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Umifenovir
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'''Umifenovir''' (trade name: Arbidol) is a broad-spectrum [[antiviral]] approved for use in [[China]] and [[Russia]] for the treatment of [[influenza]]. Preliminary studies have shown that umifenovir has activity against [[Coxsackie B]] viruses. Umifenovir was found to have antiviral activity against [[Coxsackievirus B5|Coxsackie virus B5]] (CVB5) in vitro and in vivo, having both a cytopathic effect as well as directly reducing [[intracellular]] [[RNA]]. Orally administered umifenovir reduced virus in the lungs and heart, as well as mortality in an animal model of acute infection.<ref>{{Cite journal | last =Zhong | first = Qiong | date = April 2009 | title = Antiviral activity of Arbidol against Coxsackie virus B5 in vitro and in vivo|url=https://link.springer.com/article/10.1007/s00705-009-0346-4|journal=Archives of Virology|volume=154|pages=|via=}}</ref> A separate study found antiviral activity against [[Coxsackie B3]],<ref>{{Cite journal|url=https://www.ncbi.nlm.nih.gov/pubmed/17497238 | title = Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo | last =Shi | first = L | date = 2007 | journal=Archives of Virology|volume=152|pages=1447-55|via=}}</ref> and a third study found umifenovir inhibited [[Coxsackie B4]] in part by reducing the expression of [[interleukin 10|IL-10]] (by preventing p38-MK2 complex from exiting the nucleus).<ref>{{Cite journal|url=https://www.ncbi.nlm.nih.gov/pubmed/28263801 | title = Umifenovir effectively inhibits IL-10 dependent persistent Coxsackie B4 virus infection | last =Zhang | first = S | date = May 2017|journal=Antiviral Research|volume=141|pages=165-173|via=}}</ref> == See also == * [[Coxsackie B]] == Learn more == == References == [[Category:Antivirals]] {{Reflist}} [[Category:Potential treatments]]
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