encephalomyelitis and chronic fatigue syndrome<ref>{{Cite journal|last=Klebek|first=Lauren|author-link=|last2=Sunnquist|first2=Madison|author-link2=Madison Sunnquist|last3=Jason|first3=Leonard A.|author-link3=Leonard Jason|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=2019-10-02|title=Differentiating post-polio syndrome from myalgic encephalomyelitis and chronic fatigue syndrome|url=https://www.tandfonline.com/doi/full/10.1080/21641846.2019.1687117|journal=Fatigue: Biomedicine, Health & Behavior|language=en|volume=7|issue=4|pages=196–206|doi=10.1080/21641846.2019.1687117|issn=2164-1846|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.tandfonline.com/doi/full/10.1080/21641846.2019.1687117 (Abstract)]
* 2019, Differentiating post-polio syndrome from myalgic encephalomyelitis and chronic fatigue syndrome<ref name=":2">{{Cite journal|last=Klebek|first=Lauren|author-link=|last2=Sunnquist|first2=Madison|author-link2=Madison Sunnquist|last3=Jason|first3=Leonard A.|author-link3=Leonard Jason|last4=|first4=|author-link4=|last5=|first5=|author-link5=|last6=|first6=|author-link6=|last7=|first7=|last8=|first8=|date=2019-10-02|title=Differentiating post-polio syndrome from myalgic encephalomyelitis and chronic fatigue syndrome|url=https://www.tandfonline.com/doi/full/10.1080/21641846.2019.1687117|journal=Fatigue: Biomedicine, Health & Behavior|language=en|volume=7|issue=4|pages=196–206|doi=10.1080/21641846.2019.1687117|issn=2164-1846|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [https://www.tandfonline.com/doi/full/10.1080/21641846.2019.1687117 (Abstract)]


==See also==
==See also==

Revision as of 21:28, January 16, 2020

Post-polio syndrome (PPS, or post-poliomyelitis syndrome or post-polio sequelae) is a condition that affects polio survivors years after their recovery from an initial acute attack of the poliomyelitis virus.[1] It is characterized by new and progressive muscular weakness, pain, and fatigue many years after the occurrence of acute paralytic polio.[2]

Signs and symptoms[edit | edit source]

These include the following:[2][3]

  • Fatigue (both general and muscular)
  • Muscle weakness
  • Muscle pain
  • Gait disturbance
  • Respiratory problems
  • Swallowing problems (dysphagia)
  • Autonomic dysfunction
  • Sleep apnea
  • Flat-back syndrome

Incidence and prevalence[edit | edit source]

The exact incidence and prevalence of postpolio syndrome (PPS) is unknown and statistics vary. Medscape reports the incidence in previous acute polio patients ranges from approximately 22-68%.[2] The NIH estimates that the condition affects 25 to 40 percent of polio survivors.[1] In 1992, a study of former poliomyelitis patients from Allegheny County, Pennsylvania estimates 28.5% of all paralytic polio cases develop PPS.[4] Suggestions have been made that 100% of polio survivors, if tracked for a long period, can develop some symptoms of PPS.[2]

ME/CFS[edit | edit source]

A study in 2019, using the self-reporting questionnaires, DePaul Symptom Questionnaire 2 (DSQ-2) and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), found that participants with ME/CFS were more functionally impaired across symptoms than those with PPS.[5] Additionally, the study found that the three domains that most commonly differentiated ME/CFS from PPS were neurocognitive, post-exertional malaise, and neuroendocrine.[5]

Research studies[edit | edit source]

  • 2019, Differentiating post-polio syndrome from myalgic encephalomyelitis and chronic fatigue syndrome[5] - (Abstract)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 "Post-Polio Syndrome Fact Sheet | National Institute of Neurological Disorders and Stroke". www.ninds.nih.gov. Retrieved January 16, 2020.
  2. 2.0 2.1 2.2 2.3 "Postpolio Syndrome: Practice Essentials, Pathophysiology, Epidemiology". November 14, 2019. Cite journal requires |journal= (help)
  3. "Post-Polio Syndrome Information Page | National Institute of Neurological Disorders and Stroke". www.ninds.nih.gov. Retrieved January 16, 2020.
  4. Ramlow, J.; Alexander, M.; LaPorte, R.; Kaufmann, C.; Kuller, L. (October 1, 1992). "Epidemiology of the Post-Polio Syndrome". American Journal of Epidemiology. 136 (7): 769–786. doi:10.1093/aje/136.7.769. ISSN 0002-9262.
  5. 5.0 5.1 5.2 Klebek, Lauren; Sunnquist, Madison; Jason, Leonard A. (October 2, 2019). "Differentiating post-polio syndrome from myalgic encephalomyelitis and chronic fatigue syndrome". Fatigue: Biomedicine, Health & Behavior. 7 (4): 196–206. doi:10.1080/21641846.2019.1687117. ISSN 2164-1846.