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Vitamin C
(section)
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=== Mast cell activation disorder === Numerous studies have found Vitamin C to be inversely correlated with histamine and that the administration of Vitamin C reduces blood [[histamine]] levels.<ref name="clemetson1980" /><ref name="johnston1992" /><ref>{{Cite journal | last= Johnston | first = CS | last2 = Solomon | first2 = RE | last3 = Corte | first3=C | date = Dec 1996 | title = Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults|url=https://www.ncbi.nlm.nih.gov/pubmed/8951736|journal=J Am Coll Nutr.|volume=15 | issue =6 | pages = 586-591| doi=10.1080/07315724.1996.10718634|via=}}</ref> It does this potentially through several mechanisms: by inhibiting mast cell production; by increasing [[diamine oxidase]] (an [[enzyme]] that breaks down histamine); by inhibiting mast cell degranulation and the release of histamine in the first place (i.e., as a mast cell stabilizer),<ref name="Mio1999">{{Cite journal | last =Mio | first = M | date = 1999 | title=Ultraviolet B (UVB) light-induced histamine release from rat peritoneal mast cells and its augmentation by certain phenothiazine compounds|url=https://www.sciencedirect.com/science/article/pii/S0162310998000538|journal=Immunopharmacology|volume=|pages=|via=}}</ref> and by inhibiting [[histidine decarboxylase]] (the enzyme that forms histamine).<ref name="PMC4903110">{{Cite journal|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903110/ | title = Pharmacological treatment options for mast cell activation disease | last =Molderings | first=Gerhard | date = 2016 | journal=Naunyn Schmiedebergs Arch Pharmacol|volume=|pages=|via=}}</ref> [[File:Nihms-754526-f0008.jpg|right|300x300px]]
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