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RCCX Genetic Module Theory
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==CAPS as a marker of illness== In Meglathery's experience, people with classic psychiatric illnesses almost always have CAPS as a backdrop, with or without the PTSD wiring. She found that CAPS is invariably present in hypermobile psychiatric patients who develop chronic illness and is present in the vast majority of other people who develop chronic illness, leading her to believe that it is a reliable marker for vulnerability to chronic illness. She believes that CYP21A2 mutations are the genetic basis for the development of four of the five major psychiatric illnesses (anxiety disorders, mood disorders, ADD, autism). Schizophrenia, with its basis in C4 (situated next to CYP21A2), is responsible for the fifth. These psychiatric illnesses share similar genetic underpinnings, which Meglathery says supports the RCCX Theory.<ref name="APS-2013-FMPDSGL" /> Her theory also shows congruence with that of [[Robert Naviaux|Naviaux]]<ref name="Naviaux2016" /> in which he postulates a hibernation-like state in long-standing CFS. Meglathery believes the effect of 21-hydroxylase overwhelm, PTSD brain wiring, downstream effects from TNXB mutations, and C4 mutations trigger and maintain an adaptive shutdown response of the mitochondria. This stress-induced mitochondrial dysregulation has recently been discovered in patients with severe CFS/ME by [[Ron Davis]] PhD and [[Robert Naviaux]] MD PhD (initially described by Naviaux). The symptoms which occur after 21-hydroxylase is overwhelmed are the same, independent of the trigger. While some mutations affecting these genes have been characterized (some TNXB and CYP21A2 mutations), evidence suggests there are many more uncharacterized genes. Many involve lengthy insertions and are therefore very difficult to study. These genes would have highly variable clinical effects, depending on the nature of the mutation. CYP21A2 mutations are in upwards of 20% of the population and C4 mutations are also extremely common, according to Meglathery.
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