Quetiapine: Difference between revisions
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'''Quetiapine''', also known under the brand name '''Seroquel''', is an atypical [[antipsychotic]] drug which is sometimes used off-label at lower doses to treat [[insomnia]].<ref name="drugscom">https://www.drugs.com/seroquel.html</ref ><ref name="FibroQandA" /> | '''Quetiapine''', also known under the brand name '''Seroquel''', is an atypical [[antipsychotic]] drug which is sometimes used off-label at lower doses to treat [[insomnia]].<ref name="drugscom">https://www.drugs.com/seroquel.html</ref ><ref name="FibroQandA" /><ref name="Wilson2019" /> Quetiapine is also a [[dopamine]] [[serotonin]] antagonist.<ref name="Wilson2019">https://www.dx.org/10.1177/0269881119855343</ref >{{Rp|934}} | ||
Quetiapine may be used for Schizophrenia, Bipolar disorder (manic depression), or, when combined with an [[antidepressant]], to treat [[depression]].<ref name="drugscom" /> | Quetiapine may be used for Schizophrenia, Bipolar disorder (manic depression), or, when combined with an [[antidepressant]], to treat [[depression]].<ref name="drugscom" /> | ||
==ME/CFS and Fibromyalgia== | ==ME/CFS and Fibromyalgia== | ||
It is a sedating drug sometimes used for ''off-label'' for insomnia in patients with [[Fibromyalgia]].<ref name="FibroQandA"> https://books.google.co.uk/books?id=dA4kQulQ2ZMC&lpg=PP1&vq=quetiapine&pg=PT80#v=onepage&q=insomnia&f=false</ref>{{Rp|80}} | It is a sedating drug sometimes used for ''off-label'' for insomnia, including in patients with [[Fibromyalgia]].<ref name="FibroQandA">https://books.google.co.uk/books?id=dA4kQulQ2ZMC&lpg=PP1&vq=quetiapine&pg=PT80#v=onepage&q=insomnia&f=false</ref>{{Rp|80}} <ref name="Wilson2019" /> | ||
==Theory== | ==Theory== | ||
==Evidence== | ==Evidence== | ||
There are no clinical trials for the use of quetiapine in patients with chronic fatigue syndrome or fibromyalgia. There have been several small clinical trials of 25mg of quetiapine in patients with insomnia, with mixed results.<ref name="Wilson2019" /> | |||
The [[International Consensus Criteria]] primer advises against the use of quetiapine in overweight patients with [[myalgic encephalomyelitis]].<ref name="ICP2011primer">{{citation | The [[International Consensus Criteria]] primer advises against the use of quetiapine in overweight patients with [[myalgic encephalomyelitis]].<ref name="ICP2011primer">{{citation | ||
| last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers | | last1 = Carruthers | first1 = BM | authorlink1 = Bruce Carruthers | ||
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| url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf | | url = http://www.investinme.org/Documents/Guidelines/Myalgic%20Encephalomyelitis%20International%20Consensus%20Primer%20-2012-11-26.pdf | ||
}}</ref>{{Rp|13}} | }}</ref>{{Rp|13}} | ||
==Risks and safety== | |||
==Costs and availability== | ==Costs and availability== | ||
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==Learn more== | ==Learn more== | ||
*[https://www.bap.org.uk/pdfs/BAP_Guidelines-Sleep.pdf British Association for Psychopharmacology consensus statement on evldence-based treatment of insomnia, parasomnias and cicadian rhythm disorders: An update] | |||
* | |||
==References== | ==References== | ||
Revision as of 16:31, April 7, 2020
Quetiapine, also known under the brand name Seroquel, is an atypical antipsychotic drug which is sometimes used off-label at lower doses to treat insomnia.[1][2][3] Quetiapine is also a dopamine serotonin antagonist.[3]:934
Quetiapine may be used for Schizophrenia, Bipolar disorder (manic depression), or, when combined with an antidepressant, to treat depression.[1]
ME/CFS and Fibromyalgia[edit | edit source]
It is a sedating drug sometimes used for off-label for insomnia, including in patients with Fibromyalgia.[2]:80 [3]
Theory[edit | edit source]
Evidence[edit | edit source]
There are no clinical trials for the use of quetiapine in patients with chronic fatigue syndrome or fibromyalgia. There have been several small clinical trials of 25mg of quetiapine in patients with insomnia, with mixed results.[3]
The International Consensus Criteria primer advises against the use of quetiapine in overweight patients with myalgic encephalomyelitis.[4]:13
Risks and safety[edit | edit source]
Costs and availability[edit | edit source]
Notable studies[edit | edit source]
- 2012, The role of Antipsychotics in the Management of Fibromyalgia[5] - (Abstract)
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- ↑ 1.0 1.1 https://www.drugs.com/seroquel.html
- ↑ 2.0 2.1 https://books.google.co.uk/books?id=dA4kQulQ2ZMC&lpg=PP1&vq=quetiapine&pg=PT80#v=onepage&q=insomnia&f=false
- ↑ 3.0 3.1 3.2 3.3 https://www.dx.org/10.1177/0269881119855343
- ↑ Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6
- ↑ https://link.springer.com/article/10.2165/11597130-000000000-00000
