Umifenovir

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Umifenovir (trade name: Arbidol) is a broad-spectrum antiviral approved for use in China and Russia for the treatment of influenza.

Preliminary studies have shown that umifenovir has activity against Coxsackie B viruses. Umifenovir was found to have antiviral activity against Coxsackie virus B5 (CVB5) in vitro and in vivo, having both a cytopathic effect as well as directly reducing intracellular RNA. Orally administered umifenovir reduced virus in the lungs and heart, as well as mortality in an animal model of acute infection.[1] A separate study found antiviral activity against Coxsackie B3,[2] and a third study found umifenovir inhibited Coxsackie B4 in part by reducing the expression of IL-10 (by preventing p38-MK2 complex from exiting the nucleus).[3]

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References

  1. ↑ Zhong, Qiong (April 2009). "Antiviral activity of Arbidol against Coxsackie virus B5 in vitro and in vivo". Archives of Virology. 154.
  2. ↑ Shi, L (2007). "Antiviral activity of arbidol against influenza A virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo". Archives of Virology. 152: 1447–55.
  3. ↑ Zhang, S (May 2017). "Umifenovir effectively inhibits IL-10 dependent persistent Coxsackie B4 virus infection". Antiviral Research. 141: 165–173.
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