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Progesterone
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==Bio-Identical Progesterone and BHRT == Many functional medicine doctors have begun supplementing patients with imbalanced hormone levels with bio-identical hormone replacement therapy (BHRT). The term "bio-identical" distinguishes these hormone supplements from the more conventionally used synthetic hormones created by pharmaceutical companies, because unlike the latter, bio-identical hormone supplements are identical in molecular structure to the natural hormones our bodies create. Whereas hormone replacement therapy (HRT) is widely known and highly conventional among mainstream medicine, BHRT is most often only heard of in functional or integrative medicine. A practitioner who uses BHRT will likely measure your hormone levels via saliva or blood sample, and prescribe your hormones through a compounding pharmacy. Bio-identical progesterone is synthesized from the naturally occurring diosgenin in wild yams or from the stigmasterol found in soy beans and can be taken as a transdermal cream, pill, or vaginal gel.<ref>{{Cite web|url=https://www.health.harvard.edu/womens-health/what-are-bioidentical-hormones| title = What are bioidentical hormones? | last = | first = | website = Harvard Health Publishing|access-date=2019-08-08}}</ref><ref name="penn">{{Cite web|url=http://pennstatehershey.adam.com/content.aspx?productId=107&pid=33&gid=000280| title = Complementary and Alternative Medicine - Wild yam | website = Penn State Hershey Medical Center|access-date=2019-08-08}}</ref><ref>{{Cite bool|chapter=Chapter 17 - Soybean Oil Processing Byproducts and Their Utilization | date = 1995-01-01|url=https://www.sciencedirect.com/science/article/pii/B9780935315639500218|pages=297–313 | last = Woerfel | first = John B.|isbn=978-0-935315-63-9|language=en|publisher=AOCS Press | editor-last = Erickson | editor-first = David R. | title=Practical Handbook of Soybean Processing and Utilization}}</ref> Over-the-counter progesterone supplements exist, but are likely too weak to be effective, and therefore a prescription is needed. Although bio-identical progesterone is sometimes considered more "natural" than progestins because its molecular structure is identical to endogenous progesterone, both progestins and bio-identical progesterone are synthesized by humans. Many believe bio-identical progesterone to be safe, but more long-term research studies are needed to confirm this.
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