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Thiamine
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==Chronic fatigue syndrome== One very small study found decreased functional status of several [[B vitamin]]s including [[Vitamin B6|pyridoxine]], [[riboflavin]] and thiamine.<ref name="vitbcfs1999" /> To date, high-dose thiamine has not been studied formally in patients with ME/CFS. However, an informal retrospective survey on the use of 200 mg or more daily of thiamine among 55 individuals with ME/CFS, fibromylagia or [[Ehlers-Danlos Syndrome]]s was reported in Health Rising in 2021.<ref>{{Cite web|url=https://www.healthrising.org/blog/2021/06/02/fibromyalgia-chronic-fatigue-syndrome-benefit-high-dose-thiamine/ | title = Nearly 2/3rds of Survey Respondents Report Large Benefits from High-Dose Thiamine (B-1) | last =Lubell | first = Jeffrey | authorlink= | date = | website = Health Rising|archive-url=|archive-date=|url-status=|access-date=2021-08-22}}</ref> Among the 55 individuals responding to the survey -- 49 of whom reported having ME/CFS -- nearly two-thirds reported large benefits from high-dose thiamine, with another 5 percent reporting smaller benefits. The most commonly reported benefits were reductions in fatigue, post-exertional malaise and brain fog. While the incidence of side effects was generally low, and most people reporting [[mast cell activation syndrome]] (MCAS) reported benefitting from high-dose thiamine, a number of respondents reported that high-dose thiamine made their MCAS symptoms substantially worse, suggesting that caution be exercised by those with severe MCAS or active flares. Formal research is needed on the potential of high-dose thiamine to benefit people with ME/CFS.
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