Anonymous
Not logged in
Talk
Contributions
Create account
Log in
Search
Editing
Voltage gated potassium channel antibodies
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
Namespaces
Page
Discussion
More
More
Page actions
Read
Edit
Edit source
History
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
{{Stub}} {{Cleanup/Multiple issues|Reason=Layout / MOS, no references, spelling and grammar, check if this was pasted from elsewhere. | date = Oct 16, 2019}} '''Voltage gated potassium channel antibodies''' (VGKC) are an [[autoantibody]] of unknown significance to [[ME/CFS]]. Voltage gated potassium channel antibodies (VGKC) are type of autoantibody against [[potassium]] ion channels found on neuronal (nerve) cell membranes and responsible for nerve transmission and returning of neuron to resting potential. Essential for normal functioning of all organ systems Voltage-gated potassium channel (VGKC)-complex antibodies can be associated with a range of clinical presentations including limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. However, there are patients with positive levels in whom the significance is uncertain.<ref>{{Cite journal | last =Paterson | first = Ross W. | last2 = Zandi | first2 = Michael S. | last3 = Armstrong | first3 = Richard | last4 = Vincent | first4=Angela | last5 = Schott | first5 = Jonathan M. | date = 2014-06-01 | title = Clinical relevance of positive voltage-gated potassium channel (VGKC)-complex antibodies: experience from a tertiary referral centre|url=https://jnnp.bmj.com/content/85/6/625|journal=Journal of Neurology, Neurosurgery & Psychiatry|language=en|volume=85|issue=6|pages=625β630|doi=10.1136/jnnp-2013-305218|issn=0022-3050|pmid=23757422}}</ref> Already known syndromes from antibodies to voltage-gated potassium channels include neuromyotonia (NMT), limbic encephalitis (LE) and Morvan syndrome (MVS). There are distinct clinical features for NMT (cramps, stiffness, fasciculations, myokymia, hyperhidrosis; afterdischarges and continuous motor activity on electromyogram), LE (encephalopathy with seizures, deficient recent memory; hyponatremia, temporal lobe magnetic resonance imaging and electroencephalographic abnormalities) and MVS (NMT plus hyperhidrosis, dysautonomia, encephalopathy, severe insomnia, and sleep disorders). There may be associated [[myasthenia gravis]] or thymoma, and rarely lung cancer (small cell or adenocarcinoma.<ref>{{Cite journal | last =Merchut | first = Michael P. | author-link = | date = Nov 2010 | title = Management of voltage-gated potassium channel antibody disorders|url=https://www.ncbi.nlm.nih.gov/m/pubmed/20816272/|journal=Neurologic Clinics|volume=28|issue=4 | pages = 941β959|doi=10.1016/j.ncl.2010.03.024|issn=1557-9875|pmc=|pmid=20816272|access-date=|quote=|via=}}</ref> Detected at high levels in some sufferers of CFS but of unknown significance.{{citation needed}} ==See also == *[[Ion transportation]] *[[Potassium]] ==Learn more == ==References == {{Reflist}} [[Category: Autoantibodies]]
Summary:
Please make sure your edits are consistent with
MEpedia's guidelines
.
By saving changes, you agree to the
Terms of use
, and you irrevocably agree to release your contribution under the
CC BY-SA 3.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)
Templates used on this page:
Template:Ambox
(
edit
)
Template:Asbox
(
edit
)
Template:Category handler
(
edit
)
Template:Citation needed
(
edit
)
Template:Cite journal
(
edit
)
Template:Cleanup
(
edit
)
Template:Cleanup/Multiple issues
(
edit
)
Template:Cleanup reason text
(
edit
)
Template:Colon
(
edit
)
Template:DMC
(
edit
)
Template:DMCA
(
edit
)
Template:Dated maintenance category
(
edit
)
Template:Digits
(
edit
)
Template:FULLROOTPAGENAME
(
edit
)
Template:Fix
(
edit
)
Template:Fix/category
(
view source
) (protected)
Template:Full stop
(
edit
)
Template:Full stop character
(
edit
)
Template:GetFallback
(
edit
)
Template:Help improve text
(
edit
)
Template:LangSwitch
(
edit
)
Template:Last word
(
edit
)
Template:Main other
(
edit
)
Template:No fullstop
(
edit
)
Template:No fullstop/first
(
edit
)
Template:Ns has subpages
(
edit
)
Template:Reflist
(
edit
)
Template:Str endswith
(
edit
)
Template:Str len
(
edit
)
Template:Stub
(
view source
) (semi-protected)
Template:Stub text
(
edit
)
Template:Uselang
(
edit
)
Template:Year
(
edit
)
Module:Arguments
(
edit
)
Module:Asbox
(
edit
)
Module:Buffer
(
edit
)
Module:Category handler
(
edit
)
Module:Category handler/blacklist
(
edit
)
Module:Category handler/config
(
edit
)
Module:Category handler/data
(
edit
)
Module:Category handler/shared
(
edit
)
Module:Check for unknown parameters
(
edit
)
Module:Citation/CS1
(
edit
)
Module:Citation/CS1/COinS
(
edit
)
Module:Citation/CS1/Configuration
(
edit
)
Module:Citation/CS1/Date validation
(
edit
)
Module:Citation/CS1/Identifiers
(
edit
)
Module:Citation/CS1/Utilities
(
edit
)
Module:Citation/CS1/Whitelist
(
edit
)
Module:Message box/configuration
(
edit
)
Module:Message box by year
(
edit
)
Module:Namespace detect/config
(
edit
)
Module:Namespace detect/data
(
edit
)
Module:Navbar
(
edit
)
Module:No globals
(
edit
)
Module:Ns has subpages
(
edit
)
Module:String
(
edit
)
Module:Unsubst
(
edit
)
Module:Yesno
(
edit
)
This page is a member of 7 hidden categories:
Category:All articles needing cleanup from 2019
Category:All articles with unsourced statements
Category:All stub articles
Category:Articles needing cleanup for multiple issues from 2019
Category:Articles with unsourced statements from unknown year
Category:Cleanup tagged articles with a reason field from 2019
Category:Stub pages last edited in 2023
Navigation
Navigation
Skip to content
Main page
Browse
Become an editor
Random page
Popular pages
Abbreviations
Glossary
About MEpedia
Links for editors
Contents
Guidelines
Recent changes
Pages in need
Search
Help
Wiki tools
Wiki tools
Special pages
Page tools
Page tools
User page tools
More
What links here
Related changes
Page information
Page logs