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Prognosis for myalgic encephalomyelitis and chronic fatigue syndrome
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=== Illness severity === Many studies have found that illness severity at baseline is associated poorer outcomes over time. Disagreement exists however on which measures of illness best predict a worse prognosis.Β While Pheley et al. (1999)<ref name="Pheley1999" /> found an association with [[fatigue]], Ray et al. (1997)<ref name="Ray1997" /> reported the broader concept of somatic symptoms to be associated with poor outcomes.Β In a [[Norway|Norwegian]] study that followed ME/CFS patients who got sick after [[mononucleosis]], [[arthralgia|joint pain]] was an important predictor of prognosis.<ref name="Nyland2014" /> {| class="wikitable" | colspan="2" |<small>Does illness severity impact prognosis?</small> |- |<small>Yes</small> |<small>No</small> |- |<small>Ray et al., 1997.<ref name="Ray1997" /> (somatic symptoms)</small> |<small>Anderson et al., 2004.<ref name="Andersen2004" /></small> |- |<small>Pheley et al., 1999.<ref name="Pheley1999" /> (fatigue)</small> | |- |<small>Van der Werf et al., 2002.<ref name=":19" /></small> | |- |<small>Jason et al., 2011.<ref name="Jason2011" /></small> | |- |<small>Nyland et al., 2014.<ref name="Nyland2014" /> (arthralgia)</small> | |- |<small>Ciccone et al., 2010.<ref name=":16" /></small> | |}
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